Tags

Type your tag names separated by a space and hit enter

Influence of regional iron on the motor impairments of Parkinson's disease: A quantitative susceptibility mapping study.
J Magn Reson Imaging. 2017 05; 45(5):1335-1342.JM

Abstract

PURPOSE

Because the roles of striatal-thalamo-cortical and cerebello-thalamo-cortical circuits in the heterogeneous motor impairments of Parkinson's disease (PD) are becoming recognized, this study was designed to investigate the relationships between regional iron in the cardinal subcortical nuclei in these circuits and the different motor impairments.

MATERIALS AND METHODS

Sixty-two PD patients and 40 normal subjects were included and accepted for Enhanced T2 -Star Weighted Angiography Scanning (3.0T). According to the Unified Parkinson's Disease Rating Scale, patients were divided into tremor-dominant (PD-TD) and akinetic/rigid-dominant groups (PD-AR). The intergroup differences of magnetic susceptibility in those cardinal nuclei were measured. Correlation analyses between magnetic susceptibility and motor impairments were performed in all patients.

RESULTS

Nigral magnetic susceptibility significantly increased for each PD group compared with controls (P < 0.001 for PD-TD; P = 0.001 for PD-AR). Magnetic susceptibility in the dentate nucleus (DN) and red nucleus (RN) for the PD-TD patients were significantly increased compared with controls (P < 0.001 and P = 0.004, respectively). Magnetic susceptibility in these regions was also significantly correlated with tremor severity (r = 0.444, P = 0.001 for DN; r = 0.418, P = 0.001 for RN). Significant correlation between caudate magnetic susceptibility and akinetic/rigid severity were observed (r = -0.322, P = 0.015).

CONCLUSION

This study provides evidence that nigral iron accumulation is a common characteristic in PD, while iron accumulation in the DN and RN is correlated with tremor symptoms. Our data also indicate that caudate iron content may be a potential marker for akinetic/rigid progression.

LEVEL OF EVIDENCE

3 J. MAGN. RESON. IMAGING 2017;45:1335-1342.

Authors+Show Affiliations

Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, North Carolina, USA.Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27545971

Citation

Guan, Xiaojun, et al. "Influence of Regional Iron On the Motor Impairments of Parkinson's Disease: a Quantitative Susceptibility Mapping Study." Journal of Magnetic Resonance Imaging : JMRI, vol. 45, no. 5, 2017, pp. 1335-1342.
Guan X, Xuan M, Gu Q, et al. Influence of regional iron on the motor impairments of Parkinson's disease: A quantitative susceptibility mapping study. J Magn Reson Imaging. 2017;45(5):1335-1342.
Guan, X., Xuan, M., Gu, Q., Xu, X., Huang, P., Wang, N., Shen, Z., Xu, J., Luo, W., & Zhang, M. (2017). Influence of regional iron on the motor impairments of Parkinson's disease: A quantitative susceptibility mapping study. Journal of Magnetic Resonance Imaging : JMRI, 45(5), 1335-1342. https://doi.org/10.1002/jmri.25434
Guan X, et al. Influence of Regional Iron On the Motor Impairments of Parkinson's Disease: a Quantitative Susceptibility Mapping Study. J Magn Reson Imaging. 2017;45(5):1335-1342. PubMed PMID: 27545971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of regional iron on the motor impairments of Parkinson's disease: A quantitative susceptibility mapping study. AU - Guan,Xiaojun, AU - Xuan,Min, AU - Gu,Quanquan, AU - Xu,Xiaojun, AU - Huang,Peiyu, AU - Wang,Nian, AU - Shen,Zhujing, AU - Xu,Jingjing, AU - Luo,Wei, AU - Zhang,Minming, Y1 - 2016/08/22/ PY - 2016/06/22/received PY - 2016/08/05/accepted PY - 2016/8/23/pubmed PY - 2017/10/24/medline PY - 2016/8/23/entrez KW - Parkinson's disease KW - iron KW - motor impairments KW - quantitative susceptibility mapping SP - 1335 EP - 1342 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 45 IS - 5 N2 - PURPOSE: Because the roles of striatal-thalamo-cortical and cerebello-thalamo-cortical circuits in the heterogeneous motor impairments of Parkinson's disease (PD) are becoming recognized, this study was designed to investigate the relationships between regional iron in the cardinal subcortical nuclei in these circuits and the different motor impairments. MATERIALS AND METHODS: Sixty-two PD patients and 40 normal subjects were included and accepted for Enhanced T2 -Star Weighted Angiography Scanning (3.0T). According to the Unified Parkinson's Disease Rating Scale, patients were divided into tremor-dominant (PD-TD) and akinetic/rigid-dominant groups (PD-AR). The intergroup differences of magnetic susceptibility in those cardinal nuclei were measured. Correlation analyses between magnetic susceptibility and motor impairments were performed in all patients. RESULTS: Nigral magnetic susceptibility significantly increased for each PD group compared with controls (P < 0.001 for PD-TD; P = 0.001 for PD-AR). Magnetic susceptibility in the dentate nucleus (DN) and red nucleus (RN) for the PD-TD patients were significantly increased compared with controls (P < 0.001 and P = 0.004, respectively). Magnetic susceptibility in these regions was also significantly correlated with tremor severity (r = 0.444, P = 0.001 for DN; r = 0.418, P = 0.001 for RN). Significant correlation between caudate magnetic susceptibility and akinetic/rigid severity were observed (r = -0.322, P = 0.015). CONCLUSION: This study provides evidence that nigral iron accumulation is a common characteristic in PD, while iron accumulation in the DN and RN is correlated with tremor symptoms. Our data also indicate that caudate iron content may be a potential marker for akinetic/rigid progression. LEVEL OF EVIDENCE: 3 J. MAGN. RESON. IMAGING 2017;45:1335-1342. SN - 1522-2586 UR - https://www.unboundmedicine.com/medline/citation/27545971/Influence_of_regional_iron_on_the_motor_impairments_of_Parkinson's_disease:_A_quantitative_susceptibility_mapping_study_ L2 - https://doi.org/10.1002/jmri.25434 DB - PRIME DP - Unbound Medicine ER -