Tags

Type your tag names separated by a space and hit enter

Cone Integrity in Glaucoma: An Adaptive-Optics Scanning Laser Ophthalmoscopy Study.
Am J Ophthalmol. 2016 Nov; 171:53-66.AJ

Abstract

PURPOSE

To investigate photoreceptor changes in eyes with glaucoma.

DESIGN

Cross-sectional study.

METHODS

The study included 35 eyes of 35 patients with primary open-angle glaucoma who had suffered parafoveal visual field loss at least 3 years previously, as well as 21 eyes of 21 normal subjects. Eyes with an axial length ≥26.0 mm were excluded. All subjects underwent a full ophthalmologic examination, including spectral-domain optical coherence tomography (SDOCT) and prototype adaptive-optics scanning laser ophthalmoscopy (AO-SLO) imaging.

RESULTS

As determined using AO-SLO, eyes with glaucoma did not differ significantly from normal eyes in terms of either cone density (26 468 ± 3392 cones/m2 vs 26 147 ± 2700 cones/m2, respectively; P = .77; measured 0.5 mm from the foveal center) or cone spatial organization (ratio of hexagonal Voronoi domain: 43.7% ± 4.4% vs 44.3% ± 4.9%; P = .76; measured 0.5 mm from the foveal center). Furthermore, SDOCT showed that the 2 groups did not differ significantly in terms of the photoreceptor-related layer thickness, and that the photoreceptor ellipsoid zone band was continuous in all normal and glaucoma eyes. In glaucoma eyes with vertically asymmetric severity, the more affected side did not significantly differ from the less affected side in terms of cone density, cone spatial organization, or photoreceptor-related layer thickness. In 8 eyes (22.9%) with glaucoma, dark, partition-like areas surrounded the cones on the AO-SLO.

CONCLUSIONS

Both AO-SLO and SDOCT showed cone integrity in eyes with glaucoma, even in areas with visual field and nerve fiber loss. In AO-SLO, microcystic lesions in the inner nuclear layer may influence images of the cone mosaic.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: ohoto@kuhp.kyoto-u.ac.jp.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27565227

Citation

Hasegawa, Tomoko, et al. "Cone Integrity in Glaucoma: an Adaptive-Optics Scanning Laser Ophthalmoscopy Study." American Journal of Ophthalmology, vol. 171, 2016, pp. 53-66.
Hasegawa T, Ooto S, Takayama K, et al. Cone Integrity in Glaucoma: An Adaptive-Optics Scanning Laser Ophthalmoscopy Study. Am J Ophthalmol. 2016;171:53-66.
Hasegawa, T., Ooto, S., Takayama, K., Makiyama, Y., Akagi, T., Ikeda, H. O., Nakanishi, H., Suda, K., Yamada, H., Uji, A., & Yoshimura, N. (2016). Cone Integrity in Glaucoma: An Adaptive-Optics Scanning Laser Ophthalmoscopy Study. American Journal of Ophthalmology, 171, 53-66. https://doi.org/10.1016/j.ajo.2016.08.021
Hasegawa T, et al. Cone Integrity in Glaucoma: an Adaptive-Optics Scanning Laser Ophthalmoscopy Study. Am J Ophthalmol. 2016;171:53-66. PubMed PMID: 27565227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cone Integrity in Glaucoma: An Adaptive-Optics Scanning Laser Ophthalmoscopy Study. AU - Hasegawa,Tomoko, AU - Ooto,Sotaro, AU - Takayama,Kohei, AU - Makiyama,Yukiko, AU - Akagi,Tadamichi, AU - Ikeda,Hanako O, AU - Nakanishi,Hideo, AU - Suda,Kenji, AU - Yamada,Hiroshi, AU - Uji,Akihito, AU - Yoshimura,Nagahisa, Y1 - 2016/08/23/ PY - 2016/03/11/received PY - 2016/08/11/revised PY - 2016/08/12/accepted PY - 2016/8/28/pubmed PY - 2017/5/10/medline PY - 2016/8/28/entrez SP - 53 EP - 66 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 171 N2 - PURPOSE: To investigate photoreceptor changes in eyes with glaucoma. DESIGN: Cross-sectional study. METHODS: The study included 35 eyes of 35 patients with primary open-angle glaucoma who had suffered parafoveal visual field loss at least 3 years previously, as well as 21 eyes of 21 normal subjects. Eyes with an axial length ≥26.0 mm were excluded. All subjects underwent a full ophthalmologic examination, including spectral-domain optical coherence tomography (SDOCT) and prototype adaptive-optics scanning laser ophthalmoscopy (AO-SLO) imaging. RESULTS: As determined using AO-SLO, eyes with glaucoma did not differ significantly from normal eyes in terms of either cone density (26 468 ± 3392 cones/m2 vs 26 147 ± 2700 cones/m2, respectively; P = .77; measured 0.5 mm from the foveal center) or cone spatial organization (ratio of hexagonal Voronoi domain: 43.7% ± 4.4% vs 44.3% ± 4.9%; P = .76; measured 0.5 mm from the foveal center). Furthermore, SDOCT showed that the 2 groups did not differ significantly in terms of the photoreceptor-related layer thickness, and that the photoreceptor ellipsoid zone band was continuous in all normal and glaucoma eyes. In glaucoma eyes with vertically asymmetric severity, the more affected side did not significantly differ from the less affected side in terms of cone density, cone spatial organization, or photoreceptor-related layer thickness. In 8 eyes (22.9%) with glaucoma, dark, partition-like areas surrounded the cones on the AO-SLO. CONCLUSIONS: Both AO-SLO and SDOCT showed cone integrity in eyes with glaucoma, even in areas with visual field and nerve fiber loss. In AO-SLO, microcystic lesions in the inner nuclear layer may influence images of the cone mosaic. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/27565227/Cone_Integrity_in_Glaucoma:_An_Adaptive_Optics_Scanning_Laser_Ophthalmoscopy_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(16)30405-6 DB - PRIME DP - Unbound Medicine ER -