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Prevalence of diabetes mellitus in individuals heterozygous and homozygous for sickle cell anemia.
Clin Physiol Biochem. 1989; 7(2):87-92.CP

Abstract

Colorimetric determinations of glycosylated Hb were carried out in a sample (n = 97) of sickle cell anemia patients, and in an age- and sex-matched group of individuals (n = 45) heterozygous for sickle cell anemia, from the Eastern Province of Saudi Arabia. A statistically significant increase in the value of glycosylated Hb was found in sickle cell trait (HbAS) group, when compared with those of sickle cell anemia (HbSS) and normal (HbAA) groups. Since glycosylated Hb is considered a valid indicator of long-term blood glucose, and assuming normal red blood cell survival in HbAS carriers, the increased value of glycosylated Hb may suggest that there exists a higher incidence of undiagnosed diabetes mellitus in individuals with heterozygous inheritance for sickle cell hemoglobin than homozygous sickle cell patients and normal individuals. The mechanism underlying this observation remains to be defined.

Authors+Show Affiliations

Duke University Marine Biomedical Center, Beaufort, N.C.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2758734

Citation

Alayash, A I., and A al-Quorain. "Prevalence of Diabetes Mellitus in Individuals Heterozygous and Homozygous for Sickle Cell Anemia." Clinical Physiology and Biochemistry, vol. 7, no. 2, 1989, pp. 87-92.
Alayash AI, al-Quorain A. Prevalence of diabetes mellitus in individuals heterozygous and homozygous for sickle cell anemia. Clin Physiol Biochem. 1989;7(2):87-92.
Alayash, A. I., & al-Quorain, A. (1989). Prevalence of diabetes mellitus in individuals heterozygous and homozygous for sickle cell anemia. Clinical Physiology and Biochemistry, 7(2), 87-92.
Alayash AI, al-Quorain A. Prevalence of Diabetes Mellitus in Individuals Heterozygous and Homozygous for Sickle Cell Anemia. Clin Physiol Biochem. 1989;7(2):87-92. PubMed PMID: 2758734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of diabetes mellitus in individuals heterozygous and homozygous for sickle cell anemia. AU - Alayash,A I, AU - al-Quorain,A, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 87 EP - 92 JF - Clinical physiology and biochemistry JO - Clin Physiol Biochem VL - 7 IS - 2 N2 - Colorimetric determinations of glycosylated Hb were carried out in a sample (n = 97) of sickle cell anemia patients, and in an age- and sex-matched group of individuals (n = 45) heterozygous for sickle cell anemia, from the Eastern Province of Saudi Arabia. A statistically significant increase in the value of glycosylated Hb was found in sickle cell trait (HbAS) group, when compared with those of sickle cell anemia (HbSS) and normal (HbAA) groups. Since glycosylated Hb is considered a valid indicator of long-term blood glucose, and assuming normal red blood cell survival in HbAS carriers, the increased value of glycosylated Hb may suggest that there exists a higher incidence of undiagnosed diabetes mellitus in individuals with heterozygous inheritance for sickle cell hemoglobin than homozygous sickle cell patients and normal individuals. The mechanism underlying this observation remains to be defined. SN - 0252-1164 UR - https://www.unboundmedicine.com/medline/citation/2758734/Prevalence_of_diabetes_mellitus_in_individuals_heterozygous_and_homozygous_for_sickle_cell_anemia_ L2 - http://babysfirsttest.org/newborn-screening/conditions/sickle-cell-anemia DB - PRIME DP - Unbound Medicine ER -