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Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly.

Abstract

The presence of Alzheimer's disease (AD)-related neuropathology among cognitively normal individuals has been well documented. It has been proposed that these individuals may represent a pre-clinical AD population. Previous studies have demonstrated a negative association between the presence of both amyloid-β (Aβ) plaques and neurofibrillary tangles with ante-mortem cognitive performance, a relationship which is likely influenced by a number of factors including age and APOE ɛ4 carrier status. The present study determined whether the presence of neuritic plaques (NPs) and diffuse plaques (DPs) are associated with performance in a number of cognitive domains after accounting for APOE ɛ4 carrier status and neurofibrillary tangle presence in a cohort of 123 older participants from the Rush Religious Order Study who died with a premortem clinical diagnosis of no cognitive impairment (NCI). After adjusting for age at death, education, gender, Braak stage, and APOE ɛ4 carrier status, the presence of NPs was associated with lower performance in the cognitive domains of Global Cognition (p = 0.002), Episodic Memory (p = 0.03), Semantic Memory (p = 0.009), and Visuospatial performance (p = 0.006), while DPs showed no association with any cognitive domain examined. These results suggest that decreases in cognition in elderly NCI individuals are associated with an increase in NPs and not DPs when age at death, education, gender, APOE ɛ4 status, and Braak stage are taken into consideration.

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  • Authors+Show Affiliations

    ,

    Banner Alzheimer's Institute, Phoenix, AZ, USA.

    ,

    Department of Neurobiology, Barrow Neurological Institute, Phoenix, AZ, USA.

    ,

    Banner Alzheimer's Institute, Phoenix, AZ, USA.

    Department of Neurobiology, Barrow Neurological Institute, Phoenix, AZ, USA. Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.

    Source

    Journal of Alzheimer's disease : JAD 53:4 2016 07 14 pg 1641-52

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Apolipoprotein E4
    Autopsy
    Brain
    Cognition Disorders
    Cohort Studies
    Female
    Humans
    Male
    Memory
    Memory, Episodic
    Mental Status Schedule
    Neurofibrillary Tangles
    Neuropsychological Tests
    Plaque, Amyloid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    27540968

    Citation

    Malek-Ahmadi, Michael, et al. "Neuritic and Diffuse Plaque Associations With Memory in Non-Cognitively Impaired Elderly." Journal of Alzheimer's Disease : JAD, vol. 53, no. 4, 2016, pp. 1641-52.
    Malek-Ahmadi M, Perez SE, Chen K, et al. Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly. J Alzheimers Dis. 2016;53(4):1641-52.
    Malek-Ahmadi, M., Perez, S. E., Chen, K., & Mufson, E. J. (2016). Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly. Journal of Alzheimer's Disease : JAD, 53(4), pp. 1641-52. doi:10.3233/JAD-160365.
    Malek-Ahmadi M, et al. Neuritic and Diffuse Plaque Associations With Memory in Non-Cognitively Impaired Elderly. J Alzheimers Dis. 2016 07 14;53(4):1641-52. PubMed PMID: 27540968.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly. AU - Malek-Ahmadi,Michael, AU - Perez,Sylvia E, AU - Chen,Kewei, AU - Mufson,Elliott J, PY - 2016/8/20/entrez PY - 2016/8/20/pubmed PY - 2018/1/30/medline KW - Amyloid-β KW - Braak stage KW - cognition KW - neuropathology KW - pre-clinical Alzheimer’s disease SP - 1641 EP - 52 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 53 IS - 4 N2 - The presence of Alzheimer's disease (AD)-related neuropathology among cognitively normal individuals has been well documented. It has been proposed that these individuals may represent a pre-clinical AD population. Previous studies have demonstrated a negative association between the presence of both amyloid-β (Aβ) plaques and neurofibrillary tangles with ante-mortem cognitive performance, a relationship which is likely influenced by a number of factors including age and APOE ɛ4 carrier status. The present study determined whether the presence of neuritic plaques (NPs) and diffuse plaques (DPs) are associated with performance in a number of cognitive domains after accounting for APOE ɛ4 carrier status and neurofibrillary tangle presence in a cohort of 123 older participants from the Rush Religious Order Study who died with a premortem clinical diagnosis of no cognitive impairment (NCI). After adjusting for age at death, education, gender, Braak stage, and APOE ɛ4 carrier status, the presence of NPs was associated with lower performance in the cognitive domains of Global Cognition (p = 0.002), Episodic Memory (p = 0.03), Semantic Memory (p = 0.009), and Visuospatial performance (p = 0.006), while DPs showed no association with any cognitive domain examined. These results suggest that decreases in cognition in elderly NCI individuals are associated with an increase in NPs and not DPs when age at death, education, gender, APOE ɛ4 status, and Braak stage are taken into consideration. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/27540968/Neuritic_and_Diffuse_Plaque_Associations_with_Memory_in_Non_Cognitively_Impaired_Elderly_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-160365 DB - PRIME DP - Unbound Medicine ER -