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Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid.
Eur J Nutr. 2017 Dec; 56(8):2541-2556.EJ

Abstract

PURPOSE

Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and chimarrão (green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are scarce. The aim of this study was to investigate the distribution of CGAs and metabolites in tissues, hepatic and plasmatic kinetic profile and urinary excretion after ingestion of maté tea or 5-caffeoylquinic acid (5-CQA).

METHODS

Wistar rats ingested maté tea (MT) or 5-CQA (ST) and were killed after 1.5 h for tissue distribution analysis (pilot study) or at 0.5, 1, 2, 4 and 8 h for liver and plasma kinetics (main experiment). Urine was collected in metabolic cages. Biological samples were analyzed by UPLC-DAD-MS with and without incubation with β-glucuronidase and sulfatase.

RESULTS

CGAs and metabolites were detected in all tissues. Caffeic acid was the main compound in plasma up to 2 h after ingestion of maté tea, while 5-CQA predominated in ST group. Concentration of microbial metabolites increased 4 h after gavage and reached higher amounts in MT plasma and liver, when compared to ST group. Approximately 4.0 % of compounds ingested by MT and 3.3 % by ST were recovered in urine up to 8 h after the gavage.

CONCLUSION

The study confirms that not only absorption, but also metabolization of CGAs begins in stomach. There were differences in compounds formed from maté tea or isolated 5-CQA, showing that CGAs profile in food may influence qualitatively and quantitatively the metabolites formed in the body.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

de Oliveira DM
Nutrition Department, School of Public Health, University of São Paulo, Av Dr Arnaldo 715, São Paulo, SP, CEP 01246-904, Brazil.
Sampaio GR
Nutrition Department, School of Public Health, University of São Paulo, Av Dr Arnaldo 715, São Paulo, SP, CEP 01246-904, Brazil.
Pinto CB
Nutrition Department, School of Public Health, University of São Paulo, Av Dr Arnaldo 715, São Paulo, SP, CEP 01246-904, Brazil.
Catharino RR
INNOVARE Biomarkers Laboratory, School of Medical Sciences, University of Campinas, Rua: Tessália Vieira de Camargo, 126, Cidade Universitária "Zeferino Vaz", Campinas, SP, CEP 13083-887, Brazil.
Bastos DHM
Nutrition Department, School of Public Health, University of São Paulo, Av Dr Arnaldo 715, São Paulo, SP, CEP 01246-904, Brazil. dmbastos@usp.br.

MeSH

AnimalsBiological AvailabilityCaffeic AcidsChlorogenic AcidIlex paraguariensisPlant ExtractsPlant LeavesPolyphenolsQuinic AcidRatsRats, WistarSouth AmericaTeas, Herbal

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27535559

Citation

de Oliveira, Daniela Moura, et al. "Bioavailability of Chlorogenic Acids in Rats After Acute Ingestion of Maté Tea (Ilex Paraguariensis) or 5-caffeoylquinic Acid." European Journal of Nutrition, vol. 56, no. 8, 2017, pp. 2541-2556.
de Oliveira DM, Sampaio GR, Pinto CB, et al. Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid. Eur J Nutr. 2017;56(8):2541-2556.
de Oliveira, D. M., Sampaio, G. R., Pinto, C. B., Catharino, R. R., & Bastos, D. H. M. (2017). Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid. European Journal of Nutrition, 56(8), 2541-2556. https://doi.org/10.1007/s00394-016-1290-1
de Oliveira DM, et al. Bioavailability of Chlorogenic Acids in Rats After Acute Ingestion of Maté Tea (Ilex Paraguariensis) or 5-caffeoylquinic Acid. Eur J Nutr. 2017;56(8):2541-2556. PubMed PMID: 27535559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid. AU - de Oliveira,Daniela Moura, AU - Sampaio,Geni Rodrigues, AU - Pinto,Carolina Bonin, AU - Catharino,Rodrigo Ramos, AU - Bastos,Deborah H Markowicz, Y1 - 2016/08/17/ PY - 2015/08/28/received PY - 2016/08/02/accepted PY - 2016/8/19/pubmed PY - 2018/7/13/medline PY - 2016/8/19/entrez KW - Bioavailability KW - Biotransformation KW - Chlorogenic acids KW - Ilex paraguariensis KW - Phenolic compounds KW - UPLC-DAD-MS SP - 2541 EP - 2556 JF - European journal of nutrition JO - Eur J Nutr VL - 56 IS - 8 N2 - PURPOSE: Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and chimarrão (green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are scarce. The aim of this study was to investigate the distribution of CGAs and metabolites in tissues, hepatic and plasmatic kinetic profile and urinary excretion after ingestion of maté tea or 5-caffeoylquinic acid (5-CQA). METHODS: Wistar rats ingested maté tea (MT) or 5-CQA (ST) and were killed after 1.5 h for tissue distribution analysis (pilot study) or at 0.5, 1, 2, 4 and 8 h for liver and plasma kinetics (main experiment). Urine was collected in metabolic cages. Biological samples were analyzed by UPLC-DAD-MS with and without incubation with β-glucuronidase and sulfatase. RESULTS: CGAs and metabolites were detected in all tissues. Caffeic acid was the main compound in plasma up to 2 h after ingestion of maté tea, while 5-CQA predominated in ST group. Concentration of microbial metabolites increased 4 h after gavage and reached higher amounts in MT plasma and liver, when compared to ST group. Approximately 4.0 % of compounds ingested by MT and 3.3 % by ST were recovered in urine up to 8 h after the gavage. CONCLUSION: The study confirms that not only absorption, but also metabolization of CGAs begins in stomach. There were differences in compounds formed from maté tea or isolated 5-CQA, showing that CGAs profile in food may influence qualitatively and quantitatively the metabolites formed in the body. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/27535559/Bioavailability_of_chlorogenic_acids_in_rats_after_acute_ingestion_of_mat��_tea__Ilex_paraguariensis__or_5_caffeoylquinic_acid_ DB - PRIME DP - Unbound Medicine ER -