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A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity.
Obesity (Silver Spring). 2016 09; 24(9):1874-83.O

Abstract

OBJECTIVE

To evaluate the safety and tolerability of alternate-day fasting (ADF) and to compare changes in weight, body composition, lipids, and insulin sensitivity index (Si) with those produced by a standard weight loss diet, moderate daily caloric restriction (CR).

METHODS

Adults with obesity (BMI ≥30 kg/m(2) , age 18-55) were randomized to either zero-calorie ADF (n = 14) or CR (-400 kcal/day, n = 12) for 8 weeks. Outcomes were measured at the end of the 8-week intervention and after 24 weeks of unsupervised follow-up.

RESULTS

No adverse effects were attributed to ADF, and 93% completed the 8-week ADF protocol. At 8 weeks, ADF achieved a 376 kcal/day greater energy deficit; however, there were no significant between-group differences in change in weight (mean ± SE; ADF -8.2 ± 0.9 kg, CR -7.1 ± 1.0 kg), body composition, lipids, or Si. After 24 weeks of unsupervised follow-up, there were no significant differences in weight regain; however, changes from baseline in % fat mass and lean mass were more favorable in ADF.

CONCLUSIONS

ADF is a safe and tolerable approach to weight loss. ADF produced similar changes in weight, body composition, lipids, and Si at 8 weeks and did not appear to increase risk for weight regain 24 weeks after completing the intervention.

Authors+Show Affiliations

Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Department of Biostatistics and Informatics, Colorado School of Public Health, Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.Department of Pediatrics, Children's Hospital Colorado Research Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.Department of Biostatistics and Informatics, Colorado School of Public Health, Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.Department of Community and Behavioral Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.Kaiser Permanente, Denver, Colorado, USA.Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. Department of Neuroscience, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Department of Biostatistics and Informatics, Colorado School of Public Health, Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Department of Medicine, Division of Geriatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Kaiser Permanente, Denver, Colorado, USA.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27569118

Citation

Catenacci, Victoria A., et al. "A Randomized Pilot Study Comparing Zero-calorie Alternate-day Fasting to Daily Caloric Restriction in Adults With Obesity." Obesity (Silver Spring, Md.), vol. 24, no. 9, 2016, pp. 1874-83.
Catenacci VA, Pan Z, Ostendorf D, et al. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring). 2016;24(9):1874-83.
Catenacci, V. A., Pan, Z., Ostendorf, D., Brannon, S., Gozansky, W. S., Mattson, M. P., Martin, B., MacLean, P. S., Melanson, E. L., & Troy Donahoo, W. (2016). A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring, Md.), 24(9), 1874-83. https://doi.org/10.1002/oby.21581
Catenacci VA, et al. A Randomized Pilot Study Comparing Zero-calorie Alternate-day Fasting to Daily Caloric Restriction in Adults With Obesity. Obesity (Silver Spring). 2016;24(9):1874-83. PubMed PMID: 27569118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. AU - Catenacci,Victoria A, AU - Pan,Zhaoxing, AU - Ostendorf,Danielle, AU - Brannon,Sarah, AU - Gozansky,Wendolyn S, AU - Mattson,Mark P, AU - Martin,Bronwen, AU - MacLean,Paul S, AU - Melanson,Edward L, AU - Troy Donahoo,William, PY - 2015/10/07/received PY - 2016/04/01/revised PY - 2016/05/02/accepted PY - 2016/8/30/entrez PY - 2016/8/30/pubmed PY - 2017/6/21/medline SP - 1874 EP - 83 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 24 IS - 9 N2 - OBJECTIVE: To evaluate the safety and tolerability of alternate-day fasting (ADF) and to compare changes in weight, body composition, lipids, and insulin sensitivity index (Si) with those produced by a standard weight loss diet, moderate daily caloric restriction (CR). METHODS: Adults with obesity (BMI ≥30 kg/m(2) , age 18-55) were randomized to either zero-calorie ADF (n = 14) or CR (-400 kcal/day, n = 12) for 8 weeks. Outcomes were measured at the end of the 8-week intervention and after 24 weeks of unsupervised follow-up. RESULTS: No adverse effects were attributed to ADF, and 93% completed the 8-week ADF protocol. At 8 weeks, ADF achieved a 376 kcal/day greater energy deficit; however, there were no significant between-group differences in change in weight (mean ± SE; ADF -8.2 ± 0.9 kg, CR -7.1 ± 1.0 kg), body composition, lipids, or Si. After 24 weeks of unsupervised follow-up, there were no significant differences in weight regain; however, changes from baseline in % fat mass and lean mass were more favorable in ADF. CONCLUSIONS: ADF is a safe and tolerable approach to weight loss. ADF produced similar changes in weight, body composition, lipids, and Si at 8 weeks and did not appear to increase risk for weight regain 24 weeks after completing the intervention. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/27569118/A_randomized_pilot_study_comparing_zero_calorie_alternate_day_fasting_to_daily_caloric_restriction_in_adults_with_obesity_ L2 - https://doi.org/10.1002/oby.21581 DB - PRIME DP - Unbound Medicine ER -