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Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics.
Int J Biol Macromol. 2016 Nov; 92:972-980.IJ

Abstract

The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre- and post- compression parameters, and were characterized. The optimized PCMT (F14) formulation showed favorable in vitro release of PC (65%) in 12h, and the release kinetics followed zero order anomalous diffusion mechanism. AS gum exerted significant (p<0.001) anticancer activity with 98.25% inhibition at 2000μg/mL (IC50=179.12μg/mL) against A549 cell line. PC and PCMT showed 78.56% inhibition (IC50 value=856.58μg/mL) and 93.68% inhibition (IC50 value=396.35μg/mL) respectively, symbolizing that the gum remarkably potentiated the anticancer effect of PC in formulation after 24h treatment by inducing apoptosis. This is the first report on A. stipulata gum as a promising biopolymer for drug delivery application in cancer therapeutics.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India; National Facility for Drug Development (NFDD) for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India.Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences (RIPANS), Zemabawk, Aizawl 796017, Mizoram, India. Electronic address: aduhapc@gmail.com.Department of Pharmaceutical Technology, Centre for Excellence in Nanobio Translational Research (CENTRE), Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India; National Facility for Drug Development (NFDD) for Academia, Pharmaceutical and Allied Industries, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli 620024, Tamil Nadu, India. Electronic address: hodpharma@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27506120

Citation

T, Veenus Seelan, et al. "Design and Development of Albizia Stipulata Gum Based Controlled-release Matrix Tablets in Cancer Therapeutics." International Journal of Biological Macromolecules, vol. 92, 2016, pp. 972-980.
T VS, Henry LJ, Narra K, et al. Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics. Int J Biol Macromol. 2016;92:972-980.
T, V. S., Henry, L. J., Narra, K., Lalduhsanga, P., & Kandasamy, R. (2016). Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics. International Journal of Biological Macromolecules, 92, 972-980. https://doi.org/10.1016/j.ijbiomac.2016.08.006
T VS, et al. Design and Development of Albizia Stipulata Gum Based Controlled-release Matrix Tablets in Cancer Therapeutics. Int J Biol Macromol. 2016;92:972-980. PubMed PMID: 27506120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics. AU - T,Veenus Seelan, AU - Henry,Linda Jeeva Kumari, AU - Narra,Kishore, AU - Lalduhsanga,Pachuau, AU - Kandasamy,Ruckmani, Y1 - 2016/08/06/ PY - 2016/06/16/received PY - 2016/08/02/revised PY - 2016/08/03/accepted PY - 2016/8/11/pubmed PY - 2017/3/14/medline PY - 2016/8/11/entrez KW - Albizia stipulata gum KW - Anticancer KW - Controlled drug release KW - Matrix tablet KW - Paracetamol SP - 972 EP - 980 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 92 N2 - The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre- and post- compression parameters, and were characterized. The optimized PCMT (F14) formulation showed favorable in vitro release of PC (65%) in 12h, and the release kinetics followed zero order anomalous diffusion mechanism. AS gum exerted significant (p<0.001) anticancer activity with 98.25% inhibition at 2000μg/mL (IC50=179.12μg/mL) against A549 cell line. PC and PCMT showed 78.56% inhibition (IC50 value=856.58μg/mL) and 93.68% inhibition (IC50 value=396.35μg/mL) respectively, symbolizing that the gum remarkably potentiated the anticancer effect of PC in formulation after 24h treatment by inducing apoptosis. This is the first report on A. stipulata gum as a promising biopolymer for drug delivery application in cancer therapeutics. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/27506120/Design_and_development_of_Albizia_stipulata_gum_based_controlled_release_matrix_tablets_in_cancer_therapeutics_ DB - PRIME DP - Unbound Medicine ER -