Tags

Type your tag names separated by a space and hit enter

Comparison of relative oxycodone consumption in surgical pleth index-guided analgesia versus conventional analgesia during sevoflurane anesthesia: A randomized controlled trial.
Medicine (Baltimore). 2016 Aug; 95(35):e4743.M

Abstract

BACKGROUND

The surgical pleth index (SPI) is proposed for titration of analgesic drugs during general anesthesia. Several reports have investigated the effect of SPI on the consumption of opioids including remifentanil, fentanyl, and sufentanil during anesthesia, but there are no reports about oxycodone. We aimed to investigate intravenous oxycodone consumption between SPI-guided analgesia and conventional analgesia practices during sevoflurane anesthesia in patients undergoing thyroidectomy.

METHODS

Forty-five patients undergoing elective thyroidectomy were randomly assigned to an SPI group (SPI-guided analgesia group, n = 23) or a control group (conventional analgesia group, n = 22). Anesthesia was maintained with sevoflurane to achieve bispectral index values between 40 and 60. In the SPI group, oxycodone 1 mg was administered intravenously at SPI values over 50; in the control group, oxycodone 1 mg was administered intravenously at the occurrence of tachycardia or hypertension event. Intraoperative oxycodone consumption and extubation time were recorded. The number of hemodynamic and somatic movement events was recorded, as were postoperative pain and recovery scores.

RESULTS

Patients' characteristics were comparable between the groups. Intraoperative oxycodone consumption in the SPI group was significantly lower than the control group (3.5 ± 2.4 vs 5.1 ± 2.4 mg; P = 0.012). Extubation time was significantly shorter in the SPI group (10.6 ± 3.5 vs 13.4 ± 4.6 min; P = 0.026). Hemodynamic and somatic movement events during anesthesia were comparable between the groups, as were numeric rating scales for pain and modified Aldrete scores at postanesthesia care unit.

CONCLUSIONS

SPI-guided analgesia reduces intravenous oxycodone consumption and extubation time compared with conventional analgesia based on clinical parameters during sevoflurane anesthesia in patients undergoing thyroidectomy.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27583920

Citation

Won, Young Ju, et al. "Comparison of Relative Oxycodone Consumption in Surgical Pleth Index-guided Analgesia Versus Conventional Analgesia During Sevoflurane Anesthesia: a Randomized Controlled Trial." Medicine, vol. 95, no. 35, 2016, pp. e4743.
Won YJ, Lim BG, Lee SH, et al. Comparison of relative oxycodone consumption in surgical pleth index-guided analgesia versus conventional analgesia during sevoflurane anesthesia: A randomized controlled trial. Medicine (Baltimore). 2016;95(35):e4743.
Won, Y. J., Lim, B. G., Lee, S. H., Park, S., Kim, H., Lee, I. O., & Kong, M. H. (2016). Comparison of relative oxycodone consumption in surgical pleth index-guided analgesia versus conventional analgesia during sevoflurane anesthesia: A randomized controlled trial. Medicine, 95(35), e4743. https://doi.org/10.1097/MD.0000000000004743
Won YJ, et al. Comparison of Relative Oxycodone Consumption in Surgical Pleth Index-guided Analgesia Versus Conventional Analgesia During Sevoflurane Anesthesia: a Randomized Controlled Trial. Medicine (Baltimore). 2016;95(35):e4743. PubMed PMID: 27583920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of relative oxycodone consumption in surgical pleth index-guided analgesia versus conventional analgesia during sevoflurane anesthesia: A randomized controlled trial. AU - Won,Young Ju, AU - Lim,Byung Gun, AU - Lee,So Hyun, AU - Park,Sangwoo, AU - Kim,Heezoo, AU - Lee,Il Ok, AU - Kong,Myoung Hoon, PY - 2016/9/2/entrez PY - 2016/9/2/pubmed PY - 2017/2/9/medline SP - e4743 EP - e4743 JF - Medicine JO - Medicine (Baltimore) VL - 95 IS - 35 N2 - BACKGROUND: The surgical pleth index (SPI) is proposed for titration of analgesic drugs during general anesthesia. Several reports have investigated the effect of SPI on the consumption of opioids including remifentanil, fentanyl, and sufentanil during anesthesia, but there are no reports about oxycodone. We aimed to investigate intravenous oxycodone consumption between SPI-guided analgesia and conventional analgesia practices during sevoflurane anesthesia in patients undergoing thyroidectomy. METHODS: Forty-five patients undergoing elective thyroidectomy were randomly assigned to an SPI group (SPI-guided analgesia group, n = 23) or a control group (conventional analgesia group, n = 22). Anesthesia was maintained with sevoflurane to achieve bispectral index values between 40 and 60. In the SPI group, oxycodone 1 mg was administered intravenously at SPI values over 50; in the control group, oxycodone 1 mg was administered intravenously at the occurrence of tachycardia or hypertension event. Intraoperative oxycodone consumption and extubation time were recorded. The number of hemodynamic and somatic movement events was recorded, as were postoperative pain and recovery scores. RESULTS: Patients' characteristics were comparable between the groups. Intraoperative oxycodone consumption in the SPI group was significantly lower than the control group (3.5 ± 2.4 vs 5.1 ± 2.4 mg; P = 0.012). Extubation time was significantly shorter in the SPI group (10.6 ± 3.5 vs 13.4 ± 4.6 min; P = 0.026). Hemodynamic and somatic movement events during anesthesia were comparable between the groups, as were numeric rating scales for pain and modified Aldrete scores at postanesthesia care unit. CONCLUSIONS: SPI-guided analgesia reduces intravenous oxycodone consumption and extubation time compared with conventional analgesia based on clinical parameters during sevoflurane anesthesia in patients undergoing thyroidectomy. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/27583920/Comparison_of_relative_oxycodone_consumption_in_surgical_pleth_index_guided_analgesia_versus_conventional_analgesia_during_sevoflurane_anesthesia:_A_randomized_controlled_trial_ L2 - http://dx.doi.org/10.1097/MD.0000000000004743 DB - PRIME DP - Unbound Medicine ER -