Tags

Type your tag names separated by a space and hit enter

Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study.
Age (Dordr). 2016 Dec; 38(5-6):505-512.A

Abstract

Older individuals who exercise regularly exhibit greater resistance to oxidative stress than their sedentary peers, suggesting that exercise can modify age-associated loss of resistance to oxidative stress. However, we recently demonstrated that a single bout of exercise confers protection against a subsequent oxidative challenge in young, but not older adults. We therefore hypothesized that repeated bouts of exercise would be needed to increase resistance to an oxidative challenge in sedentary older middle-aged adults. Sedentary older middle-aged men and women (50-63 years, n = 11) participated in an 8-week exercise intervention. Maximal oxygen consumption was measured before and after the intervention. The exercise intervention consisted of three sessions per week, for 45 min at an intensity corresponding to 70-85 % maximal heart rate (HRmax). Resistance to oxidative stress was measured by F2-isoprostane response to a forearm ischemia/reperfusion (I/R) trial. Each participant underwent the I/R trial before and after the exercise intervention. The intervention elicited a significant increase in maximal oxygen consumption (VO2max) (P < 0.0001). Baseline levels of F2-isoprostanes pre- and post-intervention did not differ, but the F2-isoprostane response to the I/R trial was significantly lower following the exercise intervention (time-by-trial interaction, P = 0.043). Individual improvements in aerobic fitness were associated with greater improvements in the F2-isoprostane response (r = -0.761, P = 0.011), further supporting the role of aerobic fitness in resistance to oxidative stress. These data demonstrate that regular exercise with improved fitness leads to increased resistance to oxidative stress in older middle-aged adults and that this measure is modifiable in previously sedentary individuals.

Authors+Show Affiliations

Department of Biological Sciences, Northern Arizona University, PO Box 5640, Flagstaff, AZ, 86011-5640, USA.Department of Biological Sciences, Northern Arizona University, PO Box 5640, Flagstaff, AZ, 86011-5640, USA. tinna.traustadottir@nau.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27558118

Citation

Done, Aaron J., and Tinna Traustadóttir. "Aerobic Exercise Increases Resistance to Oxidative Stress in Sedentary Older Middle-aged Adults. a Pilot Study." Age (Dordrecht, Netherlands), vol. 38, no. 5-6, 2016, pp. 505-512.
Done AJ, Traustadóttir T. Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study. Age (Dordr). 2016;38(5-6):505-512.
Done, A. J., & Traustadóttir, T. (2016). Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study. Age (Dordrecht, Netherlands), 38(5-6), 505-512. https://doi.org/10.1007/s11357-016-9942-x
Done AJ, Traustadóttir T. Aerobic Exercise Increases Resistance to Oxidative Stress in Sedentary Older Middle-aged Adults. a Pilot Study. Age (Dordr). 2016;38(5-6):505-512. PubMed PMID: 27558118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study. AU - Done,Aaron J, AU - Traustadóttir,Tinna, Y1 - 2016/08/25/ PY - 2016/03/02/received PY - 2016/07/29/accepted PY - 2016/8/26/pubmed PY - 2017/12/19/medline PY - 2016/8/26/entrez KW - Aging KW - F2-isoprostanes KW - Ischemia-reperfusion KW - Redox balance SP - 505 EP - 512 JF - Age (Dordrecht, Netherlands) JO - Age (Dordr) VL - 38 IS - 5-6 N2 - Older individuals who exercise regularly exhibit greater resistance to oxidative stress than their sedentary peers, suggesting that exercise can modify age-associated loss of resistance to oxidative stress. However, we recently demonstrated that a single bout of exercise confers protection against a subsequent oxidative challenge in young, but not older adults. We therefore hypothesized that repeated bouts of exercise would be needed to increase resistance to an oxidative challenge in sedentary older middle-aged adults. Sedentary older middle-aged men and women (50-63 years, n = 11) participated in an 8-week exercise intervention. Maximal oxygen consumption was measured before and after the intervention. The exercise intervention consisted of three sessions per week, for 45 min at an intensity corresponding to 70-85 % maximal heart rate (HRmax). Resistance to oxidative stress was measured by F2-isoprostane response to a forearm ischemia/reperfusion (I/R) trial. Each participant underwent the I/R trial before and after the exercise intervention. The intervention elicited a significant increase in maximal oxygen consumption (VO2max) (P < 0.0001). Baseline levels of F2-isoprostanes pre- and post-intervention did not differ, but the F2-isoprostane response to the I/R trial was significantly lower following the exercise intervention (time-by-trial interaction, P = 0.043). Individual improvements in aerobic fitness were associated with greater improvements in the F2-isoprostane response (r = -0.761, P = 0.011), further supporting the role of aerobic fitness in resistance to oxidative stress. These data demonstrate that regular exercise with improved fitness leads to increased resistance to oxidative stress in older middle-aged adults and that this measure is modifiable in previously sedentary individuals. SN - 1574-4647 UR - https://www.unboundmedicine.com/medline/citation/27558118/Aerobic_exercise_increases_resistance_to_oxidative_stress_in_sedentary_older_middle_aged_adults__A_pilot_study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27558118/ DB - PRIME DP - Unbound Medicine ER -