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Neuroprotective Effects of Quercetin: From Chemistry to Medicine.
CNS Neurol Disord Drug Targets. 2016; 15(8):964-975.CN

Abstract

Neurodegenerative diseases are the leading cause of disability in the elderly. Growing evidence suggests that oxidative stress, which is associated with aging, is the basis of most neurodegenerative disorders; and polyphenols, acting as antioxidant agents, reduce the risk of neurodegenerative diseases. Quercetin is a flavonoid occurring in many plant foods commonly consumed as part of a regular diet. It shows a number of biological properties connected to its antioxidant activity. This review assesses the molecular structure of quercetin, its food sources and bioavailability. Moreover, the main results obtained from in vitro studies, observing the mechanisms of action through which quercetin exerts its antioxidant activity, are reported. However, most of these effects have only been observed in vitro and clinical studies are lacking.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableApplied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran. Nabavi208@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27528470

Citation

Barreca, Davide, et al. "Neuroprotective Effects of Quercetin: From Chemistry to Medicine." CNS & Neurological Disorders Drug Targets, vol. 15, no. 8, 2016, pp. 964-975.
Barreca D, Bellocco E, D'Onofrio G, et al. Neuroprotective Effects of Quercetin: From Chemistry to Medicine. CNS Neurol Disord Drug Targets. 2016;15(8):964-975.
Barreca, D., Bellocco, E., D'Onofrio, G., Nabavi, S. F., Daglia, M., Rastrelli, L., & Nabavi, S. M. (2016). Neuroprotective Effects of Quercetin: From Chemistry to Medicine. CNS & Neurological Disorders Drug Targets, 15(8), 964-975.
Barreca D, et al. Neuroprotective Effects of Quercetin: From Chemistry to Medicine. CNS Neurol Disord Drug Targets. 2016;15(8):964-975. PubMed PMID: 27528470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effects of Quercetin: From Chemistry to Medicine. AU - Barreca,Davide, AU - Bellocco,Ersilia, AU - D'Onofrio,Grazia, AU - Nabavi,Seyed Fazel, AU - Daglia,Maria, AU - Rastrelli,Luca, AU - Nabavi,Seyed Mohammad, PY - 2015/09/20/received PY - 2016/06/16/revised PY - 2016/08/03/accepted PY - 2016/8/17/pubmed PY - 2017/10/11/medline PY - 2016/8/17/entrez SP - 964 EP - 975 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 15 IS - 8 N2 - Neurodegenerative diseases are the leading cause of disability in the elderly. Growing evidence suggests that oxidative stress, which is associated with aging, is the basis of most neurodegenerative disorders; and polyphenols, acting as antioxidant agents, reduce the risk of neurodegenerative diseases. Quercetin is a flavonoid occurring in many plant foods commonly consumed as part of a regular diet. It shows a number of biological properties connected to its antioxidant activity. This review assesses the molecular structure of quercetin, its food sources and bioavailability. Moreover, the main results obtained from in vitro studies, observing the mechanisms of action through which quercetin exerts its antioxidant activity, are reported. However, most of these effects have only been observed in vitro and clinical studies are lacking. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/27528470/Neuroprotective_Effects_of_Quercetin:_From_Chemistry_to_Medicine_ DB - PRIME DP - Unbound Medicine ER -