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Omega-3 fatty acids from fish oils and cardiovascular disease.
Mol Cell Biochem 2004; 263(1):217-25MC

Abstract

Fish and fish oils contain the omega-3 fatty acids known as eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA). Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships have been substantiated from blood measures of omega-3 fatty acids including DHA as a physiological biomarker for omega-3 fatty acid status. Controlled intervention trials with fish oil supplements enriched in EPA/DHA have shown their potential to reduce mortality in post-myocardial infarction patients with a substantial reduction in the risk of sudden cardiac death. The cardioprotective effects of EPA/DHA are widespread, appear to act independently of blood cholesterol reduction, and are mediated by diverse mechanisms. Their overall effects include anti-arrhythmic, blood triglyceride-lowering, anti-thrombotic, anti-inflammatory, endothelial relaxation, plus others. Current dietary intakes of EPA/DHA in North America and elsewhere are well below those recommended by the American Heart Association for the management of patients with coronary heart disease. (Mol Cell Biochem 263: 217-225, 2004).

Authors+Show Affiliations

Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27520680

Citation

Holub, Darren J., and Bruce J. Holub. "Omega-3 Fatty Acids From Fish Oils and Cardiovascular Disease." Molecular and Cellular Biochemistry, vol. 263, no. 1, 2004, pp. 217-25.
Holub DJ, Holub BJ. Omega-3 fatty acids from fish oils and cardiovascular disease. Mol Cell Biochem. 2004;263(1):217-25.
Holub, D. J., & Holub, B. J. (2004). Omega-3 fatty acids from fish oils and cardiovascular disease. Molecular and Cellular Biochemistry, 263(1), pp. 217-25. doi:10.1023/B:MCBI.0000041863.11248.8d.
Holub DJ, Holub BJ. Omega-3 Fatty Acids From Fish Oils and Cardiovascular Disease. Mol Cell Biochem. 2004;263(1):217-25. PubMed PMID: 27520680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids from fish oils and cardiovascular disease. AU - Holub,Darren J, AU - Holub,Bruce J, PY - 2016/8/14/entrez PY - 2004/8/1/pubmed PY - 2004/8/1/medline KW - anti-arrhythmic KW - coronary heart disease KW - eicosapentaenoic (EPA) plus docosahexaenoic acid (DHA) KW - omega-3 fatty acids KW - secondary management KW - sudden cardiac death SP - 217 EP - 25 JF - Molecular and cellular biochemistry JO - Mol. Cell. Biochem. VL - 263 IS - 1 N2 - Fish and fish oils contain the omega-3 fatty acids known as eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA). Epidemiological studies have shown an inverse relation between the dietary consumption of fish containing EPA/DHA and mortality from coronary heart disease. These relationships have been substantiated from blood measures of omega-3 fatty acids including DHA as a physiological biomarker for omega-3 fatty acid status. Controlled intervention trials with fish oil supplements enriched in EPA/DHA have shown their potential to reduce mortality in post-myocardial infarction patients with a substantial reduction in the risk of sudden cardiac death. The cardioprotective effects of EPA/DHA are widespread, appear to act independently of blood cholesterol reduction, and are mediated by diverse mechanisms. Their overall effects include anti-arrhythmic, blood triglyceride-lowering, anti-thrombotic, anti-inflammatory, endothelial relaxation, plus others. Current dietary intakes of EPA/DHA in North America and elsewhere are well below those recommended by the American Heart Association for the management of patients with coronary heart disease. (Mol Cell Biochem 263: 217-225, 2004). SN - 0300-8177 UR - https://www.unboundmedicine.com/medline/citation/27520680/Omega_3_fatty_acids_from_fish_oils_and_cardiovascular_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=27520680.ui DB - PRIME DP - Unbound Medicine ER -