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Differential association of left and right hippocampal volumes with verbal episodic and spatial memory in older adults.
Neuropsychologia 2016; 93(Pt B):380-385N

Abstract

The hippocampus plays a critical role in verbal and spatial memory, thus any pathological damage to this formation may lead to cognitive impairment. It is suggested that right and left hippocampi are affected differentially in healthy or pathologic aging. The purpose of this study was to test the hypothesis that verbal episodic memory performance is associated with left hippocampal volume (HV) while spatial memory is associated with right HV. 115 non-demented adults over age 70 were drawn from the Einstein Aging Study. Verbal memory was measured using the free recall score from the Free and Cued Selective Reminding Test - immediate recall (FCSRT-IR), logical memory immediate and delayed subtests (LM-I and LM-II) from the Wechsler Memory Scale-Revised (WMS-R). Spatial Memory was measured using a computerized dot memory paradigm that has been validated for use in older adults. All participants underwent 3T MRI with subsequent automatized measurement of the volume of each hippocampus. The sample had a mean age of 78.7 years (SD=5.0); 57% were women, and 52% were white. Participants had a mean of 14.3 years (SD=3.5) of education. In regression models, two tests of verbal memory (FCSRT-IR free recall and LM-II) were positively associated with left HV, but not with right HV. Performance on the spatial memory task was associated with right HV, but not left HV. Our findings support the hypothesis that the left hippocampus plays a critical role in episodic verbal memory, while right hippocampus might be more important for spatial memory processing among non-demented older adults.

Authors+Show Affiliations

Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology, Montefiore Medical Center, Bronx, NY 10467, USA. Electronic address: aezzati@einstein.yu.edu.Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.The Gruss Magnetic Resonance Research Center and Departments of Radiology, Psychiatry and Behavioral Sciences and the Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Radiology, Montefiore Medical Center, Bronx, NY 10467, USA.Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Psychology, Fordham University, Bronx, NY 10604, USA.Department of Human Development and Family Studies, Pennsylvania State University, University Park, PA, USA.Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology, Montefiore Medical Center, Bronx, NY 10467, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27542320

Citation

Ezzati, Ali, et al. "Differential Association of Left and Right Hippocampal Volumes With Verbal Episodic and Spatial Memory in Older Adults." Neuropsychologia, vol. 93, no. Pt B, 2016, pp. 380-385.
Ezzati A, Katz MJ, Zammit AR, et al. Differential association of left and right hippocampal volumes with verbal episodic and spatial memory in older adults. Neuropsychologia. 2016;93(Pt B):380-385.
Ezzati, A., Katz, M. J., Zammit, A. R., Lipton, M. L., Zimmerman, M. E., Sliwinski, M. J., & Lipton, R. B. (2016). Differential association of left and right hippocampal volumes with verbal episodic and spatial memory in older adults. Neuropsychologia, 93(Pt B), pp. 380-385. doi:10.1016/j.neuropsychologia.2016.08.016.
Ezzati A, et al. Differential Association of Left and Right Hippocampal Volumes With Verbal Episodic and Spatial Memory in Older Adults. Neuropsychologia. 2016;93(Pt B):380-385. PubMed PMID: 27542320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential association of left and right hippocampal volumes with verbal episodic and spatial memory in older adults. AU - Ezzati,Ali, AU - Katz,Mindy J, AU - Zammit,Andrea R, AU - Lipton,Michael L, AU - Zimmerman,Molly E, AU - Sliwinski,Martin J, AU - Lipton,Richard B, Y1 - 2016/08/16/ PY - 2015/12/18/received PY - 2016/06/28/revised PY - 2016/08/14/accepted PY - 2016/8/21/pubmed PY - 2017/5/10/medline PY - 2016/8/21/entrez KW - Hippocampus KW - Older adults KW - Spatial memory KW - Verbal episodic memory SP - 380 EP - 385 JF - Neuropsychologia JO - Neuropsychologia VL - 93 IS - Pt B N2 - The hippocampus plays a critical role in verbal and spatial memory, thus any pathological damage to this formation may lead to cognitive impairment. It is suggested that right and left hippocampi are affected differentially in healthy or pathologic aging. The purpose of this study was to test the hypothesis that verbal episodic memory performance is associated with left hippocampal volume (HV) while spatial memory is associated with right HV. 115 non-demented adults over age 70 were drawn from the Einstein Aging Study. Verbal memory was measured using the free recall score from the Free and Cued Selective Reminding Test - immediate recall (FCSRT-IR), logical memory immediate and delayed subtests (LM-I and LM-II) from the Wechsler Memory Scale-Revised (WMS-R). Spatial Memory was measured using a computerized dot memory paradigm that has been validated for use in older adults. All participants underwent 3T MRI with subsequent automatized measurement of the volume of each hippocampus. The sample had a mean age of 78.7 years (SD=5.0); 57% were women, and 52% were white. Participants had a mean of 14.3 years (SD=3.5) of education. In regression models, two tests of verbal memory (FCSRT-IR free recall and LM-II) were positively associated with left HV, but not with right HV. Performance on the spatial memory task was associated with right HV, but not left HV. Our findings support the hypothesis that the left hippocampus plays a critical role in episodic verbal memory, while right hippocampus might be more important for spatial memory processing among non-demented older adults. SN - 1873-3514 UR - https://www.unboundmedicine.com/medline/citation/27542320/Differential_association_of_left_and_right_hippocampal_volumes_with_verbal_episodic_and_spatial_memory_in_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(16)30307-4 DB - PRIME DP - Unbound Medicine ER -