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Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome.
Am J Reprod Immunol. 2016 10; 76(4):285-91.AJ

Abstract

PROBLEM

We investigated whether changes in sCD40L, hs-CRP, IL-6, and TNF-α levels are associated with polycystic ovary syndrome (PCOS).

METHOD OF STUDY

Case-control study involving 143 women with and 165 women without PCOS.

RESULT(S)

Reduced sCD40L, and increased hs-CRP and IL-6, but not TNF-α, levels were seen between cases and controls. ROC analysis demonstrated high sensitivity and specificity for sCD40L and hs-CRP as PCOS predictors. Altered sCD40L levels were associated with PCOS, irrespective of body weight. Significant differences in IL-6 levels were seen between non-obese subjects and for TNF-α in obese subjects. sCD40L correlated negatively with age, insulin, HOMA-IR, LH, free testosterone, FAI, and hirsutism, but positively with SHBG. CRP correlated positively with BMI, insulin, HOMA-IR, free testosterone, and hirsutism. IL-6 correlated positively with hirsutism. TNF-α correlated positively with age, but negatively with insulin and HOMA-IR.

CONCLUSION

CD40L, more than IL-6, or TNF-α, constitutes a predictor to explain PCOS and associated features.

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Authors+Show Affiliations

Sarray S
Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain. samehmss@agu.edu.bh.
Almawi WY
Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain.

MeSH

AdultC-Reactive ProteinCD40 LigandCase-Control StudiesDown-RegulationFemaleHumansInflammation MediatorsInterleukin-6ObesityPolycystic Ovary SyndromePrognosisSensitivity and SpecificityTumor Necrosis Factor-alphaUp-Regulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27572328

Citation

Sarray, Sameh, and Wassim Y. Almawi. "Levels of CD40L and Other Inflammatory Biomarkers in Obese and Non-obese Women With Polycystic Ovary Syndrome." American Journal of Reproductive Immunology (New York, N.Y. : 1989), vol. 76, no. 4, 2016, pp. 285-91.
Sarray S, Almawi WY. Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome. Am J Reprod Immunol. 2016;76(4):285-91.
Sarray, S., & Almawi, W. Y. (2016). Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome. American Journal of Reproductive Immunology (New York, N.Y. : 1989), 76(4), 285-91. https://doi.org/10.1111/aji.12549
Sarray S, Almawi WY. Levels of CD40L and Other Inflammatory Biomarkers in Obese and Non-obese Women With Polycystic Ovary Syndrome. Am J Reprod Immunol. 2016;76(4):285-91. PubMed PMID: 27572328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome. AU - Sarray,Sameh, AU - Almawi,Wassim Y, Y1 - 2016/08/29/ PY - 2016/03/10/received PY - 2016/06/21/revised PY - 2016/07/18/accepted PY - 2016/8/31/entrez PY - 2016/8/31/pubmed PY - 2017/12/27/medline KW - CD40L KW - CRP KW - cytokines KW - polycystic ovary syndrome SP - 285 EP - 91 JF - American journal of reproductive immunology (New York, N.Y. : 1989) JO - Am J Reprod Immunol VL - 76 IS - 4 N2 - PROBLEM: We investigated whether changes in sCD40L, hs-CRP, IL-6, and TNF-α levels are associated with polycystic ovary syndrome (PCOS). METHOD OF STUDY: Case-control study involving 143 women with and 165 women without PCOS. RESULT(S): Reduced sCD40L, and increased hs-CRP and IL-6, but not TNF-α, levels were seen between cases and controls. ROC analysis demonstrated high sensitivity and specificity for sCD40L and hs-CRP as PCOS predictors. Altered sCD40L levels were associated with PCOS, irrespective of body weight. Significant differences in IL-6 levels were seen between non-obese subjects and for TNF-α in obese subjects. sCD40L correlated negatively with age, insulin, HOMA-IR, LH, free testosterone, FAI, and hirsutism, but positively with SHBG. CRP correlated positively with BMI, insulin, HOMA-IR, free testosterone, and hirsutism. IL-6 correlated positively with hirsutism. TNF-α correlated positively with age, but negatively with insulin and HOMA-IR. CONCLUSION: CD40L, more than IL-6, or TNF-α, constitutes a predictor to explain PCOS and associated features. SN - 1600-0897 UR - https://www.unboundmedicine.com/medline/citation/27572328/Levels_of_CD40L_and_other_inflammatory_biomarkers_in_obese_and_non_obese_women_with_polycystic_ovary_syndrome_ L2 - https://doi.org/10.1111/aji.12549 DB - PRIME DP - Unbound Medicine ER -