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Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Study.
J Neurosci Nurs. 2016 Oct; 48(5):270-3.JN

Abstract

Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune syndrome that presents with personality changes, autonomic dysfunction, and neurologic deterioration. Most patients with this syndrome progress from psychosis to seizure to catatonia, often associated with abnormal movements, autonomic instability, and hypoventilation. First-line treatment constitutes resection of the associated neoplasm, corticosteroids, intravenous immunoglobulin, and plasma exchange. Second-line treatment includes rituximab and cyclophosphamide. A case of confirmed anti-N-methyl-D-aspartate receptor encephalitis is presented that illustrates the diagnostic and treatment challenges associated with this syndrome and underscores the nursing implications of medical management during immunosuppression. This case study recommends surface cooling and a pharmaceutical regimen for management of autonomic storming, which is a hallmark of this disorder.

Authors

No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27579962

Citation

Halbert, Roger Kelsey. "Anti-N-Methyl-D-Aspartate Receptor Encephalitis: a Case Study." The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses, vol. 48, no. 5, 2016, pp. 270-3.
Halbert RK. Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Study. J Neurosci Nurs. 2016;48(5):270-3.
Halbert, R. K. (2016). Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Study. The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses, 48(5), 270-3. https://doi.org/10.1097/JNN.0000000000000232
Halbert RK. Anti-N-Methyl-D-Aspartate Receptor Encephalitis: a Case Study. J Neurosci Nurs. 2016;48(5):270-3. PubMed PMID: 27579962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Study. A1 - Halbert,Roger Kelsey, PY - 2016/9/1/entrez PY - 2016/9/1/pubmed PY - 2017/7/18/medline SP - 270 EP - 3 JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses JO - J Neurosci Nurs VL - 48 IS - 5 N2 - Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune syndrome that presents with personality changes, autonomic dysfunction, and neurologic deterioration. Most patients with this syndrome progress from psychosis to seizure to catatonia, often associated with abnormal movements, autonomic instability, and hypoventilation. First-line treatment constitutes resection of the associated neoplasm, corticosteroids, intravenous immunoglobulin, and plasma exchange. Second-line treatment includes rituximab and cyclophosphamide. A case of confirmed anti-N-methyl-D-aspartate receptor encephalitis is presented that illustrates the diagnostic and treatment challenges associated with this syndrome and underscores the nursing implications of medical management during immunosuppression. This case study recommends surface cooling and a pharmaceutical regimen for management of autonomic storming, which is a hallmark of this disorder. SN - 1945-2810 UR - https://www.unboundmedicine.com/medline/citation/27579962/Anti_N_Methyl_D_Aspartate_Receptor_Encephalitis:_A_Case_Study_ L2 - http://dx.doi.org/10.1097/JNN.0000000000000232 DB - PRIME DP - Unbound Medicine ER -