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Innate Immune Responses to Fungal Allergens.
Curr Allergy Asthma Rep. 2016 09; 16(9):62.CA

Abstract

PURPOSE OF REVIEW

In this review, we describe innate immunity to fungi and the ability of pattern recognition receptors (PRRs) to recognize fungal-associated molecular patterns (FAMPs) and danger-associated molecular patterns (DAMPs).

RECENT FINDINGS

Protective responses against fungal antigens can be divided into two parts: innate immunity and adaptive immunity. Detection of foreign substance by the innate immune system is mediated by a variety of genetically encoded receptors known as pattern recognition receptors (PRRs). These PRRs bind to PAMPs (pathogen-associated molecular patterns) and more specifically to fungal-associated molecular patterns or FAMPs on target microorganisms. They also bind to DAMPs (damage-associated molecular patterns) which are substances released due to tissue and cell damage. PRRs can be divided into several families including Toll-like receptors (TLRs), nucleotide-oligomerization domain (NOD)-like receptors (NLRs), and C-type lectin receptors. Fungal PRRs can respond to internal and external components found in fungi. In addition, a number of fungal products, including some fungal allergens, seem to mimic or represent DAMPs. Collectively, activation of these fungal PRRs alerts the innate immune system to the presence of fungal exposure and can promote both innate and adaptive immune responses.

Authors+Show Affiliations

Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA. Jportnoy@cmh.edu.Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27520938

Citation

Portnoy, Jay M., et al. "Innate Immune Responses to Fungal Allergens." Current Allergy and Asthma Reports, vol. 16, no. 9, 2016, p. 62.
Portnoy JM, Williams PB, Barnes CS. Innate Immune Responses to Fungal Allergens. Curr Allergy Asthma Rep. 2016;16(9):62.
Portnoy, J. M., Williams, P. B., & Barnes, C. S. (2016). Innate Immune Responses to Fungal Allergens. Current Allergy and Asthma Reports, 16(9), 62. https://doi.org/10.1007/s11882-016-0643-4
Portnoy JM, Williams PB, Barnes CS. Innate Immune Responses to Fungal Allergens. Curr Allergy Asthma Rep. 2016;16(9):62. PubMed PMID: 27520938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Innate Immune Responses to Fungal Allergens. AU - Portnoy,Jay M, AU - Williams,P Brock, AU - Barnes,Charles S, PY - 2016/8/14/entrez PY - 2016/8/16/pubmed PY - 2017/7/25/medline KW - Fungal immunity KW - Fungus KW - Innate immunity SP - 62 EP - 62 JF - Current allergy and asthma reports JO - Curr Allergy Asthma Rep VL - 16 IS - 9 N2 - PURPOSE OF REVIEW: In this review, we describe innate immunity to fungi and the ability of pattern recognition receptors (PRRs) to recognize fungal-associated molecular patterns (FAMPs) and danger-associated molecular patterns (DAMPs). RECENT FINDINGS: Protective responses against fungal antigens can be divided into two parts: innate immunity and adaptive immunity. Detection of foreign substance by the innate immune system is mediated by a variety of genetically encoded receptors known as pattern recognition receptors (PRRs). These PRRs bind to PAMPs (pathogen-associated molecular patterns) and more specifically to fungal-associated molecular patterns or FAMPs on target microorganisms. They also bind to DAMPs (damage-associated molecular patterns) which are substances released due to tissue and cell damage. PRRs can be divided into several families including Toll-like receptors (TLRs), nucleotide-oligomerization domain (NOD)-like receptors (NLRs), and C-type lectin receptors. Fungal PRRs can respond to internal and external components found in fungi. In addition, a number of fungal products, including some fungal allergens, seem to mimic or represent DAMPs. Collectively, activation of these fungal PRRs alerts the innate immune system to the presence of fungal exposure and can promote both innate and adaptive immune responses. SN - 1534-6315 UR - https://www.unboundmedicine.com/medline/citation/27520938/Innate_Immune_Responses_to_Fungal_Allergens_ L2 - https://dx.doi.org/10.1007/s11882-016-0643-4 DB - PRIME DP - Unbound Medicine ER -
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