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Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans.
J Agric Food Chem 2016; 64(38):7114-20JA

Abstract

Amyloid-β (Aβ)-induced oxidative stress and toxicity are leading risk factors for Alzheimer's disease (AD). Monascin (MS) is a novel compound proposed for antioxidative stress applications and is derived from an edible fungus secondary metabolite. This study assessed the effects of MS on oxidative stress, paralysis, Aβ accumulation, and lifespan in the nematode Caenorhabditis elegans and investigated its underlying mechanisms of action. The results showed that MS increased the survival of C. elegans under juglone-induced oxidative stress and attenuated endogenous levels of reactive oxygen species. Furthermore, MS induced a decline in Aβ-induced paralysis phenotype and Aβ deposits in the transgenic strains CL4176 and CL2006 of C. elegans, which expresses human muscle-specific Aβ1-42 in the cytoplasm of body wall muscle cells. In addition, mRNA levels of strain CL4176 of several antioxidant genes (sod-1, sod-2, sod-3, hsp16.2) and daf-16 were up-regulated by MS treatment when compared to the nontreated controls. Further evidence showed that MS treatment in C. elegans strains lacking DAF-16/FOXO did not affect paralysis or lifespan phenotypes. The findings indicate that MS reduces oxidative stress and Aβ toxicity via DAF-16 in C. elegans, suggesting that MS can be used for the prevention of AD-associated oxidative stress complications.

Authors+Show Affiliations

Department of Bioenvironmental Systems Engineering and ‡Department of Biochemical Science and Technology, National Taiwan University , No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan.Department of Bioenvironmental Systems Engineering and ‡Department of Biochemical Science and Technology, National Taiwan University , No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan.Department of Bioenvironmental Systems Engineering and ‡Department of Biochemical Science and Technology, National Taiwan University , No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27554775

Citation

Shi, Yeu-Ching, et al. "Monascin From Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity Via DAF-16/FOXO in Caenorhabditis Elegans." Journal of Agricultural and Food Chemistry, vol. 64, no. 38, 2016, pp. 7114-20.
Shi YC, Pan TM, Liao VH. Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans. J Agric Food Chem. 2016;64(38):7114-20.
Shi, Y. C., Pan, T. M., & Liao, V. H. (2016). Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry, 64(38), pp. 7114-20. doi:10.1021/acs.jafc.6b02779.
Shi YC, Pan TM, Liao VH. Monascin From Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity Via DAF-16/FOXO in Caenorhabditis Elegans. J Agric Food Chem. 2016 Sep 28;64(38):7114-20. PubMed PMID: 27554775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans. AU - Shi,Yeu-Ching, AU - Pan,Tzu-Ming, AU - Liao,Vivian Hsiu-Chuan, Y1 - 2016/09/14/ PY - 2016/8/25/entrez PY - 2016/8/25/pubmed PY - 2017/4/27/medline KW - Alzheimer’s disease (AD) KW - Caenorhabditis elegans KW - DAF-16 KW - amyloid-β KW - fungus secondary metabolite KW - monascin KW - oxidative stress SP - 7114 EP - 20 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 64 IS - 38 N2 - Amyloid-β (Aβ)-induced oxidative stress and toxicity are leading risk factors for Alzheimer's disease (AD). Monascin (MS) is a novel compound proposed for antioxidative stress applications and is derived from an edible fungus secondary metabolite. This study assessed the effects of MS on oxidative stress, paralysis, Aβ accumulation, and lifespan in the nematode Caenorhabditis elegans and investigated its underlying mechanisms of action. The results showed that MS increased the survival of C. elegans under juglone-induced oxidative stress and attenuated endogenous levels of reactive oxygen species. Furthermore, MS induced a decline in Aβ-induced paralysis phenotype and Aβ deposits in the transgenic strains CL4176 and CL2006 of C. elegans, which expresses human muscle-specific Aβ1-42 in the cytoplasm of body wall muscle cells. In addition, mRNA levels of strain CL4176 of several antioxidant genes (sod-1, sod-2, sod-3, hsp16.2) and daf-16 were up-regulated by MS treatment when compared to the nontreated controls. Further evidence showed that MS treatment in C. elegans strains lacking DAF-16/FOXO did not affect paralysis or lifespan phenotypes. The findings indicate that MS reduces oxidative stress and Aβ toxicity via DAF-16 in C. elegans, suggesting that MS can be used for the prevention of AD-associated oxidative stress complications. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/27554775/Monascin_from_Monascus_Fermented_Products_Reduces_Oxidative_Stress_and_Amyloid_β_Toxicity_via_DAF_16/FOXO_in_Caenorhabditis_elegans_ L2 - https://dx.doi.org/10.1021/acs.jafc.6b02779 DB - PRIME DP - Unbound Medicine ER -