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Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results from a Large Population-Based Cohort Study in Austria.
PLoS One. 2016; 11(8):e0161376.Plos

Abstract

BACKGROUND

Anthropometric and metabolic risk factors for all-cause end-stage renal disease (ESRD) may vary in their impact depending on the specific primary renal disease.

METHODS

In this Austrian population-based prospective cohort study (n = 185,341; 53.9% women) the following data were collected between 1985 and 2005: age, sex, body mass index (BMI), fasting blood glucose (FBG) from 1988, blood pressure, total cholesterol (TC), triglycerides (TG), gamma-glutamyl transferase (GGT) and smoking status. These data were merged with the Austrian Dialysis and Transplant Registry to identify ESRD patients. Cox proportional hazards models were applied to calculate hazard ratios (HR) for all-cause ESRD as well as for cause-specific ESRD due to the following primary renal diseases: autosomal dominant polycystic kidney disease (ADPKD), vascular nephropathy (VN), diabetic nephropathy (DN) and other diseases (OD).

RESULTS

During a mean follow-up of 17.5 years 403 participants developed ESRD (ADPKD 36, VN 97, DN 86, and OD 184). All parameters except TG and GGT were significantly associated with all-cause ESRD risk. Particular cause-specific ESRD risk factor patterns were found: for ADPKD increased risk from hypertension (HR 11.55); for VN from smoking (HR 1.81), hypertension (HR 2.37), TG (≥5.70 vs. <1.17 mmol/L: HR 9.27); for DN from smoking (HR 1.77), BMI (≥30 vs. 18.5-24.9 kg/m2: HR 7.55), FBG (≥6.94 vs. <5.55 mmol/L: HR 7.67), hypertension (HR 1.08), TG (≥5.70 vs. <1.17 mmol/L: HR 2.02), GGT (HR 2.14); and for OD from hypertension (HR 2.29), TG (≥5.70 vs. <1.17 mmol/L: HR 6.99) and TC (≥6.22 vs. <5.18 mmol/L: HR 1.56).

CONCLUSIONS

Particular anthropometric and metabolic ESRD risk factors differ in importance depending on the primary renal disease. This needs to be considered for future preventive and therapeutic strategies addressing cause-specific ESRD.

Authors+Show Affiliations

Department of Nephrology and Dialysis, Academic Teaching Hospital Feldkirch, Feldkirch, Austria. Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Academic Teaching Hospital Feldkirch, Feldkirch, Austria.Agency for Preventive and Social Medicine, Bregenz, Austria. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.Agency for Preventive and Social Medicine, Bregenz, Austria.Austrian Dialysis and Transplant Registry, Rohr im Kremstal, Austria.Department of Nephrology and Dialysis, Academic Teaching Hospital Feldkirch, Feldkirch, Austria. Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Academic Teaching Hospital Feldkirch, Feldkirch, Austria.Agency for Preventive and Social Medicine, Bregenz, Austria. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27537361

Citation

Zitt, Emanuel, et al. "Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results From a Large Population-Based Cohort Study in Austria." PloS One, vol. 11, no. 8, 2016, pp. e0161376.
Zitt E, Pscheidt C, Concin H, et al. Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results from a Large Population-Based Cohort Study in Austria. PLoS ONE. 2016;11(8):e0161376.
Zitt, E., Pscheidt, C., Concin, H., Kramar, R., Lhotta, K., & Nagel, G. (2016). Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results from a Large Population-Based Cohort Study in Austria. PloS One, 11(8), e0161376. https://doi.org/10.1371/journal.pone.0161376
Zitt E, et al. Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results From a Large Population-Based Cohort Study in Austria. PLoS ONE. 2016;11(8):e0161376. PubMed PMID: 27537361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric and Metabolic Risk Factors for ESRD Are Disease-Specific: Results from a Large Population-Based Cohort Study in Austria. AU - Zitt,Emanuel, AU - Pscheidt,Constanze, AU - Concin,Hans, AU - Kramar,Reinhard, AU - Lhotta,Karl, AU - Nagel,Gabriele, Y1 - 2016/08/18/ PY - 2016/04/25/received PY - 2016/08/04/accepted PY - 2016/8/19/entrez PY - 2016/8/19/pubmed PY - 2017/7/27/medline SP - e0161376 EP - e0161376 JF - PloS one JO - PLoS ONE VL - 11 IS - 8 N2 - BACKGROUND: Anthropometric and metabolic risk factors for all-cause end-stage renal disease (ESRD) may vary in their impact depending on the specific primary renal disease. METHODS: In this Austrian population-based prospective cohort study (n = 185,341; 53.9% women) the following data were collected between 1985 and 2005: age, sex, body mass index (BMI), fasting blood glucose (FBG) from 1988, blood pressure, total cholesterol (TC), triglycerides (TG), gamma-glutamyl transferase (GGT) and smoking status. These data were merged with the Austrian Dialysis and Transplant Registry to identify ESRD patients. Cox proportional hazards models were applied to calculate hazard ratios (HR) for all-cause ESRD as well as for cause-specific ESRD due to the following primary renal diseases: autosomal dominant polycystic kidney disease (ADPKD), vascular nephropathy (VN), diabetic nephropathy (DN) and other diseases (OD). RESULTS: During a mean follow-up of 17.5 years 403 participants developed ESRD (ADPKD 36, VN 97, DN 86, and OD 184). All parameters except TG and GGT were significantly associated with all-cause ESRD risk. Particular cause-specific ESRD risk factor patterns were found: for ADPKD increased risk from hypertension (HR 11.55); for VN from smoking (HR 1.81), hypertension (HR 2.37), TG (≥5.70 vs. <1.17 mmol/L: HR 9.27); for DN from smoking (HR 1.77), BMI (≥30 vs. 18.5-24.9 kg/m2: HR 7.55), FBG (≥6.94 vs. <5.55 mmol/L: HR 7.67), hypertension (HR 1.08), TG (≥5.70 vs. <1.17 mmol/L: HR 2.02), GGT (HR 2.14); and for OD from hypertension (HR 2.29), TG (≥5.70 vs. <1.17 mmol/L: HR 6.99) and TC (≥6.22 vs. <5.18 mmol/L: HR 1.56). CONCLUSIONS: Particular anthropometric and metabolic ESRD risk factors differ in importance depending on the primary renal disease. This needs to be considered for future preventive and therapeutic strategies addressing cause-specific ESRD. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27537361/Anthropometric_and_Metabolic_Risk_Factors_for_ESRD_Are_Disease_Specific:_Results_from_a_Large_Population_Based_Cohort_Study_in_Austria_ L2 - http://dx.plos.org/10.1371/journal.pone.0161376 DB - PRIME DP - Unbound Medicine ER -