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Factors associated with spinal fusion after posterior fossa decompression in pediatric patients with Chiari I malformation and scoliosis.
J Neurosurg Pediatr. 2016 Dec; 25(6):737-743.JN

Abstract

OBJECTIVE

The authors performed a study to identify clinical characteristics of pediatric patients diagnosed with Chiari I malformation and scoliosis associated with a need for spinal fusion after posterior fossa decompression when managing the scoliotic curve.

METHODS

The authors conducted a multicenter retrospective review of 44 patients, aged 18 years or younger, diagnosed with Chiari I malformation and scoliosis who underwent posterior fossa decompression from 2000 to 2010. The outcome of interest was the need for spinal fusion after decompression.

RESULTS

Overall, 18 patients (40%) underwent posterior fossa decompression alone, and 26 patients (60%) required a spinal fusion after the decompression. The mean Cobb angle at presentation and the proportion of patients with curves > 35° differed between the decompression-only and fusion cohorts (30.7° ± 11.8° vs 52.1° ± 26.3°, p = 0.002; 5 of 18 vs 17 of 26, p = 0.031). An odds ratio of 1.0625 favoring a need for fusion was established for each 1° of increase in Cobb angle (p = 0.012, OR 1.0625, 95% CI 1.0135-1.1138). Among the 14 patients older than 10 years of age with a primary Cobb angle exceeding 35°, 13 (93%) ultimately required fusion. Patients with at least 1 year of follow-up whose curves progressed more 10° after decompression were younger than those without curve progression (6.1 ± 3.0 years vs 13.7 ± 3.2 years, p = 0.001, Mann-Whitney U-test). Left apical thoracic curves constituted a higher proportion of curves in the decompression-only group (8 of 16 vs 1 of 21, p = 0.002).

CONCLUSIONS

The need for fusion after posterior fossa decompression reflected the curve severity at clinical presentation. Patients presenting with curves measuring > 35°, as well as those greater than 10 years of age, may be at greater risk for requiring fusion after posterior fossa decompression, while patients less than 10 years of age may require routine monitoring for curve progression. Left apical thoracic curves may have a better response to Chiari malformation decompression.

Authors+Show Affiliations

Department of Neurosurgery, Tufts Medical Center and Floating Hospital for Children, Boston, Massachusetts.Department of Orthopedic Surgery, Children's Hospital of Philadelphia.Department of Neurosurgery, Tufts Medical Center and Floating Hospital for Children, Boston, Massachusetts.Shriners Hospitals for Children-Philadelphia, Pennsylvania.Department of Neurosurgery, Northwestern Medical Center, Chicago, Illinois.Department of Orthopaedic Surgery, Meijo Hospital, Nagoya, Japan.Department of Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.Shriners Hospitals for Children-Philadelphia, Pennsylvania.Institute for Spine and Scoliosis, Lawrenceville, New Jersey; and.Department of Orthopaedic Surgery, IWK Health Center, Halifax, Nova Scotia, Canada.Shriners Hospitals for Children-Philadelphia, Pennsylvania.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27589598

Citation

Mackel, Charles E., et al. "Factors Associated With Spinal Fusion After Posterior Fossa Decompression in Pediatric Patients With Chiari I Malformation and Scoliosis." Journal of Neurosurgery. Pediatrics, vol. 25, no. 6, 2016, pp. 737-743.
Mackel CE, Cahill PJ, Roguski M, et al. Factors associated with spinal fusion after posterior fossa decompression in pediatric patients with Chiari I malformation and scoliosis. J Neurosurg Pediatr. 2016;25(6):737-743.
Mackel, C. E., Cahill, P. J., Roguski, M., Samdani, A. F., Sugrue, P. A., Kawakami, N., Sturm, P. F., Pahys, J. M., Betz, R. R., El-Hawary, R., & Hwang, S. W. (2016). Factors associated with spinal fusion after posterior fossa decompression in pediatric patients with Chiari I malformation and scoliosis. Journal of Neurosurgery. Pediatrics, 25(6), 737-743.
Mackel CE, et al. Factors Associated With Spinal Fusion After Posterior Fossa Decompression in Pediatric Patients With Chiari I Malformation and Scoliosis. J Neurosurg Pediatr. 2016;25(6):737-743. PubMed PMID: 27589598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with spinal fusion after posterior fossa decompression in pediatric patients with Chiari I malformation and scoliosis. AU - Mackel,Charles E, AU - Cahill,Patrick J, AU - Roguski,Marie, AU - Samdani,Amer F, AU - Sugrue,Patrick A, AU - Kawakami,Noriaki, AU - Sturm,Peter F, AU - Pahys,Joshua M, AU - Betz,Randal R, AU - El-Hawary,Ron, AU - Hwang,Steven W, Y1 - 2016/09/02/ PY - 2016/9/3/pubmed PY - 2017/2/15/medline PY - 2016/9/3/entrez KW - CM-I = Chiari I malformation KW - Chiari I malformation KW - decompression KW - fusion KW - scoliosis KW - spine SP - 737 EP - 743 JF - Journal of neurosurgery. Pediatrics JO - J Neurosurg Pediatr VL - 25 IS - 6 N2 - OBJECTIVE The authors performed a study to identify clinical characteristics of pediatric patients diagnosed with Chiari I malformation and scoliosis associated with a need for spinal fusion after posterior fossa decompression when managing the scoliotic curve. METHODS The authors conducted a multicenter retrospective review of 44 patients, aged 18 years or younger, diagnosed with Chiari I malformation and scoliosis who underwent posterior fossa decompression from 2000 to 2010. The outcome of interest was the need for spinal fusion after decompression. RESULTS Overall, 18 patients (40%) underwent posterior fossa decompression alone, and 26 patients (60%) required a spinal fusion after the decompression. The mean Cobb angle at presentation and the proportion of patients with curves > 35° differed between the decompression-only and fusion cohorts (30.7° ± 11.8° vs 52.1° ± 26.3°, p = 0.002; 5 of 18 vs 17 of 26, p = 0.031). An odds ratio of 1.0625 favoring a need for fusion was established for each 1° of increase in Cobb angle (p = 0.012, OR 1.0625, 95% CI 1.0135-1.1138). Among the 14 patients older than 10 years of age with a primary Cobb angle exceeding 35°, 13 (93%) ultimately required fusion. Patients with at least 1 year of follow-up whose curves progressed more 10° after decompression were younger than those without curve progression (6.1 ± 3.0 years vs 13.7 ± 3.2 years, p = 0.001, Mann-Whitney U-test). Left apical thoracic curves constituted a higher proportion of curves in the decompression-only group (8 of 16 vs 1 of 21, p = 0.002). CONCLUSIONS The need for fusion after posterior fossa decompression reflected the curve severity at clinical presentation. Patients presenting with curves measuring > 35°, as well as those greater than 10 years of age, may be at greater risk for requiring fusion after posterior fossa decompression, while patients less than 10 years of age may require routine monitoring for curve progression. Left apical thoracic curves may have a better response to Chiari malformation decompression. SN - 1933-0715 UR - https://www.unboundmedicine.com/medline/citation/27589598/Factors_associated_with_spinal_fusion_after_posterior_fossa_decompression_in_pediatric_patients_with_Chiari_I_malformation_and_scoliosis_ L2 - https://thejns.org/doi/10.3171/2016.5.PEDS16180 DB - PRIME DP - Unbound Medicine ER -