Tags

Type your tag names separated by a space and hit enter

Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery.
J Control Release 2017; 265:113-119JC

Abstract

Dissolving microneedles have been employed as a safe and convenient transdermal delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered pyramidal dissolving microneedle patch, composed of silk fibroin tips with the ability of robust mechanical strength, rapid dissolution and drug release supported on a flexible polyvinyl alcohol (PVA) pedestal is reported. To show the utility of this approach the ability of the fabricated microneedles to deliver insulin is demonstrated. The dissolving microneedles have sufficient mechanical strength to be inserted into abdomen skin of mice to a depth of approximately 150μm, and release their encapsulated insulin into the skin to cause a hypoglycemic effect. The fabrication of microneedles avoids high temperature which benefits storage stability at room temperature for 20d. This result indicates >99.4% of insulin remained in the microneedles. In comparison to traditional needle-based administration, the proposed multilayered pyramidal dissolving microneedle patches enable self-administration, miniaturization, pain-free administration, drug delivery and drug stability, all being important features in needle free drug delivery.

Authors+Show Affiliations

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China; Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China. Electronic address: liuran@tsinghua.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27574991

Citation

Lau, Shinying, et al. "Multilayered Pyramidal Dissolving Microneedle Patches With Flexible Pedestals for Improving Effective Drug Delivery." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 265, 2017, pp. 113-119.
Lau S, Fei J, Liu H, et al. Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery. J Control Release. 2017;265:113-119.
Lau, S., Fei, J., Liu, H., Chen, W., & Liu, R. (2017). Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society, 265, pp. 113-119. doi:10.1016/j.jconrel.2016.08.031.
Lau S, et al. Multilayered Pyramidal Dissolving Microneedle Patches With Flexible Pedestals for Improving Effective Drug Delivery. J Control Release. 2017 Nov 10;265:113-119. PubMed PMID: 27574991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery. AU - Lau,Shinying, AU - Fei,Jie, AU - Liu,Haoran, AU - Chen,Weixing, AU - Liu,Ran, Y1 - 2016/08/26/ PY - 2016/06/13/received PY - 2016/08/23/revised PY - 2016/08/25/accepted PY - 2016/8/31/pubmed PY - 2018/11/16/medline PY - 2016/8/31/entrez KW - Flexible KW - Insulin KW - Microneedles KW - Multilayer KW - Pyramidal dissolving KW - Transdermal delivery SP - 113 EP - 119 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 265 N2 - Dissolving microneedles have been employed as a safe and convenient transdermal delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered pyramidal dissolving microneedle patch, composed of silk fibroin tips with the ability of robust mechanical strength, rapid dissolution and drug release supported on a flexible polyvinyl alcohol (PVA) pedestal is reported. To show the utility of this approach the ability of the fabricated microneedles to deliver insulin is demonstrated. The dissolving microneedles have sufficient mechanical strength to be inserted into abdomen skin of mice to a depth of approximately 150μm, and release their encapsulated insulin into the skin to cause a hypoglycemic effect. The fabrication of microneedles avoids high temperature which benefits storage stability at room temperature for 20d. This result indicates >99.4% of insulin remained in the microneedles. In comparison to traditional needle-based administration, the proposed multilayered pyramidal dissolving microneedle patches enable self-administration, miniaturization, pain-free administration, drug delivery and drug stability, all being important features in needle free drug delivery. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/27574991/Multilayered_pyramidal_dissolving_microneedle_patches_with_flexible_pedestals_for_improving_effective_drug_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(16)30601-0 DB - PRIME DP - Unbound Medicine ER -