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Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow.
Auton Neurosci. 2017 05; 204:57-64.AN

Abstract

The sympathetic nervous system has been identified as a major contributor to the pathophysiology of chronic heart failure (CHF) and other diseases such as hypertension and diabetes, both in experimental animal models and patients. The kidneys have a dense afferent sensory innervation positioning it to be the origin of multimodal input to the central nervous system. Afferent renal nerve (ARN) signals are centrally integrated, and their activation results in a general increase in sympathetic tone, which is directed toward the kidneys as well as other peripheral organs innervated by the sympathetic nerves. In the central nervous system, stimulation of ARN increases the neuronal discharge frequency and neuronal activity in the paraventricular nucleus (PVN) of the hypothalamus. The activity of the neurons in the PVN is attenuated during iontophoretic application of glutamate receptor blocker, AP5. An enhanced afferent renal input to the PVN may be critically involved in dictating sympathoexcitation in CHF. Furthermore, renal denervation abrogates the enhanced neuronal activity within the PVN in rats with CHF, thereby possibly contributing to the reduction in sympathetic tone. Renal denervation also restores the decreased endogenous levels of neuronal nitric oxide synthase (nNOS) in the PVN of rats with CHF. Overall, these data demonstrate that sensory information originating in the kidney excites pre-autonomic sympathetic neurons within the PVN and this "renal-PVN afferent pathway" may contribute to elevated sympathetic nerve activity in hyper-sympathetic disease conditions such as CHF and hypertension.

Authors+Show Affiliations

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, United States.Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, United States. Electronic address: kpatel@unmc.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27527558

Citation

Zheng, Hong, and Kaushik P. Patel. "Integration of Renal Sensory Afferents at the Level of the Paraventricular Nucleus Dictating Sympathetic Outflow." Autonomic Neuroscience : Basic & Clinical, vol. 204, 2017, pp. 57-64.
Zheng H, Patel KP. Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow. Auton Neurosci. 2017;204:57-64.
Zheng, H., & Patel, K. P. (2017). Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow. Autonomic Neuroscience : Basic & Clinical, 204, 57-64. https://doi.org/10.1016/j.autneu.2016.08.008
Zheng H, Patel KP. Integration of Renal Sensory Afferents at the Level of the Paraventricular Nucleus Dictating Sympathetic Outflow. Auton Neurosci. 2017;204:57-64. PubMed PMID: 27527558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow. AU - Zheng,Hong, AU - Patel,Kaushik P, Y1 - 2016/08/06/ PY - 2016/05/20/received PY - 2016/08/01/revised PY - 2016/08/05/accepted PY - 2016/8/17/pubmed PY - 2017/8/22/medline PY - 2016/8/17/entrez KW - Afferent renal nerves KW - Cardiovascular KW - Paraventricular nucleus KW - Sympathetic activity SP - 57 EP - 64 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 204 N2 - The sympathetic nervous system has been identified as a major contributor to the pathophysiology of chronic heart failure (CHF) and other diseases such as hypertension and diabetes, both in experimental animal models and patients. The kidneys have a dense afferent sensory innervation positioning it to be the origin of multimodal input to the central nervous system. Afferent renal nerve (ARN) signals are centrally integrated, and their activation results in a general increase in sympathetic tone, which is directed toward the kidneys as well as other peripheral organs innervated by the sympathetic nerves. In the central nervous system, stimulation of ARN increases the neuronal discharge frequency and neuronal activity in the paraventricular nucleus (PVN) of the hypothalamus. The activity of the neurons in the PVN is attenuated during iontophoretic application of glutamate receptor blocker, AP5. An enhanced afferent renal input to the PVN may be critically involved in dictating sympathoexcitation in CHF. Furthermore, renal denervation abrogates the enhanced neuronal activity within the PVN in rats with CHF, thereby possibly contributing to the reduction in sympathetic tone. Renal denervation also restores the decreased endogenous levels of neuronal nitric oxide synthase (nNOS) in the PVN of rats with CHF. Overall, these data demonstrate that sensory information originating in the kidney excites pre-autonomic sympathetic neurons within the PVN and this "renal-PVN afferent pathway" may contribute to elevated sympathetic nerve activity in hyper-sympathetic disease conditions such as CHF and hypertension. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/27527558/Integration_of_renal_sensory_afferents_at_the_level_of_the_paraventricular_nucleus_dictating_sympathetic_outflow_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(16)30131-X DB - PRIME DP - Unbound Medicine ER -