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Analysis of melamine in milk powder by using a magnetic molecularly imprinted polymer based on carbon nanotubes with ultra high performance liquid chromatography and tandem mass spectrometry.
J Sep Sci. 2016 Oct; 39(19):3775-3781.JS

Abstract

A new magnetic molecularly imprinted polymer was coupled with ultra high performance liquid chromatography and tandem mass spectrometry for the selective determination of melamine in milk powder. The magnetic molecularly imprinted polymer has been prepared by using carbon nanotubes as the matrix, Fe3 O4 particles as the magnetic ingredient, melamine as the template molecule, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross-linker and polyvinylpyrrolidone as the dispersant. The polymer was characterized with scanning electron microscopy, Fourier transform infrared spectroscopy and a physical property measurement system. The isothermal adsorption, kinetics adsorption, and selectivity were studied to evaluate the rebinding properties of the magnetic molecularly imprinted polymer. Various parameters affecting the extraction efficiency such as the amount of polymer, extraction time, and eluting solution were evaluated. The limit of detection was 0.00075 mg/kg. The relative standard deviations of the intraday and interday precision are 0.4-2.7 and 2.3-5.1%, respectively. The proposed method was successfully applied to determine melamine in different milk powder samples from different provenances, and satisfactory recoveries of 89.0-95.6% were obtained. This method has great significance for quality control and is simple and suitable for the rapid determination of melamine in milk powder.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhao X
Department of Chemistry, College of Science, Northeast Forestry University, China.
Chen L
Department of Chemistry, College of Science, Northeast Forestry University, China. ligangchen2010@aliyun.com.

MeSH

AdsorptionAnimalsCattleChromatography, High Pressure LiquidFood ContaminationMagneticsMilkMolecular ImprintingNanotubes, CarbonPolymersSolid Phase ExtractionTandem Mass SpectrometryTriazines

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

27504791

Citation

Zhao, Xiaoyu, and Ligang Chen. "Analysis of Melamine in Milk Powder By Using a Magnetic Molecularly Imprinted Polymer Based On Carbon Nanotubes With Ultra High Performance Liquid Chromatography and Tandem Mass Spectrometry." Journal of Separation Science, vol. 39, no. 19, 2016, pp. 3775-3781.
Zhao X, Chen L. Analysis of melamine in milk powder by using a magnetic molecularly imprinted polymer based on carbon nanotubes with ultra high performance liquid chromatography and tandem mass spectrometry. J Sep Sci. 2016;39(19):3775-3781.
Zhao, X., & Chen, L. (2016). Analysis of melamine in milk powder by using a magnetic molecularly imprinted polymer based on carbon nanotubes with ultra high performance liquid chromatography and tandem mass spectrometry. Journal of Separation Science, 39(19), 3775-3781. https://doi.org/10.1002/jssc.201600625
Zhao X, Chen L. Analysis of Melamine in Milk Powder By Using a Magnetic Molecularly Imprinted Polymer Based On Carbon Nanotubes With Ultra High Performance Liquid Chromatography and Tandem Mass Spectrometry. J Sep Sci. 2016;39(19):3775-3781. PubMed PMID: 27504791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of melamine in milk powder by using a magnetic molecularly imprinted polymer based on carbon nanotubes with ultra high performance liquid chromatography and tandem mass spectrometry. AU - Zhao,Xiaoyu, AU - Chen,Ligang, Y1 - 2016/09/06/ PY - 2016/06/06/received PY - 2016/07/25/revised PY - 2016/07/27/accepted PY - 2016/8/10/pubmed PY - 2018/2/3/medline PY - 2016/8/10/entrez KW - Carbon nanotubes KW - Magnetic separation KW - Melamine KW - Milk powder KW - Molecularly imprinted polymers SP - 3775 EP - 3781 JF - Journal of separation science JO - J Sep Sci VL - 39 IS - 19 N2 - A new magnetic molecularly imprinted polymer was coupled with ultra high performance liquid chromatography and tandem mass spectrometry for the selective determination of melamine in milk powder. The magnetic molecularly imprinted polymer has been prepared by using carbon nanotubes as the matrix, Fe3 O4 particles as the magnetic ingredient, melamine as the template molecule, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross-linker and polyvinylpyrrolidone as the dispersant. The polymer was characterized with scanning electron microscopy, Fourier transform infrared spectroscopy and a physical property measurement system. The isothermal adsorption, kinetics adsorption, and selectivity were studied to evaluate the rebinding properties of the magnetic molecularly imprinted polymer. Various parameters affecting the extraction efficiency such as the amount of polymer, extraction time, and eluting solution were evaluated. The limit of detection was 0.00075 mg/kg. The relative standard deviations of the intraday and interday precision are 0.4-2.7 and 2.3-5.1%, respectively. The proposed method was successfully applied to determine melamine in different milk powder samples from different provenances, and satisfactory recoveries of 89.0-95.6% were obtained. This method has great significance for quality control and is simple and suitable for the rapid determination of melamine in milk powder. SN - 1615-9314 UR - https://www.unboundmedicine.com/medline/citation/27504791/Analysis_of_melamine_in_milk_powder_by_using_a_magnetic_molecularly_imprinted_polymer_based_on_carbon_nanotubes_with_ultra_high_performance_liquid_chromatography_and_tandem_mass_spectrometry_ DB - PRIME DP - Unbound Medicine ER -