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Electrochemical composition of the cochlear fluids in the early experimental hydrops. Preliminary results.
Acta Otolaryngol. 1989 May-Jun; 107(5-6):371-4.AO

Abstract

The composition of endolymph and perilymph was studied in the guinea pig cochlea after 2 and 6 weeks of blockage of the vestibular aqueduct in an experimental model of hydrops. Compound action potential was monitored several times in the observation period. The endocochlear potential was measured and the endolymph was sampled at the first and third turns of the scala media. The Na, K, and Cl concentrations were determined in nanolitre aliquots of endolymph and of perilymph, the latter sampled from the basal scala vestibuli. After 2 weeks, no change in endolymphatic electrochemical composition was observed. After 6 weeks, endocochlear potential was decreased by 25% at both cochlear turns; K concentration was decreased in endolymph of the basal turn and Cl concentration was decreased in both turns; the calculated osmolality (Na + K + Cl) was decreased in both turns. These results indicate that the blockage of the vestibular aqueduct induced early auditory dysfunction whereas alterations of the electrochemical composition of endolymph occurred later after a time lag of more than 2 and less than 6 weeks.

Authors+Show Affiliations

INSERM U.251, Département de Physiologie, Faculté Xavier Bichat, Université, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2756827

Citation

Sziklai, I, et al. "Electrochemical Composition of the Cochlear Fluids in the Early Experimental Hydrops. Preliminary Results." Acta Oto-laryngologica, vol. 107, no. 5-6, 1989, pp. 371-4.
Sziklai I, Horner KC, Ferrary E, et al. Electrochemical composition of the cochlear fluids in the early experimental hydrops. Preliminary results. Acta Otolaryngol. 1989;107(5-6):371-4.
Sziklai, I., Horner, K. C., Ferrary, E., Sterkers, O., & Amiel, C. (1989). Electrochemical composition of the cochlear fluids in the early experimental hydrops. Preliminary results. Acta Oto-laryngologica, 107(5-6), 371-4.
Sziklai I, et al. Electrochemical Composition of the Cochlear Fluids in the Early Experimental Hydrops. Preliminary Results. Acta Otolaryngol. 1989 May-Jun;107(5-6):371-4. PubMed PMID: 2756827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical composition of the cochlear fluids in the early experimental hydrops. Preliminary results. AU - Sziklai,I, AU - Horner,K C, AU - Ferrary,E, AU - Sterkers,O, AU - Amiel,C, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 371 EP - 4 JF - Acta oto-laryngologica JO - Acta Otolaryngol. VL - 107 IS - 5-6 N2 - The composition of endolymph and perilymph was studied in the guinea pig cochlea after 2 and 6 weeks of blockage of the vestibular aqueduct in an experimental model of hydrops. Compound action potential was monitored several times in the observation period. The endocochlear potential was measured and the endolymph was sampled at the first and third turns of the scala media. The Na, K, and Cl concentrations were determined in nanolitre aliquots of endolymph and of perilymph, the latter sampled from the basal scala vestibuli. After 2 weeks, no change in endolymphatic electrochemical composition was observed. After 6 weeks, endocochlear potential was decreased by 25% at both cochlear turns; K concentration was decreased in endolymph of the basal turn and Cl concentration was decreased in both turns; the calculated osmolality (Na + K + Cl) was decreased in both turns. These results indicate that the blockage of the vestibular aqueduct induced early auditory dysfunction whereas alterations of the electrochemical composition of endolymph occurred later after a time lag of more than 2 and less than 6 weeks. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/2756827/Electrochemical_composition_of_the_cochlear_fluids_in_the_early_experimental_hydrops__Preliminary_results_ L2 - http://www.tandfonline.com/doi/full/10.3109/00016488909127524 DB - PRIME DP - Unbound Medicine ER -