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Familial occurrence of headache disorders: A population-based study in mainland China.
Clin Neurol Neurosurg. 2016 Oct; 149:143-6.CN

Abstract

BACKGROUND

Headache disorders are highly prevalent worldwide, and familial occurrence and heredity are contributory factors attracting the interest of epidemiological researchers. Our purpose, in a large sample drawn nationwide from the Chinese general population, was to evaluate the frequency of similar headache in first-degree relatives (FDRs) of those with different headache types.

METHODS

This was a questionnaire-based nationwide cross-sectional door-to-door survey using cluster random-sampling, selecting one adult (18-65 years) per household. Headache was diagnosed by ICHD-II criteria. Participants with headache were asked whether or not any FDRs had similar headache to their own. Chi-squared test and multivariate logistic regression analysis were used to assess the strength and significance of associations.

RESULTS

Of 5041 survey participants (participation rate 94.1%), 1060 (21.0%) were diagnosed with headache (migraine 469 [9.3%], tension-type headache [TTH] 543 [10.8%], headache on ≥15 days/month 48 [0.95%]). From these, 31 were excluded because of missing data about FDRs, leaving 1029 for analysis (male 350 [mean age: 46.7±11.4years]; female 679 [mean age 46.3±11.2years]). Similar headache in one or more FDRs was reported by 22.2% (95% CI: 19.6-24.7%) overall, by 25.1% (21.1-29.1%) of those with migraine, by 19.1% (15.7-22.4%) with TTH and by 29.2% (16.3-42.0%) with headache on ≥15 days/month. The differences was significant between migraine and TTH (OR=1.4, p=0.023), but were not significant between headache on ≥15 days/month and TTH (OR=1.7, p=0.093), migraine and headache on ≥15 days/month (OR=1.2,p=0.534). In multivariate analysis: for migraine versus TTH,AOR=1.2 (p=0.015); for headache on ≥15 days/month versus TTH, AOR 2.3 (p=0.018).

CONCLUSION

Headache was highly prevalent in China and common among FDRs of those with any type of headache (headache on ≥15 days/month>migraine>TTH). Against the background of the general-population prevalence of each disorder, familial occurrence was a very highly influential factor in headache on ≥15 days/month. There are important implications in this for public health and education.

Authors+Show Affiliations

Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, 100853 Beijing, China. Electronic address: hemianwang@hotmail.com.Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, 100853 Beijing, China. Electronic address: yusy1963@126.com.Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, 100853 Beijing, China. Electronic address: liurz301@sina.com.Department of Neurology, Xiangya Hospital, Central-South University, Changsha, Hunan Province, China. Electronic address: sjnk_xy@yahoo.com.cn.Department of Neurology, The Fourth Military Medical University, Xian, Shaanxi Province, China. Electronic address: fmmuzhaogang@163.com.Department of Neurology, Affiliated Huashan Hospital of Fudan University, Shanghai, China. Electronic address: qiaoxy@yahoo.com.Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, China. Electronic address: fengjcfrank@yahoo.com.cn.Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China. Electronic address: fangyannan@21cn.com.Department of Health and Economics, Chinese PLA General Hospital, Beijing, China. Electronic address: xtcao@sina.com.Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: t.steiner@imperial.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27540755

Citation

He, Mianwang, et al. "Familial Occurrence of Headache Disorders: a Population-based Study in Mainland China." Clinical Neurology and Neurosurgery, vol. 149, 2016, pp. 143-6.
He M, Yu S, Liu R, et al. Familial occurrence of headache disorders: A population-based study in mainland China. Clin Neurol Neurosurg. 2016;149:143-6.
He, M., Yu, S., Liu, R., Yang, X., Zhao, G., Qiao, X., Feng, J., Fang, Y., Cao, X., & Steiner, T. J. (2016). Familial occurrence of headache disorders: A population-based study in mainland China. Clinical Neurology and Neurosurgery, 149, 143-6. https://doi.org/10.1016/j.clineuro.2016.08.010
He M, et al. Familial Occurrence of Headache Disorders: a Population-based Study in Mainland China. Clin Neurol Neurosurg. 2016;149:143-6. PubMed PMID: 27540755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial occurrence of headache disorders: A population-based study in mainland China. AU - He,Mianwang, AU - Yu,Shengyuan, AU - Liu,Ruozhuo, AU - Yang,Xiaosu, AU - Zhao,Gang, AU - Qiao,Xiangyang, AU - Feng,Jiachun, AU - Fang,Yannan, AU - Cao,Xiutang, AU - Steiner,Timothy J, Y1 - 2016/08/11/ PY - 2016/06/12/received PY - 2016/08/09/revised PY - 2016/08/10/accepted PY - 2016/8/20/entrez PY - 2016/8/20/pubmed PY - 2017/3/16/medline KW - China KW - First-degree relatives KW - Global campaign against headache KW - Headache KW - Heredity KW - Lifestyle KW - Population-based survey SP - 143 EP - 6 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 149 N2 - BACKGROUND: Headache disorders are highly prevalent worldwide, and familial occurrence and heredity are contributory factors attracting the interest of epidemiological researchers. Our purpose, in a large sample drawn nationwide from the Chinese general population, was to evaluate the frequency of similar headache in first-degree relatives (FDRs) of those with different headache types. METHODS: This was a questionnaire-based nationwide cross-sectional door-to-door survey using cluster random-sampling, selecting one adult (18-65 years) per household. Headache was diagnosed by ICHD-II criteria. Participants with headache were asked whether or not any FDRs had similar headache to their own. Chi-squared test and multivariate logistic regression analysis were used to assess the strength and significance of associations. RESULTS: Of 5041 survey participants (participation rate 94.1%), 1060 (21.0%) were diagnosed with headache (migraine 469 [9.3%], tension-type headache [TTH] 543 [10.8%], headache on ≥15 days/month 48 [0.95%]). From these, 31 were excluded because of missing data about FDRs, leaving 1029 for analysis (male 350 [mean age: 46.7±11.4years]; female 679 [mean age 46.3±11.2years]). Similar headache in one or more FDRs was reported by 22.2% (95% CI: 19.6-24.7%) overall, by 25.1% (21.1-29.1%) of those with migraine, by 19.1% (15.7-22.4%) with TTH and by 29.2% (16.3-42.0%) with headache on ≥15 days/month. The differences was significant between migraine and TTH (OR=1.4, p=0.023), but were not significant between headache on ≥15 days/month and TTH (OR=1.7, p=0.093), migraine and headache on ≥15 days/month (OR=1.2,p=0.534). In multivariate analysis: for migraine versus TTH,AOR=1.2 (p=0.015); for headache on ≥15 days/month versus TTH, AOR 2.3 (p=0.018). CONCLUSION: Headache was highly prevalent in China and common among FDRs of those with any type of headache (headache on ≥15 days/month>migraine>TTH). Against the background of the general-population prevalence of each disorder, familial occurrence was a very highly influential factor in headache on ≥15 days/month. There are important implications in this for public health and education. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/27540755/Familial_occurrence_of_headache_disorders:_A_population_based_study_in_mainland_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(16)30294-3 DB - PRIME DP - Unbound Medicine ER -