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Rectal Infection With Neisseria gonorrhoeae and Chlamydia trachomatis in Men in the United States.
Clin Infect Dis. 2016 Nov 15; 63(10):1325-1331.CI

Abstract

BACKGROUND

Centers for Disease Control and Prevention guidelines recommend at least annual rectal screening of men who have receptive anal intercourse for Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT). Only limited national data are available on the prevalence of rectal GC and CT infection among US men.

METHODS

In collaboration with a large US commercial laboratory, we estimated positivity of the first rectal GC and CT test ("index" test) in men aged 15-60 years tested between January 2013 and May 2015. We estimated the frequency and positivity of pharyngeal or urine specimens tested for GC and CT on the index date, and the frequency and positivity of repeat rectal testing or any follow-up testing at any anatomic site after the index date.

RESULTS

Of 52 063 tested men aged 15-60 years, approximately 6.1% were positive for GC only, 8.3% for CT only, and 2.7% for both GC and CT on their index date. On that date, 86.5% had either urine or pharyngeal specimens collected, and 56.1% had both specimens collected. Pharyngeal GC infection was highly associated with rectal GC infection. Follow-up testing after 12 months ranged from 42.4% among uninfected men to 56.7% among infected men on the index date. Positivity was at least 5.7% in rectal GC, rectal CT, or pharyngeal GC at their last test.

CONCLUSIONS

This analysis of a large number of male rectal specimens tested for GC and CT suggest that routine testing and timely repeat rectal GC and CT testing should be prioritized among men who report receptive rectal sex.

Authors+Show Affiliations

Division of STD Prevention.Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.Laboratory Corporation of America Holdings, Burlington, North Carolina.Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.Division of STD Prevention.Laboratory Corporation of America Holdings, Burlington, North Carolina.Laboratory Corporation of America Holdings, Burlington, North Carolina.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27572098

Citation

Tao, Guoyu, et al. "Rectal Infection With Neisseria Gonorrhoeae and Chlamydia Trachomatis in Men in the United States." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 63, no. 10, 2016, pp. 1325-1331.
Tao G, Hoover KW, Nye MB, et al. Rectal Infection With Neisseria gonorrhoeae and Chlamydia trachomatis in Men in the United States. Clin Infect Dis. 2016;63(10):1325-1331.
Tao, G., Hoover, K. W., Nye, M. B., Peters, P., Gift, T. L., Peruvemba, R., & Body, B. A. (2016). Rectal Infection With Neisseria gonorrhoeae and Chlamydia trachomatis in Men in the United States. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 63(10), 1325-1331.
Tao G, et al. Rectal Infection With Neisseria Gonorrhoeae and Chlamydia Trachomatis in Men in the United States. Clin Infect Dis. 2016 Nov 15;63(10):1325-1331. PubMed PMID: 27572098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rectal Infection With Neisseria gonorrhoeae and Chlamydia trachomatis in Men in the United States. AU - Tao,Guoyu, AU - Hoover,Karen W, AU - Nye,Melinda B, AU - Peters,Philip, AU - Gift,Thomas L, AU - Peruvemba,Ram, AU - Body,Barbara A, Y1 - 2016/08/29/ PY - 2016/06/21/received PY - 2016/08/10/accepted PY - 2016/10/30/pubmed PY - 2017/10/25/medline PY - 2016/8/31/entrez KW - Chlamydia trachomatis KW - Neisseria gonorrhoeae KW - positivity KW - rectal specimens KW - repeat testing SP - 1325 EP - 1331 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 63 IS - 10 N2 - BACKGROUND: Centers for Disease Control and Prevention guidelines recommend at least annual rectal screening of men who have receptive anal intercourse for Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT). Only limited national data are available on the prevalence of rectal GC and CT infection among US men. METHODS: In collaboration with a large US commercial laboratory, we estimated positivity of the first rectal GC and CT test ("index" test) in men aged 15-60 years tested between January 2013 and May 2015. We estimated the frequency and positivity of pharyngeal or urine specimens tested for GC and CT on the index date, and the frequency and positivity of repeat rectal testing or any follow-up testing at any anatomic site after the index date. RESULTS: Of 52 063 tested men aged 15-60 years, approximately 6.1% were positive for GC only, 8.3% for CT only, and 2.7% for both GC and CT on their index date. On that date, 86.5% had either urine or pharyngeal specimens collected, and 56.1% had both specimens collected. Pharyngeal GC infection was highly associated with rectal GC infection. Follow-up testing after 12 months ranged from 42.4% among uninfected men to 56.7% among infected men on the index date. Positivity was at least 5.7% in rectal GC, rectal CT, or pharyngeal GC at their last test. CONCLUSIONS: This analysis of a large number of male rectal specimens tested for GC and CT suggest that routine testing and timely repeat rectal GC and CT testing should be prioritized among men who report receptive rectal sex. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/27572098/Rectal_Infection_With_Neisseria_gonorrhoeae_and_Chlamydia_trachomatis_in_Men_in_the_United_States_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/ciw594 DB - PRIME DP - Unbound Medicine ER -