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Novel H2S Releasing Nanofibrous Coating for In Vivo Dermal Wound Regeneration.
ACS Appl Mater Interfaces 2016; 8(41):27474-27481AA

Abstract

Hydrogen sulfide (H2S), together with nitric oxide and carbon monoxide, has been recognized as an important gasotransmitter. It plays an essential physiological role in regulating cyto-protective signal process, and H2S-based therapy is considered as the next generation of promising therapeutic strategies for many biomedical applications, such as the treatment of cardiovascular disease. Through electrospinning of polycaprolactone (PCL) containing JK1, a novel pH-controllable H2S donor, nanofibers with H2S releasing function, PCL-JK1, are fabricated. This fibrous scaffold showed a pH-dependent H2S releasing behavior, i.e., lower pH induced greater and faster H2S release. In addition, the H2S release of JK1 was prolonged by the fibrous matrix as shown by decreased releasing rates compared to JK1 in solutions. In addition, in vitro studies indicated that PCL-JK1 exhibited excellent cyto-compatibility, similar to PCL fibers. Finally, we investigated PCL-JK1 as a wound dressing toward a cutaneous wound model in vivo and found that PCL-JK1 could significantly enhance the wound repair and regeneration compared with the control PCL scaffold, likely due to the release of H2S, which results in a broad range of physiologically protective functions toward the wound.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China. Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States. 486 Gallimore Dairy Rd, Greensboro, North Carolin 27409, United States.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University , Wenzhou, Zhejiang 325035, China.Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27504858

Citation

Wu, Jiang, et al. "Novel H2S Releasing Nanofibrous Coating for in Vivo Dermal Wound Regeneration." ACS Applied Materials & Interfaces, vol. 8, no. 41, 2016, pp. 27474-27481.
Wu J, Li Y, He C, et al. Novel H2S Releasing Nanofibrous Coating for In Vivo Dermal Wound Regeneration. ACS Appl Mater Interfaces. 2016;8(41):27474-27481.
Wu, J., Li, Y., He, C., Kang, J., Ye, J., Xiao, Z., ... Wang, Q. (2016). Novel H2S Releasing Nanofibrous Coating for In Vivo Dermal Wound Regeneration. ACS Applied Materials & Interfaces, 8(41), pp. 27474-27481. doi:10.1021/acsami.6b06466.
Wu J, et al. Novel H2S Releasing Nanofibrous Coating for in Vivo Dermal Wound Regeneration. ACS Appl Mater Interfaces. 2016 Oct 19;8(41):27474-27481. PubMed PMID: 27504858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel H2S Releasing Nanofibrous Coating for In Vivo Dermal Wound Regeneration. AU - Wu,Jiang, AU - Li,Yi, AU - He,Chaochao, AU - Kang,Jianming, AU - Ye,Jingjing, AU - Xiao,Zecong, AU - Zhu,Jingjing, AU - Chen,Anqi, AU - Feng,Sheng, AU - Li,Xiaokun, AU - Xiao,Jian, AU - Xian,Ming, AU - Wang,Qian, Y1 - 2016/10/07/ PY - 2016/8/10/pubmed PY - 2016/8/10/medline PY - 2016/8/10/entrez KW - controlled release KW - electrospinning KW - fibrous materials KW - hydrogen sulfide KW - polycaprolactone KW - wound healing SP - 27474 EP - 27481 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 8 IS - 41 N2 - Hydrogen sulfide (H2S), together with nitric oxide and carbon monoxide, has been recognized as an important gasotransmitter. It plays an essential physiological role in regulating cyto-protective signal process, and H2S-based therapy is considered as the next generation of promising therapeutic strategies for many biomedical applications, such as the treatment of cardiovascular disease. Through electrospinning of polycaprolactone (PCL) containing JK1, a novel pH-controllable H2S donor, nanofibers with H2S releasing function, PCL-JK1, are fabricated. This fibrous scaffold showed a pH-dependent H2S releasing behavior, i.e., lower pH induced greater and faster H2S release. In addition, the H2S release of JK1 was prolonged by the fibrous matrix as shown by decreased releasing rates compared to JK1 in solutions. In addition, in vitro studies indicated that PCL-JK1 exhibited excellent cyto-compatibility, similar to PCL fibers. Finally, we investigated PCL-JK1 as a wound dressing toward a cutaneous wound model in vivo and found that PCL-JK1 could significantly enhance the wound repair and regeneration compared with the control PCL scaffold, likely due to the release of H2S, which results in a broad range of physiologically protective functions toward the wound. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/27504858/Novel_H2S_Releasing_Nanofibrous_Coating_for_In_Vivo_Dermal_Wound_Regeneration_ L2 - https://dx.doi.org/10.1021/acsami.6b06466 DB - PRIME DP - Unbound Medicine ER -