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Effect of vitamin D3 supplementation on iron status: a randomized, double-blind, placebo-controlled trial among ethnic minorities living in Norway.
Nutr J. 2016 08 09; 15(1):74.NJ

Abstract

BACKGROUND

Both vitamin D and iron deficiencies are widespread globally, and a relationship between these deficiencies has been suggested. However, there is a paucity of randomised controlled trials assessing the effect of vitamin D supplementation on iron status.

PURPOSE

We aimed to investigate whether 16 weeks of daily vitamin D3 supplementation had an effect on serum ferritin, haemoglobin, serum iron and transferrin saturation.

METHODS

Overall, 251 participants from South Asia, Middle East and Africa aged 18-50 years who were living in Norway were randomised to receive daily oral supplementation of 10 μg vitamin D3, 25 μg vitamin D3, or placebo for 16 weeks during the late winter. Blood samples from baseline and after 16 weeks were analysed for serum 25-hydroxyvitamin D (s-25(OH) D), serum ferritin, haemoglobin and serum iron. In total, 214 eligible participants completed the intervention (86 % of those randomised). Linear regression analysis were used to test the effect of vitamin D3 supplementation combined (10 or 25 μg) and separate doses 10 or 25 μg compared to placebo on change (T2-T1) in each outcome variable adjusted for baseline s-25(OH)D values.

RESULTS

There was no difference in change in the levels of s-ferritin (1.9 μg/L, 95 % CI: -3.2, 7.0), haemoglobin (-0.02 g/dL, 95 % CI: -0.12, 0.09), s-iron (0.4 μg/L, 95 % CI: -0.5, 1.3) or transferrin saturation (0.7 %, 95 % CI: -0.6.1, 2.0) between those receiving vitamin D3 or those receiving placebo. Serum 25-hydroxyvitamin D increased from 29 nmol/L at baseline to 49 nmol/L after the intervention, with little change in the placebo group.

CONCLUSIONS

In this population of healthy ethnic minorities from South Asia, the Middle East and Africa who had low vitamin D status, 16 weeks of daily supplementation with 10 or 25 μg of vitamin D3 did not significantly affect the haemoglobin levels or other markers of iron status.

Authors+Show Affiliations

Department of Community Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway. a.a.madar@medisin.uio.no.Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.Department of Community Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway.Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway.Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27506667

Citation

Madar, Ahmed A., et al. "Effect of Vitamin D3 Supplementation On Iron Status: a Randomized, Double-blind, Placebo-controlled Trial Among Ethnic Minorities Living in Norway." Nutrition Journal, vol. 15, no. 1, 2016, p. 74.
Madar AA, Stene LC, Meyer HE, et al. Effect of vitamin D3 supplementation on iron status: a randomized, double-blind, placebo-controlled trial among ethnic minorities living in Norway. Nutr J. 2016;15(1):74.
Madar, A. A., Stene, L. C., Meyer, H. E., Brekke, M., Lagerløv, P., & Knutsen, K. V. (2016). Effect of vitamin D3 supplementation on iron status: a randomized, double-blind, placebo-controlled trial among ethnic minorities living in Norway. Nutrition Journal, 15(1), 74. https://doi.org/10.1186/s12937-016-0192-7
Madar AA, et al. Effect of Vitamin D3 Supplementation On Iron Status: a Randomized, Double-blind, Placebo-controlled Trial Among Ethnic Minorities Living in Norway. Nutr J. 2016 08 9;15(1):74. PubMed PMID: 27506667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin D3 supplementation on iron status: a randomized, double-blind, placebo-controlled trial among ethnic minorities living in Norway. AU - Madar,Ahmed A, AU - Stene,Lars C, AU - Meyer,Haakon E, AU - Brekke,Mette, AU - Lagerløv,Per, AU - Knutsen,Kirsten V, Y1 - 2016/08/09/ PY - 2016/03/18/received PY - 2016/07/28/accepted PY - 2016/8/11/entrez PY - 2016/8/11/pubmed PY - 2017/10/31/medline KW - Immigrants KW - Iron status KW - Randomised controlled trials KW - Vitamin D SP - 74 EP - 74 JF - Nutrition journal JO - Nutr J VL - 15 IS - 1 N2 - BACKGROUND: Both vitamin D and iron deficiencies are widespread globally, and a relationship between these deficiencies has been suggested. However, there is a paucity of randomised controlled trials assessing the effect of vitamin D supplementation on iron status. PURPOSE: We aimed to investigate whether 16 weeks of daily vitamin D3 supplementation had an effect on serum ferritin, haemoglobin, serum iron and transferrin saturation. METHODS: Overall, 251 participants from South Asia, Middle East and Africa aged 18-50 years who were living in Norway were randomised to receive daily oral supplementation of 10 μg vitamin D3, 25 μg vitamin D3, or placebo for 16 weeks during the late winter. Blood samples from baseline and after 16 weeks were analysed for serum 25-hydroxyvitamin D (s-25(OH) D), serum ferritin, haemoglobin and serum iron. In total, 214 eligible participants completed the intervention (86 % of those randomised). Linear regression analysis were used to test the effect of vitamin D3 supplementation combined (10 or 25 μg) and separate doses 10 or 25 μg compared to placebo on change (T2-T1) in each outcome variable adjusted for baseline s-25(OH)D values. RESULTS: There was no difference in change in the levels of s-ferritin (1.9 μg/L, 95 % CI: -3.2, 7.0), haemoglobin (-0.02 g/dL, 95 % CI: -0.12, 0.09), s-iron (0.4 μg/L, 95 % CI: -0.5, 1.3) or transferrin saturation (0.7 %, 95 % CI: -0.6.1, 2.0) between those receiving vitamin D3 or those receiving placebo. Serum 25-hydroxyvitamin D increased from 29 nmol/L at baseline to 49 nmol/L after the intervention, with little change in the placebo group. CONCLUSIONS: In this population of healthy ethnic minorities from South Asia, the Middle East and Africa who had low vitamin D status, 16 weeks of daily supplementation with 10 or 25 μg of vitamin D3 did not significantly affect the haemoglobin levels or other markers of iron status. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/27506667/Effect_of_vitamin_D3_supplementation_on_iron_status:_a_randomized_double_blind_placebo_controlled_trial_among_ethnic_minorities_living_in_Norway_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0192-7 DB - PRIME DP - Unbound Medicine ER -