Tags

Type your tag names separated by a space and hit enter

The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer.
Springerplus. 2016; 5(1):1244.S

Abstract

Leptomeningeal metastasis (LM) is a terminal event in the development of non-small cell lung cancer (NSCLC). It has a poor prognosis with median survival of 1.9 months if untreated. The improvement of OS in NSCLC patients relatively increases incidence of LM. While current therapeutic options for LM are limited. Epidermal growth factor receptor-tyrosine kinase inhibitors are a class of small molecules and show dramatic response in epidermal growth factor receptor mutated patients. It also has a distinct therapeutic potential against brain metastases. Although there are some studies on EGFR-TKIs and brain metastases, the role of EGFR-TKIs on LM are not fully clarified. In this review, we will summarize current evidences concerning the use and discuss the role of EGFR-TKIs on LM.

Authors+Show Affiliations

School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China. Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China. Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China. Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China. Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.School of Medicine, Jiaxing University, Jiaxing, 314000 Zhejiang People's Republic of China. Department of Oncology, The First Affiliated Hospital of Jiaxing University, No. 1882, Zhonghuan South Road, Jiaxing, 314000 Zhejiang People's Republic of China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27536527

Citation

Yufen, Xu, et al. "The Role of EGFR-TKI for Leptomeningeal Metastases From Non-small Cell Lung Cancer." SpringerPlus, vol. 5, no. 1, 2016, p. 1244.
Yufen X, Binbin S, Wenyu C, et al. The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer. Springerplus. 2016;5(1):1244.
Yufen, X., Binbin, S., Wenyu, C., Jialiang, L., & Xinmei, Y. (2016). The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer. SpringerPlus, 5(1), 1244. https://doi.org/10.1186/s40064-016-2873-2
Yufen X, et al. The Role of EGFR-TKI for Leptomeningeal Metastases From Non-small Cell Lung Cancer. Springerplus. 2016;5(1):1244. PubMed PMID: 27536527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of EGFR-TKI for leptomeningeal metastases from non-small cell lung cancer. AU - Yufen,Xu, AU - Binbin,Song, AU - Wenyu,Chen, AU - Jialiang,Liu, AU - Xinmei,Yang, Y1 - 2016/08/03/ PY - 2015/11/02/received PY - 2016/07/19/accepted PY - 2016/8/19/entrez PY - 2016/8/19/pubmed PY - 2016/8/19/medline KW - EGFR-TKIs KW - Leptomeningeal metastasis KW - Non-small cell lung cancer SP - 1244 EP - 1244 JF - SpringerPlus JO - Springerplus VL - 5 IS - 1 N2 - Leptomeningeal metastasis (LM) is a terminal event in the development of non-small cell lung cancer (NSCLC). It has a poor prognosis with median survival of 1.9 months if untreated. The improvement of OS in NSCLC patients relatively increases incidence of LM. While current therapeutic options for LM are limited. Epidermal growth factor receptor-tyrosine kinase inhibitors are a class of small molecules and show dramatic response in epidermal growth factor receptor mutated patients. It also has a distinct therapeutic potential against brain metastases. Although there are some studies on EGFR-TKIs and brain metastases, the role of EGFR-TKIs on LM are not fully clarified. In this review, we will summarize current evidences concerning the use and discuss the role of EGFR-TKIs on LM. SN - 2193-1801 UR - https://www.unboundmedicine.com/medline/citation/27536527/The_role_of_EGFR_TKI_for_leptomeningeal_metastases_from_non_small_cell_lung_cancer_ L2 - https://dx.doi.org/10.1186/s40064-016-2873-2 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.