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Skin barrier in atopic dermatitis: beyond filaggrin.
An Bras Dermatol 2016 Jul-Aug; 91(4):472-8AB

Abstract

Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex.

Authors+Show Affiliations

Universidade de São Paulo (USP) - São Paulo (SP), Brazil.Universidade de São Paulo (USP) - São Paulo (SP), Brazil.Universidade de São Paulo (USP) - São Paulo (SP), Brazil.Universidade de São Paulo (USP) - São Paulo (SP), Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27579743

Citation

Zaniboni, Mariana Colombini, et al. "Skin Barrier in Atopic Dermatitis: Beyond Filaggrin." Anais Brasileiros De Dermatologia, vol. 91, no. 4, 2016, pp. 472-8.
Zaniboni MC, Samorano LP, Orfali RL, et al. Skin barrier in atopic dermatitis: beyond filaggrin. An Bras Dermatol. 2016;91(4):472-8.
Zaniboni, M. C., Samorano, L. P., Orfali, R. L., & Aoki, V. (2016). Skin barrier in atopic dermatitis: beyond filaggrin. Anais Brasileiros De Dermatologia, 91(4), pp. 472-8. doi:10.1590/abd1806-4841.20164412.
Zaniboni MC, et al. Skin Barrier in Atopic Dermatitis: Beyond Filaggrin. An Bras Dermatol. 2016;91(4):472-8. PubMed PMID: 27579743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin barrier in atopic dermatitis: beyond filaggrin. AU - Zaniboni,Mariana Colombini, AU - Samorano,Luciana Paula, AU - Orfali,Raquel Leão, AU - Aoki,Valéria, PY - 2015/01/28/received PY - 2015/05/05/accepted PY - 2016/9/1/entrez PY - 2016/9/1/pubmed PY - 2017/5/4/medline SP - 472 EP - 8 JF - Anais brasileiros de dermatologia JO - An Bras Dermatol VL - 91 IS - 4 N2 - Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex. SN - 1806-4841 UR - https://www.unboundmedicine.com/medline/citation/27579743/Skin_barrier_in_atopic_dermatitis:_beyond_filaggrin_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000400472&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -