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Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception.
Molecules. 2016 Aug 22; 21(8)M

Abstract

The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produced significant attenuation on the acetic acid-induced abdominal-writhing test. It also produced a significant increase in response latency time in the hot-plate test and a marked reduction in time spent licking the injected paw in both phases of the formalin-induced paw-licking test. In addition, it was also demonstrated that DMFP exhibited significant inhibition of the neurogenic nociceptive response induced by intraplantar injections of capsaicin and glutamate. Moreover, the antinociceptive effect of DMFP in the acetic acid-induced abdominal-writhing test and the hot-plate test was not antagonized by pretreatment with a non-selective opioid receptor antagonist, naloxone. Finally, DMFP did not show any toxic effects and/or mortality in a study of acute toxicity and did not interfere with motor coordination during the Rota-rod test. Our present results show that DMFP exhibits both peripheral and central antinociceptive effects. It was suggested that its peripheral antinociceptive activity is associated with attenuated production and/or release of NO and various pro-inflammatory mediators, while central antinociceptive activity seems to be unrelated to the opioidergic system, but could involve, at least in part, an interaction with the inhibition of capsaicin-sensitive fibers and the glutamatergic system.

Authors+Show Affiliations

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia. nurizzati@cyberauthmed.edu.my.Faculty of Pharmaceutical Sciences, UCSI University, 56000 Cheras, Malaysia. mingtatt7286@gmail.com.Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Malaysia. nordinlajis@gmail.com.Faculty of Industrial Sciences & Technology, University Malaysia Pahang, 26300 Gambang, Malaysia. nadeemupm@gmail.com.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia. ahmadakira@upm.edu.my.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia. enoch@upm.edu.my.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia. daud.israf@gmail.com.Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia. mrs@upm.edu.my.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27556438

Citation

Ismail, Nur Izzati, et al. "Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception." Molecules (Basel, Switzerland), vol. 21, no. 8, 2016.
Ismail NI, Ming-Tatt L, Lajis N, et al. Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception. Molecules. 2016;21(8).
Ismail, N. I., Ming-Tatt, L., Lajis, N., Akhtar, M. N., Akira, A., Perimal, E. K., Israf, D. A., & Sulaiman, M. R. (2016). Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception. Molecules (Basel, Switzerland), 21(8). https://doi.org/10.3390/molecules21081077
Ismail NI, et al. Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception. Molecules. 2016 Aug 22;21(8) PubMed PMID: 27556438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception. AU - Ismail,Nur Izzati, AU - Ming-Tatt,Lee, AU - Lajis,Nordin, AU - Akhtar,Muhammad Nadeem, AU - Akira,Ahmad, AU - Perimal,Enoch Kumar, AU - Israf,Daud Ahmad, AU - Sulaiman,Mohd Roslan, Y1 - 2016/08/22/ PY - 2016/06/28/received PY - 2016/08/11/revised PY - 2016/08/12/accepted PY - 2016/8/25/entrez PY - 2016/8/25/pubmed PY - 2017/4/22/medline KW - 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one KW - TRPV1 receptor KW - antinociceptive activity KW - chalcone KW - glutamatergic system KW - opioidergic system JF - Molecules (Basel, Switzerland) JO - Molecules VL - 21 IS - 8 N2 - The antinociceptive effects produced by intraperitoneal administration of a novel synthetic chalcone, 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMFP), were investigated in several mouse models of induced nociception. The administration of DMFP (0.1, 0.5, 1.0 and 5.0 mg/kg) produced significant attenuation on the acetic acid-induced abdominal-writhing test. It also produced a significant increase in response latency time in the hot-plate test and a marked reduction in time spent licking the injected paw in both phases of the formalin-induced paw-licking test. In addition, it was also demonstrated that DMFP exhibited significant inhibition of the neurogenic nociceptive response induced by intraplantar injections of capsaicin and glutamate. Moreover, the antinociceptive effect of DMFP in the acetic acid-induced abdominal-writhing test and the hot-plate test was not antagonized by pretreatment with a non-selective opioid receptor antagonist, naloxone. Finally, DMFP did not show any toxic effects and/or mortality in a study of acute toxicity and did not interfere with motor coordination during the Rota-rod test. Our present results show that DMFP exhibits both peripheral and central antinociceptive effects. It was suggested that its peripheral antinociceptive activity is associated with attenuated production and/or release of NO and various pro-inflammatory mediators, while central antinociceptive activity seems to be unrelated to the opioidergic system, but could involve, at least in part, an interaction with the inhibition of capsaicin-sensitive fibers and the glutamatergic system. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/27556438/Antinociceptive_Effect_of_3__23_Dimethoxyphenyl__1__5_methylfuran_2_yl_prop_2_en_1_one_in_Mice_Models_of_Induced_Nociception_ L2 - https://www.mdpi.com/resolver?pii=molecules21081077 DB - PRIME DP - Unbound Medicine ER -