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Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes.
Am J Trop Med Hyg. 2016 Nov 02; 95(5):1169-1173.AJ

Abstract

Previous experimental studies have demonstrated that a number of mosquito-borne flavivirus pathogens are vertically transmitted in their insect vectors, providing a mechanism for these arboviruses to persist during adverse climatic conditions or in the absence of a susceptible vertebrate host. In this study, designed to test whether Zika virus (ZIKV) could be vertically transmitted, female Aedes aegypti and Aedes albopictus were injected with ZIKV, and their F1 adult progeny were tested for ZIKV infection. Six of 69 Ae. aegypti pools, comprised of a total of 1,738 F1 adults, yielded ZIKV upon culture, giving a minimum filial infection rate of 1:290. In contrast, none of 803 F1 Ae. albopictus adults (32 pools) yielded ZIKV. The MFIR for Ae. aegypti was comparable to MFIRs reported for other flaviviruses in mosquitoes, including dengue, Japanese encephalitis, yellow fever, West Nile, and St. Louis encephalitis viruses. The results suggest that vertical transmission may provide a potential mechanism for the virus to survive during adverse conditions.

Authors+Show Affiliations

Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas.Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas.Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas.Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas.Department of Pathology, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27573623

Citation

Thangamani, Saravanan, et al. "Vertical Transmission of Zika Virus in Aedes Aegypti Mosquitoes." The American Journal of Tropical Medicine and Hygiene, vol. 95, no. 5, 2016, pp. 1169-1173.
Thangamani S, Huang J, Hart CE, et al. Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes. Am J Trop Med Hyg. 2016;95(5):1169-1173.
Thangamani, S., Huang, J., Hart, C. E., Guzman, H., & Tesh, R. B. (2016). Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes. The American Journal of Tropical Medicine and Hygiene, 95(5), 1169-1173. https://doi.org/10.4269/ajtmh.16-0448
Thangamani S, et al. Vertical Transmission of Zika Virus in Aedes Aegypti Mosquitoes. Am J Trop Med Hyg. 2016 Nov 2;95(5):1169-1173. PubMed PMID: 27573623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vertical Transmission of Zika Virus in Aedes aegypti Mosquitoes. AU - Thangamani,Saravanan, AU - Huang,Jing, AU - Hart,Charles E, AU - Guzman,Hilda, AU - Tesh,Robert B, Y1 - 2016/08/29/ PY - 2016/06/06/received PY - 2016/08/01/accepted PY - 2016/11/4/pubmed PY - 2017/6/2/medline PY - 2016/8/31/entrez SP - 1169 EP - 1173 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 95 IS - 5 N2 - Previous experimental studies have demonstrated that a number of mosquito-borne flavivirus pathogens are vertically transmitted in their insect vectors, providing a mechanism for these arboviruses to persist during adverse climatic conditions or in the absence of a susceptible vertebrate host. In this study, designed to test whether Zika virus (ZIKV) could be vertically transmitted, female Aedes aegypti and Aedes albopictus were injected with ZIKV, and their F1 adult progeny were tested for ZIKV infection. Six of 69 Ae. aegypti pools, comprised of a total of 1,738 F1 adults, yielded ZIKV upon culture, giving a minimum filial infection rate of 1:290. In contrast, none of 803 F1 Ae. albopictus adults (32 pools) yielded ZIKV. The MFIR for Ae. aegypti was comparable to MFIRs reported for other flaviviruses in mosquitoes, including dengue, Japanese encephalitis, yellow fever, West Nile, and St. Louis encephalitis viruses. The results suggest that vertical transmission may provide a potential mechanism for the virus to survive during adverse conditions. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/27573623/Vertical_Transmission_of_Zika_Virus_in_Aedes_aegypti_Mosquitoes_ L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0448?crawler=true&mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -