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Dietary Salba (Salvia hispanica L.) ameliorates the adipose tissue dysfunction of dyslipemic insulin-resistant rats through mechanisms involving oxidative stress, inflammatory cytokines and peroxisome proliferator-activated receptor γ.
Eur J Nutr. 2018 Feb; 57(1):83-94.EJ

Abstract

PURPOSE

Rats fed a long-term sucrose-rich diet (SRD) developed adipose tissue dysfunction. In the adipose tissue of these SRD-fed rats, the present study analyzed the possible beneficial effects of dietary Salba (chia) seeds in improving or reversing the depletion of antioxidant defenses, changes in pro-inflammatory cytokines and ROS production.

METHODS

Wistar rats were fed a SRD for 3 months. After that, half of the animals continued with the SRD until month 6, while in the other half, corn oil was replaced by chia seeds for 3 months (SRD + chia). A reference group consumed a control diet all the time.

RESULTS

Compared with the SRD-fed rats, the animals fed a SRD + chia showed a reduction in epididymal fat pad weight; the activities of antioxidant enzymes CAT, SOD and GPx returned to control values, while GR significantly improved; mRNA GPx increased, and both mRNA SOD and the redox state of glutathione returned to control values; a significant increase in the expression of Nrf2 was recorded. These results were accompanied by a decrease in XO activity and ROS contents as well as plasma IL-6 and TNF-α levels. Chia seeds reversed the decrease in PPARγ protein mass level and increased the n-3/n-6 fatty acids ratio of membrane phospholipids. Besides, dyslipidemia and insulin sensitivity were normalized.

CONCLUSION

This study provides new information concerning some mechanisms related to the beneficial effects of dietary chia seeds in reversing adipose tissue oxidative stress and improving the adipose tissue dysfunction induced by a SRD.

Authors+Show Affiliations

Departamento de Ciencias Biológicas, Facultad de Bioquímica, Universidad Nacional del Litoral, Ciudad Universitaria El Pozo cc 242, 3000, Santa Fe, Argentina.Laboratorio de Biología Molecular, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Avenida Ejército de los Andes 950, 5700, San Luis, Argentina.Departamento de Ciencias Biológicas, Facultad de Bioquímica, Universidad Nacional del Litoral, Ciudad Universitaria El Pozo cc 242, 3000, Santa Fe, Argentina.Laboratorio de Biología Molecular, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Avenida Ejército de los Andes 950, 5700, San Luis, Argentina.Departamento de Ciencias Biológicas, Facultad de Bioquímica, Universidad Nacional del Litoral, Ciudad Universitaria El Pozo cc 242, 3000, Santa Fe, Argentina. ylombard@fbcb.unl.edu.ar.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27566476

Citation

Ferreira, M R., et al. "Dietary Salba (Salvia Hispanica L.) Ameliorates the Adipose Tissue Dysfunction of Dyslipemic Insulin-resistant Rats Through Mechanisms Involving Oxidative Stress, Inflammatory Cytokines and Peroxisome Proliferator-activated Receptor Γ." European Journal of Nutrition, vol. 57, no. 1, 2018, pp. 83-94.
Ferreira MR, Alvarez SM, Illesca P, et al. Dietary Salba (Salvia hispanica L.) ameliorates the adipose tissue dysfunction of dyslipemic insulin-resistant rats through mechanisms involving oxidative stress, inflammatory cytokines and peroxisome proliferator-activated receptor γ. Eur J Nutr. 2018;57(1):83-94.
Ferreira, M. R., Alvarez, S. M., Illesca, P., Giménez, M. S., & Lombardo, Y. B. (2018). Dietary Salba (Salvia hispanica L.) ameliorates the adipose tissue dysfunction of dyslipemic insulin-resistant rats through mechanisms involving oxidative stress, inflammatory cytokines and peroxisome proliferator-activated receptor γ. European Journal of Nutrition, 57(1), 83-94. https://doi.org/10.1007/s00394-016-1299-5
Ferreira MR, et al. Dietary Salba (Salvia Hispanica L.) Ameliorates the Adipose Tissue Dysfunction of Dyslipemic Insulin-resistant Rats Through Mechanisms Involving Oxidative Stress, Inflammatory Cytokines and Peroxisome Proliferator-activated Receptor Γ. Eur J Nutr. 2018;57(1):83-94. PubMed PMID: 27566476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Salba (Salvia hispanica L.) ameliorates the adipose tissue dysfunction of dyslipemic insulin-resistant rats through mechanisms involving oxidative stress, inflammatory cytokines and peroxisome proliferator-activated receptor γ. AU - Ferreira,M R, AU - Alvarez,S M, AU - Illesca,P, AU - Giménez,M S, AU - Lombardo,Y B, Y1 - 2016/08/26/ PY - 2016/03/08/received PY - 2016/08/13/accepted PY - 2016/8/28/pubmed PY - 2018/8/28/medline PY - 2016/8/28/entrez KW - Adipose tissue KW - Dyslipidemia KW - High-sucrose diet KW - Insulin resistance KW - Oxidative stress KW - α-linolenic acid (ALA) SP - 83 EP - 94 JF - European journal of nutrition JO - Eur J Nutr VL - 57 IS - 1 N2 - PURPOSE: Rats fed a long-term sucrose-rich diet (SRD) developed adipose tissue dysfunction. In the adipose tissue of these SRD-fed rats, the present study analyzed the possible beneficial effects of dietary Salba (chia) seeds in improving or reversing the depletion of antioxidant defenses, changes in pro-inflammatory cytokines and ROS production. METHODS: Wistar rats were fed a SRD for 3 months. After that, half of the animals continued with the SRD until month 6, while in the other half, corn oil was replaced by chia seeds for 3 months (SRD + chia). A reference group consumed a control diet all the time. RESULTS: Compared with the SRD-fed rats, the animals fed a SRD + chia showed a reduction in epididymal fat pad weight; the activities of antioxidant enzymes CAT, SOD and GPx returned to control values, while GR significantly improved; mRNA GPx increased, and both mRNA SOD and the redox state of glutathione returned to control values; a significant increase in the expression of Nrf2 was recorded. These results were accompanied by a decrease in XO activity and ROS contents as well as plasma IL-6 and TNF-α levels. Chia seeds reversed the decrease in PPARγ protein mass level and increased the n-3/n-6 fatty acids ratio of membrane phospholipids. Besides, dyslipidemia and insulin sensitivity were normalized. CONCLUSION: This study provides new information concerning some mechanisms related to the beneficial effects of dietary chia seeds in reversing adipose tissue oxidative stress and improving the adipose tissue dysfunction induced by a SRD. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/27566476/Dietary_Salba__Salvia_hispanica_L___ameliorates_the_adipose_tissue_dysfunction_of_dyslipemic_insulin_resistant_rats_through_mechanisms_involving_oxidative_stress_inflammatory_cytokines_and_peroxisome_proliferator_activated_receptor_γ_ L2 - https://dx.doi.org/10.1007/s00394-016-1299-5 DB - PRIME DP - Unbound Medicine ER -