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Cow's Milk Protein Allergy.
Clin Pediatr (Phila) 2016; 55(11):1054-63CPed

Abstract

Cow's milk protein allergy (CMPA) is a common condition encountered in children with incidence estimated as 2% to 7.5% in the first year of life. Formula and breast-fed babies can present with symptoms of CMPA. It is important to accurately diagnose CMPA to avoid the consequences of either under- or overdiagnosis. CMPA is classically categorized into immunoglobulin E (IgE)- or non-IgE-mediated reaction that vary in clinical manifestations, diagnostic evaluation, and prognosis. The most commonly involved systems in patients with CMPA are gastrointestinal, skin, and respiratory. Evaluation of CMPA starts with good data gathering followed by testing if indicated. Treatment is simply by avoidance of cow's milk protein (CMP) in the child's or mother's diet, if exclusively breast-feeding. This article reviews the definition, epidemiology, risk factors, pathogenesis, clinical presentation, evaluation, management, and prognosis of CMPA and provides an overview of different options for formulas and their indication in the treatment of CMPA.

Authors+Show Affiliations

Children's Hospital of Michigan, Detroit, MI, USA gmousanyazigi@gmail.com.Children's Hospital of Michigan, Detroit, MI, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27582492

Citation

Mousan, Grace, and Deepak Kamat. "Cow's Milk Protein Allergy." Clinical Pediatrics, vol. 55, no. 11, 2016, pp. 1054-63.
Mousan G, Kamat D. Cow's Milk Protein Allergy. Clin Pediatr (Phila). 2016;55(11):1054-63.
Mousan, G., & Kamat, D. (2016). Cow's Milk Protein Allergy. Clinical Pediatrics, 55(11), pp. 1054-63. doi:10.1177/0009922816664512.
Mousan G, Kamat D. Cow's Milk Protein Allergy. Clin Pediatr (Phila). 2016;55(11):1054-63. PubMed PMID: 27582492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cow's Milk Protein Allergy. AU - Mousan,Grace, AU - Kamat,Deepak, Y1 - 2016/08/31/ PY - 2016/9/2/entrez PY - 2016/9/2/pubmed PY - 2017/5/4/medline KW - Allergic colitis KW - allergy KW - amino-acid based formula KW - breast-feeding KW - cow’s milk KW - elimination diet KW - extensively hydrolyzed formula KW - formula feeding KW - oral challenge KW - protein SP - 1054 EP - 63 JF - Clinical pediatrics JO - Clin Pediatr (Phila) VL - 55 IS - 11 N2 - Cow's milk protein allergy (CMPA) is a common condition encountered in children with incidence estimated as 2% to 7.5% in the first year of life. Formula and breast-fed babies can present with symptoms of CMPA. It is important to accurately diagnose CMPA to avoid the consequences of either under- or overdiagnosis. CMPA is classically categorized into immunoglobulin E (IgE)- or non-IgE-mediated reaction that vary in clinical manifestations, diagnostic evaluation, and prognosis. The most commonly involved systems in patients with CMPA are gastrointestinal, skin, and respiratory. Evaluation of CMPA starts with good data gathering followed by testing if indicated. Treatment is simply by avoidance of cow's milk protein (CMP) in the child's or mother's diet, if exclusively breast-feeding. This article reviews the definition, epidemiology, risk factors, pathogenesis, clinical presentation, evaluation, management, and prognosis of CMPA and provides an overview of different options for formulas and their indication in the treatment of CMPA. SN - 1938-2707 UR - https://www.unboundmedicine.com/medline/citation/27582492/Cow's_Milk_Protein_Allergy_ L2 - http://journals.sagepub.com/doi/full/10.1177/0009922816664512?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -