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The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome.

Abstract

BACKGROUND

The impact of metabolic phenotypes on the association of uricemia with urinary albumin/creatinine ratio (uACR) remains unresolved. We evaluated the association between serum uric acid and uACR in persons with 0, and 1-2 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association.

METHODS

Using data from a cross-sectional survey of a representative Czech population aged 25-64 years (n = 3612), we analyzed 1,832 persons without decreased glomerular filtration rate <60ml/min/1.73 m2, diabetes, and MetS. MetS components were defined using the joint statement of the leading societies.

RESULTS

Of the 1,832 selected participants, 64.1% (n = 1174) presented with 1-2 MetS components (age 46.3±11.2; men 51.7%), whereas 35.9% (n = 658) were free of any component (age 39.4±10.0; men 34.2 %). In fully adjusted multiple linear regression models for uricemia, uACR was an independent factor for increase in uric acid levels only in persons with 1-2 MetS components (standardized beta (Sβ) 0.048; P = 0.024); however, not in those without any component (Sβ 0.030; P = 0.264). Uric acid levels increased by the interaction of uACR with VAI (Sβ 0.06; P = 0.012), and of uACR with MAP (Sβ 0.05; P = 0.009). Finally, the association of uACR with uricemia was confined to persons whose VAI together with MAP were ≥the median of 1.35 and 98mm Hg, respectively (Sβ 0.190; P < 0.001).

CONCLUSIONS

We demonstrated a strong modification effect of VAI and MAP on the association between uACR and uricemia, which suggests obesity-related hypertension as the underlying mechanism.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital, Prague, Czech Republic. Montreal University Hospital Research Center, CHUM, Montréal, Canada.

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    Montreal University Hospital Research Center, CHUM, Montréal, Canada.

    ,

    Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital, Prague, Czech Republic. Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

    ,

    Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital, Prague, Czech Republic.

    ,

    Montreal University Hospital Research Center, CHUM, Montréal, Canada.

    ,

    Montreal University Hospital Research Center, CHUM, Montréal, Canada.

    Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University in Prague and Thomayer Hospital, Prague, Czech Republic.

    Source

    American journal of hypertension 29:12 2016 12 01 pg 1335-1342

    MeSH

    Adiposity
    Adult
    Albuminuria
    Biomarkers
    Blood Pressure
    Chi-Square Distribution
    Creatinine
    Cross-Sectional Studies
    Czech Republic
    Female
    Glomerular Filtration Rate
    Humans
    Hypertension
    Hyperuricemia
    Intra-Abdominal Fat
    Kidney
    Linear Models
    Male
    Metabolic Syndrome
    Middle Aged
    Obesity
    Phenotype
    Predictive Value of Tests
    Risk Factors
    Uric Acid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    27565787

    Citation

    Krajcoviechova, Alena, et al. "The Impact of Blood Pressure and Visceral Adiposity On the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome." American Journal of Hypertension, vol. 29, no. 12, 2016, pp. 1335-1342.
    Krajcoviechova A, Tremblay J, Wohlfahrt P, et al. The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome. Am J Hypertens. 2016;29(12):1335-1342.
    Krajcoviechova, A., Tremblay, J., Wohlfahrt, P., Bruthans, J., Tahir, M. R., Hamet, P., & Cifkova, R. (2016). The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome. American Journal of Hypertension, 29(12), pp. 1335-1342. doi:10.1093/ajh/hpw098.
    Krajcoviechova A, et al. The Impact of Blood Pressure and Visceral Adiposity On the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome. Am J Hypertens. 2016 12 1;29(12):1335-1342. PubMed PMID: 27565787.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome. AU - Krajcoviechova,Alena, AU - Tremblay,Johanne, AU - Wohlfahrt,Peter, AU - Bruthans,Jan, AU - Tahir,Muhmmad Ramzan, AU - Hamet,Pavel, AU - Cifkova,Renata, PY - 2016/05/19/received PY - 2016/08/03/accepted PY - 2016/8/28/pubmed PY - 2017/10/24/medline PY - 2016/8/28/entrez KW - albumin/creatinine ratio KW - blood pressure KW - hypertension KW - mean arterial pressure KW - metabolic syndrome KW - uric acid KW - visceral adiposity index. SP - 1335 EP - 1342 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 29 IS - 12 N2 - BACKGROUND: The impact of metabolic phenotypes on the association of uricemia with urinary albumin/creatinine ratio (uACR) remains unresolved. We evaluated the association between serum uric acid and uACR in persons with 0, and 1-2 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association. METHODS: Using data from a cross-sectional survey of a representative Czech population aged 25-64 years (n = 3612), we analyzed 1,832 persons without decreased glomerular filtration rate <60ml/min/1.73 m2, diabetes, and MetS. MetS components were defined using the joint statement of the leading societies. RESULTS: Of the 1,832 selected participants, 64.1% (n = 1174) presented with 1-2 MetS components (age 46.3±11.2; men 51.7%), whereas 35.9% (n = 658) were free of any component (age 39.4±10.0; men 34.2 %). In fully adjusted multiple linear regression models for uricemia, uACR was an independent factor for increase in uric acid levels only in persons with 1-2 MetS components (standardized beta (Sβ) 0.048; P = 0.024); however, not in those without any component (Sβ 0.030; P = 0.264). Uric acid levels increased by the interaction of uACR with VAI (Sβ 0.06; P = 0.012), and of uACR with MAP (Sβ 0.05; P = 0.009). Finally, the association of uACR with uricemia was confined to persons whose VAI together with MAP were ≥the median of 1.35 and 98mm Hg, respectively (Sβ 0.190; P < 0.001). CONCLUSIONS: We demonstrated a strong modification effect of VAI and MAP on the association between uACR and uricemia, which suggests obesity-related hypertension as the underlying mechanism. SN - 1941-7225 UR - https://www.unboundmedicine.com/medline/citation/27565787/The_Impact_of_Blood_Pressure_and_Visceral_Adiposity_on_the_Association_of_Serum_Uric_Acid_With_Albuminuria_in_Adults_Without_Full_Metabolic_Syndrome_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1093/ajh/hpw098 DB - PRIME DP - Unbound Medicine ER -