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Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project.
Eur J Cancer Prev 2018; 27(2):124-133EJ

Abstract

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.

Authors+Show Affiliations

Department of Clinical Sciences and Community Health, University of Milan.Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan.Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan.Department of Clinical Sciences and Community Health, University of Milan.Department of Clinical Sciences and Community Health, University of Milan.Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan.Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California.Division of Molecular Medicine.Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.Harbin Medical University, Harbin.Department of Epidemiology and Community Health, University of Ottawa, Ottawa, Ontario.Medical Informatics Center, Peking University, Peking, China.Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - Istituto per lo Studio e la Prevenzione Oncologica (ISPO), Florence.Department of Clinical Sciences and Community Health, University of Milan.The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York.EPIUnit - Institute of Public Health, University of Porto (ISPUP). Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.EPIUnit - Institute of Public Health, University of Porto (ISPUP). Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Medical Epidemiology and Biostatistics.Department of Medical Epidemiology and Biostatistics.Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III. CIBER Epidemiología y Salud Pública (CIBERESP). Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro, Madrid.ISGlobal, Centre for Research in Environmental Epidemiology (CREAL). IMIM (Hospital del Mar Medical Research Institute). Universitat Pompeu Fabra (UPF), Barcelona.ISGlobal, Centre for Research in Environmental Epidemiology (CREAL). Department of Public Health, Miguel Hernandez University, Campus San Juan, Alicante, Spain.ISGlobal, Centre for Research in Environmental Epidemiology (CREAL). Department of Public Health, Miguel Hernandez University, Campus San Juan, Alicante, Spain.Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Canada. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds.Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Community Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo.Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario 'Agostino Gemelli'.Department of Medicine, Memorial Sloan Kettering Cancer Centre.Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.Department of Public Health and Community Health, School of Health Professions, Athens Technological Educational Institute.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York.Section of Hygiene - Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario 'Agostino Gemelli'. ICAHN School of Medicine at Mount Sinai, New York, USA. IRCCS SAN RAFFAELE PI SANA, Rome, Italy.Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan.Department of Clinical Sciences and Community Health, University of Milan.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27560662

Citation

Praud, Delphine, et al. "Cigarette Smoking and Gastric Cancer in the Stomach Cancer Pooling (StoP) Project." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 27, no. 2, 2018, pp. 124-133.
Praud D, Rota M, Pelucchi C, et al. Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. Eur J Cancer Prev. 2018;27(2):124-133.
Praud, D., Rota, M., Pelucchi, C., Bertuccio, P., Rosso, T., Galeone, C., ... La Vecchia, C. (2018). Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 27(2), pp. 124-133. doi:10.1097/CEJ.0000000000000290.
Praud D, et al. Cigarette Smoking and Gastric Cancer in the Stomach Cancer Pooling (StoP) Project. Eur J Cancer Prev. 2018;27(2):124-133. PubMed PMID: 27560662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. AU - Praud,Delphine, AU - Rota,Matteo, AU - Pelucchi,Claudio, AU - Bertuccio,Paola, AU - Rosso,Tiziana, AU - Galeone,Carlotta, AU - Zhang,Zuo-Feng, AU - Matsuo,Keitaro, AU - Ito,Hidemi, AU - Hu,Jinfu, AU - Johnson,Kenneth C, AU - Yu,Guo-Pei, AU - Palli,Domenico, AU - Ferraroni,Monica, AU - Muscat,Joshua, AU - Lunet,Nuno, AU - Peleteiro,Bárbara, AU - Malekzadeh,Reza, AU - Ye,Weimin, AU - Song,Huan, AU - Zaridze,David, AU - Maximovitch,Dmitry, AU - Aragonés,Nuria, AU - Castaño-Vinyals,Gemma, AU - Vioque,Jesus, AU - Navarrete-Muñoz,Eva M, AU - Pakseresht,Mohammadreza, AU - Pourfarzi,Farhad, AU - Wolk,Alicja, AU - Orsini,Nicola, AU - Bellavia,Andrea, AU - Håkansson,Niclas, AU - Mu,Lina, AU - Pastorino,Roberta, AU - Kurtz,Robert C, AU - Derakhshan,Mohammad H, AU - Lagiou,Areti, AU - Lagiou,Pagona, AU - Boffetta,Paolo, AU - Boccia,Stefania, AU - Negri,Eva, AU - La Vecchia,Carlo, PY - 2016/8/26/pubmed PY - 2019/3/21/medline PY - 2016/8/26/entrez SP - 124 EP - 133 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 27 IS - 2 N2 - Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/27560662/Cigarette_smoking_and_gastric_cancer_in_the_Stomach_Cancer_Pooling__StoP__Project_ L2 - http://Insights.ovid.com/pubmed?pmid=27560662 DB - PRIME DP - Unbound Medicine ER -