Tags

Type your tag names separated by a space and hit enter

Risks of acute coronary syndrome in patients with osteoarthritis: a nationwide population-based cohort study.
Clin Rheumatol. 2016 Nov; 35(11):2807-2813.CR

Abstract

Recent studies have reported that osteoarthritis (OA) is related to inflammation and atherosclerosis. Studies on the relationship between OA and acute coronary syndrome (ACS) are scant. We evaluated the risk of ACS in OA patients of an Asian population. This longitudinal, population-based cohort study investigated the incidence and risk of ACS in 46,042 patients with newly diagnosed OA and 46,042 controls selected randomly from the general population and frequency matched according to age, sex, and entry year (2002-2003). The follow-up period ranged from the entry date until the date of an ACS event, loss to follow-up, or the end of 2010. We employed Cox proportional hazard models to estimate the effects of OA on the risk of ACS. The OA patients showed a 15 % higher risk of ACS than did the controls after adjustment for covariates (adjusted hazard ratio [aHR] = 1.15, 95 % confidence interval [CI] = 1.08-1.23). The risk of ACS in the OA patients was the greatest in young adults (aHR = 2.0, 95 % CI = 1.44-2.78), followed by middle-aged (aHR = 1.15, 95 % CI = 1.01-1.31) and older adults (aHR = 1.11, 95 % CI = 1.03-1.20). The risk of ACS was 1.96-fold in young adults with mild to moderate OA and 3.51-fold in young adults with severe OA compared with their counterparts without OA. OA carries an increased risk of ACS, particularly in young adults with severe OA. Clinicians should employ proactive strategies for preventing ACS occurrence in these patients.

Authors+Show Affiliations

Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, No. 199, Section 1, San-Min Road, Taichung, 40343, Taiwan. chung.w53@msa.hinet.net. Department of Health Services Administration, China Medical University, Taichung, Taiwan. chung.w53@msa.hinet.net. Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan. chung.w53@msa.hinet.net.Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan.Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.Department of Physical Medicine and Rehabilitation, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.Department of Internal Medicine, Lotung Poh-Ai Hospital, Yilan, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27585925

Citation

Chung, Wei-Sheng, et al. "Risks of Acute Coronary Syndrome in Patients With Osteoarthritis: a Nationwide Population-based Cohort Study." Clinical Rheumatology, vol. 35, no. 11, 2016, pp. 2807-2813.
Chung WS, Lin HH, Ho FM, et al. Risks of acute coronary syndrome in patients with osteoarthritis: a nationwide population-based cohort study. Clin Rheumatol. 2016;35(11):2807-2813.
Chung, W. S., Lin, H. H., Ho, F. M., Lai, C. L., & Chao, C. L. (2016). Risks of acute coronary syndrome in patients with osteoarthritis: a nationwide population-based cohort study. Clinical Rheumatology, 35(11), 2807-2813.
Chung WS, et al. Risks of Acute Coronary Syndrome in Patients With Osteoarthritis: a Nationwide Population-based Cohort Study. Clin Rheumatol. 2016;35(11):2807-2813. PubMed PMID: 27585925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risks of acute coronary syndrome in patients with osteoarthritis: a nationwide population-based cohort study. AU - Chung,Wei-Sheng, AU - Lin,Hsuan-Hung, AU - Ho,Feng-Ming, AU - Lai,Chung-Liang, AU - Chao,Chia-Lun, Y1 - 2016/09/01/ PY - 2016/06/05/received PY - 2016/08/19/accepted PY - 2016/08/14/revised PY - 2016/9/3/pubmed PY - 2017/10/14/medline PY - 2016/9/3/entrez KW - Acute coronary syndrome (ACS) KW - Cohort study KW - Inflammation KW - Osteoarthritis (OA) SP - 2807 EP - 2813 JF - Clinical rheumatology JO - Clin Rheumatol VL - 35 IS - 11 N2 - Recent studies have reported that osteoarthritis (OA) is related to inflammation and atherosclerosis. Studies on the relationship between OA and acute coronary syndrome (ACS) are scant. We evaluated the risk of ACS in OA patients of an Asian population. This longitudinal, population-based cohort study investigated the incidence and risk of ACS in 46,042 patients with newly diagnosed OA and 46,042 controls selected randomly from the general population and frequency matched according to age, sex, and entry year (2002-2003). The follow-up period ranged from the entry date until the date of an ACS event, loss to follow-up, or the end of 2010. We employed Cox proportional hazard models to estimate the effects of OA on the risk of ACS. The OA patients showed a 15 % higher risk of ACS than did the controls after adjustment for covariates (adjusted hazard ratio [aHR] = 1.15, 95 % confidence interval [CI] = 1.08-1.23). The risk of ACS in the OA patients was the greatest in young adults (aHR = 2.0, 95 % CI = 1.44-2.78), followed by middle-aged (aHR = 1.15, 95 % CI = 1.01-1.31) and older adults (aHR = 1.11, 95 % CI = 1.03-1.20). The risk of ACS was 1.96-fold in young adults with mild to moderate OA and 3.51-fold in young adults with severe OA compared with their counterparts without OA. OA carries an increased risk of ACS, particularly in young adults with severe OA. Clinicians should employ proactive strategies for preventing ACS occurrence in these patients. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/27585925/Risks_of_acute_coronary_syndrome_in_patients_with_osteoarthritis:_a_nationwide_population_based_cohort_study_ L2 - https://dx.doi.org/10.1007/s10067-016-3391-x DB - PRIME DP - Unbound Medicine ER -