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Surgical pleth index: prediction of postoperative pain and influence of arousal.
Br J Anaesth 2016; 117(3):371-4BJ

Abstract

BACKGROUND

There are conflicting reports concerning the outcome after anaesthesia guided by the surgical pleth index (SPI; GE Healthcare, Helsinki, Finland). One potential explanation may be the lack of evidence for the selection of SPI cut-off values. The aim of this trial was to investigate the correlation between SPI, arousal, and postoperative pain and to define a cut-off value for SPI to predict moderate-to-severe pain.

METHODS

After obtaining ethical approval and written informed consent, 70 patients undergoing non-emergency surgery were enrolled. Data relating to SPI, heart rate, mean arterial pressure, and state entropy were recorded every 10 s for the last 10 min of surgery (state entropy <60 at all times). Subsequently, recordings continued during the phase of arousal. After recovery room admission, pain scores (numerical rating scale 0-10) were obtained every 3 min for 15 min.

RESULTS

Data from 65 patients were analysed. Receiver-operating characteristic curve analysis revealed an optimal intraoperative cut-off SPI value of 30 to discriminate between numerical rating scale scores 0-3 and 4-10. For this value, the negative and positive predictive values to discriminate between numerical rating scale scores 0-3 and 4-10 were 50 and 89.7%, respectively. The SPI was significantly affected by arousal, and SPI scores obtained during this phase were not predictive of postoperative pain.

CONCLUSIONS

Surgical pleth index values are predictive of postoperative pain only if obtained before patient arousal. In contrast to previous studies, a relatively low SPI, >30, appears to predict pain with a high positive predictive value and may therefore be suggested for future studies of SPI-guided anaesthesia.

CLINICAL TRIAL REGISTRATION

Australian New Zealand Clinical Trials Registry: ACTRN12615000804583.

Authors+Show Affiliations

School of Medicine and Pharmacology, University of Western Australia, Level 2 Royal Perth Hospital MRF Building, Rear 50 Murray Street, Perth, WA 6000, Australia Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, Perth, WA, Australia.Faculty of Medicine, Christian-Albrechts-University Kiel, Kiel, Germany.Department of Anaesthesia, Armadale Health Services, Perth, WA, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27543532

Citation

Ledowski, T, et al. "Surgical Pleth Index: Prediction of Postoperative Pain and Influence of Arousal." British Journal of Anaesthesia, vol. 117, no. 3, 2016, pp. 371-4.
Ledowski T, Burke J, Hruby J. Surgical pleth index: prediction of postoperative pain and influence of arousal. Br J Anaesth. 2016;117(3):371-4.
Ledowski, T., Burke, J., & Hruby, J. (2016). Surgical pleth index: prediction of postoperative pain and influence of arousal. British Journal of Anaesthesia, 117(3), pp. 371-4. doi:10.1093/bja/aew226.
Ledowski T, Burke J, Hruby J. Surgical Pleth Index: Prediction of Postoperative Pain and Influence of Arousal. Br J Anaesth. 2016;117(3):371-4. PubMed PMID: 27543532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical pleth index: prediction of postoperative pain and influence of arousal. AU - Ledowski,T, AU - Burke,J, AU - Hruby,J, PY - 2016/05/11/accepted PY - 2016/8/21/entrez PY - 2016/8/21/pubmed PY - 2018/8/2/medline KW - anaesthesia KW - monitoring intraoperative KW - nociception KW - postoperative pain KW - pulse wave analysis SP - 371 EP - 4 JF - British journal of anaesthesia JO - Br J Anaesth VL - 117 IS - 3 N2 - BACKGROUND: There are conflicting reports concerning the outcome after anaesthesia guided by the surgical pleth index (SPI; GE Healthcare, Helsinki, Finland). One potential explanation may be the lack of evidence for the selection of SPI cut-off values. The aim of this trial was to investigate the correlation between SPI, arousal, and postoperative pain and to define a cut-off value for SPI to predict moderate-to-severe pain. METHODS: After obtaining ethical approval and written informed consent, 70 patients undergoing non-emergency surgery were enrolled. Data relating to SPI, heart rate, mean arterial pressure, and state entropy were recorded every 10 s for the last 10 min of surgery (state entropy <60 at all times). Subsequently, recordings continued during the phase of arousal. After recovery room admission, pain scores (numerical rating scale 0-10) were obtained every 3 min for 15 min. RESULTS: Data from 65 patients were analysed. Receiver-operating characteristic curve analysis revealed an optimal intraoperative cut-off SPI value of 30 to discriminate between numerical rating scale scores 0-3 and 4-10. For this value, the negative and positive predictive values to discriminate between numerical rating scale scores 0-3 and 4-10 were 50 and 89.7%, respectively. The SPI was significantly affected by arousal, and SPI scores obtained during this phase were not predictive of postoperative pain. CONCLUSIONS: Surgical pleth index values are predictive of postoperative pain only if obtained before patient arousal. In contrast to previous studies, a relatively low SPI, >30, appears to predict pain with a high positive predictive value and may therefore be suggested for future studies of SPI-guided anaesthesia. CLINICAL TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry: ACTRN12615000804583. SN - 1471-6771 UR - https://www.unboundmedicine.com/medline/citation/27543532/Surgical_pleth_index:_prediction_of_postoperative_pain_and_influence_of_arousal_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0007-0912(17)33798-4 DB - PRIME DP - Unbound Medicine ER -