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Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach.
Curr Cardiol Rep. 2016 10; 18(10):97.CC

Abstract

Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in patients with sustained elevation of blood pressure (BP) ≥150/100 mmHg if possible prior to initiation of antihypertensive therapy, and in patients with resistant hypertension, spontaneous or diuretic-induced hypokalemia, adrenal incidentaloma, obstructive sleep apnea, a family history of early onset of hypertension or cerebrovascular accident <age 40, and first-degree relatives of patients with primary aldosteronism. Clinical and laboratory methods of screening, confirmatory testing, subtype classification, and medical and surgical management are systematically reviewed and illustrated with a clinical case.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, P.O. Box 801414, Charlottesville, VA, 22908-1414, USA. rmc4c@virginia.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27566330

Citation

Carey, Robert M.. "Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach." Current Cardiology Reports, vol. 18, no. 10, 2016, p. 97.
Carey RM. Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach. Curr Cardiol Rep. 2016;18(10):97.
Carey, R. M. (2016). Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach. Current Cardiology Reports, 18(10), 97. https://doi.org/10.1007/s11886-016-0774-1
Carey RM. Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach. Curr Cardiol Rep. 2016;18(10):97. PubMed PMID: 27566330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach. A1 - Carey,Robert M, PY - 2016/8/28/entrez PY - 2016/8/28/pubmed PY - 2017/10/7/medline KW - Aldosterone KW - Hypertension KW - Laparoscopic adrenalectomy KW - Mineralocorticoid receptor antagonist KW - Primary aldosteronism SP - 97 EP - 97 JF - Current cardiology reports JO - Curr Cardiol Rep VL - 18 IS - 10 N2 - Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in patients with sustained elevation of blood pressure (BP) ≥150/100 mmHg if possible prior to initiation of antihypertensive therapy, and in patients with resistant hypertension, spontaneous or diuretic-induced hypokalemia, adrenal incidentaloma, obstructive sleep apnea, a family history of early onset of hypertension or cerebrovascular accident <age 40, and first-degree relatives of patients with primary aldosteronism. Clinical and laboratory methods of screening, confirmatory testing, subtype classification, and medical and surgical management are systematically reviewed and illustrated with a clinical case. SN - 1534-3170 UR - https://www.unboundmedicine.com/medline/citation/27566330/Diagnosing_and_Managing_Primary_Aldosteronism_in_Hypertensive_Patients:_a_Case_Based_Approach_ L2 - https://dx.doi.org/10.1007/s11886-016-0774-1 DB - PRIME DP - Unbound Medicine ER -