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The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults.
Proc Nutr Soc. 2017 02; 76(1):64-75.PN

Abstract

The aim of this review was to determine the impact of the fatty acid desaturase (FADS) genotype on plasma and tissue concentrations of the long-chain (LC) n-3 PUFA, including EPA and DHA, which are associated with the risk of several diet-related chronic diseases, including CVD. In addition to dietary intakes, which are low for many individuals, tissue EPA and DHA are also influenced by the rate of bioconversion from α-linolenic acid (αLNA). Δ-5 and Δ-6 desaturase enzymes, encoded for by FADS1 and FADS2 genes, are key desaturation enzymes involved in the bioconversion of essential fatty acids (αLNA and linoleic acid (LA)) to longer chained PUFA. In general, carriers of FADS minor alleles tend to have higher habitual plasma and tissue levels of LA and αLNA, and lower levels of arachidonic acid, EPA and also to a lesser extent DHA. In conclusion, available research findings suggest that FADS minor alleles are also associated with reduced inflammation and CVD risk, and that dietary total fat and fatty acid intake have the potential to modify relationships between FADS gene variants and circulating fatty acid levels. However to date, neither the size-effects of FADS variants on fatty acid status, nor the functional SNP in FADS1 and 2 have been identified. Such information could contribute to the refinement and targeting of EPA and DHA recommendations, whereby additional LC n-3 PUFA intakes could be recommended for those carrying FADS minor alleles.

Authors+Show Affiliations

Department of Nutrition and Preventive Medicine,Norwich Medical School,BCRE,University of East Anglia,James Watson Road,Norwich NR4 7UQ,UK.Department of Nutrition and Preventive Medicine,Norwich Medical School,BCRE,University of East Anglia,James Watson Road,Norwich NR4 7UQ,UK.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27527582

Citation

O'Neill, Colette M., and Anne-Marie Minihane. "The Impact of Fatty Acid Desaturase Genotype On Fatty Acid Status and Cardiovascular Health in Adults." The Proceedings of the Nutrition Society, vol. 76, no. 1, 2017, pp. 64-75.
O'Neill CM, Minihane AM. The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults. Proc Nutr Soc. 2017;76(1):64-75.
O'Neill, C. M., & Minihane, A. M. (2017). The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults. The Proceedings of the Nutrition Society, 76(1), 64-75. https://doi.org/10.1017/S0029665116000732
O'Neill CM, Minihane AM. The Impact of Fatty Acid Desaturase Genotype On Fatty Acid Status and Cardiovascular Health in Adults. Proc Nutr Soc. 2017;76(1):64-75. PubMed PMID: 27527582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults. AU - O'Neill,Colette M, AU - Minihane,Anne-Marie, Y1 - 2016/08/16/ PY - 2016/8/17/pubmed PY - 2017/11/29/medline PY - 2016/8/17/entrez KW - FADS KW - AA arachidonic acid KW - FADS fatty acid desaturase KW - LA linoleic acid KW - LC long-chain KW - αLNA α-linolenic acid KW - Arachidonic acid KW - CVD KW - Cardiovascular KW - DHA KW - EPA KW - Genotype KW - Long-chain PUFA SP - 64 EP - 75 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 76 IS - 1 N2 - The aim of this review was to determine the impact of the fatty acid desaturase (FADS) genotype on plasma and tissue concentrations of the long-chain (LC) n-3 PUFA, including EPA and DHA, which are associated with the risk of several diet-related chronic diseases, including CVD. In addition to dietary intakes, which are low for many individuals, tissue EPA and DHA are also influenced by the rate of bioconversion from α-linolenic acid (αLNA). Δ-5 and Δ-6 desaturase enzymes, encoded for by FADS1 and FADS2 genes, are key desaturation enzymes involved in the bioconversion of essential fatty acids (αLNA and linoleic acid (LA)) to longer chained PUFA. In general, carriers of FADS minor alleles tend to have higher habitual plasma and tissue levels of LA and αLNA, and lower levels of arachidonic acid, EPA and also to a lesser extent DHA. In conclusion, available research findings suggest that FADS minor alleles are also associated with reduced inflammation and CVD risk, and that dietary total fat and fatty acid intake have the potential to modify relationships between FADS gene variants and circulating fatty acid levels. However to date, neither the size-effects of FADS variants on fatty acid status, nor the functional SNP in FADS1 and 2 have been identified. Such information could contribute to the refinement and targeting of EPA and DHA recommendations, whereby additional LC n-3 PUFA intakes could be recommended for those carrying FADS minor alleles. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/27527582/The_impact_of_fatty_acid_desaturase_genotype_on_fatty_acid_status_and_cardiovascular_health_in_adults_ L2 - https://www.cambridge.org/core/product/identifier/S0029665116000732/type/journal_article DB - PRIME DP - Unbound Medicine ER -