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Urethral inflammatory response to ureaplasma is significantly lower than to Mycoplasma genitalium and Chlamydia trachomatis.
Int J STD AIDS 2017; 28(8):773-780IJ

Abstract

A non-syndromic approach to treatment of people with non-gonococcal urethritis (NGU) requires identification of pathogens and understanding of the role of those pathogens in causing disease. The most commonly detected and isolated micro-organisms in the male urethral tract are bacteria belonging to the family of Mycoplasmataceae, in particular Ureaplasma urealyticum and Ureaplasma parvum. To better understand the role of these Ureaplasma species in NGU, we have performed a prospective analysis of male patients voluntarily attending a drop in STI clinic in Oslo. Of 362 male patients who were tested for NGU using microscopy of urethral smears, we found the following sexually transmissible micro-organisms: 16% Chlamydia trachomatis, 5% Mycoplasma genitalium, 14% U. urealyticum, 14% U. parvum and 5% Mycoplasma hominis. We found a high concordance in detecting in turn U. urealyticum and U. parvum using 16s rRNA gene and ureD gene as targets for nucleic acid amplification testing (NAAT). Whilst there was a strong association between microscopic signs of NGU and C. trachomatis infection, association of M. genitalium and U. urealyticum infections in turn were found only in patients with severe NGU (>30 polymorphonuclear leucocytes, PMNL/high powered fields, HPF). U. parvum was found to colonise a high percentage of patients with no or mild signs of NGU (0-9 PMNL/HPF). We conclude that urethral inflammatory response to ureaplasmas is less severe than to C. trachomatis and M. genitalium in most patients and that testing and treatment of ureaplasma-positive patients should only be considered when other STIs have been ruled out.

Authors+Show Affiliations

1 The Olafia Clinic, Faculty of Medicine, Oslo University Hospital, Oslo, Norway.2 Fürst Medisinsk Laboratorium, Oslo, Norway.1 The Olafia Clinic, Faculty of Medicine, Oslo University Hospital, Oslo, Norway.1 The Olafia Clinic, Faculty of Medicine, Oslo University Hospital, Oslo, Norway.1 The Olafia Clinic, Faculty of Medicine, Oslo University Hospital, Oslo, Norway.2 Fürst Medisinsk Laboratorium, Oslo, Norway.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27558163

Citation

Moi, Harald, et al. "Urethral Inflammatory Response to Ureaplasma Is Significantly Lower Than to Mycoplasma Genitalium and Chlamydia Trachomatis." International Journal of STD & AIDS, vol. 28, no. 8, 2017, pp. 773-780.
Moi H, Reinton N, Randjelovic I, et al. Urethral inflammatory response to ureaplasma is significantly lower than to Mycoplasma genitalium and Chlamydia trachomatis. Int J STD AIDS. 2017;28(8):773-780.
Moi, H., Reinton, N., Randjelovic, I., Reponen, E. J., Syvertsen, L., & Moghaddam, A. (2017). Urethral inflammatory response to ureaplasma is significantly lower than to Mycoplasma genitalium and Chlamydia trachomatis. International Journal of STD & AIDS, 28(8), pp. 773-780. doi:10.1177/0956462416666482.
Moi H, et al. Urethral Inflammatory Response to Ureaplasma Is Significantly Lower Than to Mycoplasma Genitalium and Chlamydia Trachomatis. Int J STD AIDS. 2017;28(8):773-780. PubMed PMID: 27558163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urethral inflammatory response to ureaplasma is significantly lower than to Mycoplasma genitalium and Chlamydia trachomatis. AU - Moi,Harald, AU - Reinton,Nils, AU - Randjelovic,Ivana, AU - Reponen,Elina J, AU - Syvertsen,Line, AU - Moghaddam,Amir, Y1 - 2016/08/24/ PY - 2016/8/26/pubmed PY - 2018/1/9/medline PY - 2016/8/26/entrez KW - Chlamydia trachomatis KW - Mycoplasma genitalium KW - Mycoplasma hominis KW - Ureaplasma parvum KW - Ureaplasma urealyticum KW - polymorphonuclear cells KW - urethral smears KW - urethritis SP - 773 EP - 780 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 28 IS - 8 N2 - A non-syndromic approach to treatment of people with non-gonococcal urethritis (NGU) requires identification of pathogens and understanding of the role of those pathogens in causing disease. The most commonly detected and isolated micro-organisms in the male urethral tract are bacteria belonging to the family of Mycoplasmataceae, in particular Ureaplasma urealyticum and Ureaplasma parvum. To better understand the role of these Ureaplasma species in NGU, we have performed a prospective analysis of male patients voluntarily attending a drop in STI clinic in Oslo. Of 362 male patients who were tested for NGU using microscopy of urethral smears, we found the following sexually transmissible micro-organisms: 16% Chlamydia trachomatis, 5% Mycoplasma genitalium, 14% U. urealyticum, 14% U. parvum and 5% Mycoplasma hominis. We found a high concordance in detecting in turn U. urealyticum and U. parvum using 16s rRNA gene and ureD gene as targets for nucleic acid amplification testing (NAAT). Whilst there was a strong association between microscopic signs of NGU and C. trachomatis infection, association of M. genitalium and U. urealyticum infections in turn were found only in patients with severe NGU (>30 polymorphonuclear leucocytes, PMNL/high powered fields, HPF). U. parvum was found to colonise a high percentage of patients with no or mild signs of NGU (0-9 PMNL/HPF). We conclude that urethral inflammatory response to ureaplasmas is less severe than to C. trachomatis and M. genitalium in most patients and that testing and treatment of ureaplasma-positive patients should only be considered when other STIs have been ruled out. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/27558163/Urethral_inflammatory_response_to_ureaplasma_is_significantly_lower_than_to_Mycoplasma_genitalium_and_Chlamydia_trachomatis_ L2 - http://journals.sagepub.com/doi/full/10.1177/0956462416666482?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -