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Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.).
Lipids. 2016 10; 51(10):1171-1191.L

Abstract

Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) are essential components of the diet of all vertebrates. The major dietary source of n-3 LC-PUFA for humans has been fish and seafood but, paradoxically, farmed fish are also reliant on marine fisheries for fish meal and fish oil (FO), traditionally major ingredients of aquafeeds. Currently, the only sustainable alternatives to FO are vegetable oils, which are rich in C18 PUFA, but devoid of the eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) abundant in FO. Two new n-3 LC-PUFA sources obtained from genetically modified (GM) Camelina sativa containing either EPA alone (ECO) or EPA and DHA (DCO) were compared to FO and wild-type camelina oil (WCO) in juvenile sea bream. Neither ECO nor DCO had any detrimental effects on fish performance, although final weight of ECO-fed fish (117 g) was slightly lower than that of FO- and DCO-fed fish (130 and 127 g, respectively). Inclusion of the GM-derived oils enhanced the n-3 LC-PUFA content in fish tissues compared to WCO, although limited biosynthesis was observed indicating accumulation of dietary fatty acids. The expression of genes involved in several lipid metabolic processes, as well as fish health and immune response, in both liver and anterior intestine were altered in fish fed the GM-derived oils. This showed a similar pattern to that observed in WCO-fed fish reflecting the hybrid fatty acid profile of the new oils. Overall the data indicated that the GM-derived oils could be suitable alternatives to dietary FO in sea bream.

Authors+Show Affiliations

Faculty of Natural Sciences, Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, UK. m.b.betancor@stir.ac.uk.Faculty of Natural Sciences, Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, UK.Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, Universidad de Las Palmas de Gran Canaria, Ctra. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain.Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden, AL5 2JQ, UK.Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden, AL5 2JQ, UK.Biomar Ltd., North Shore Road, Grangemouth, FK3 8UL, UK.Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden, AL5 2JQ, UK.Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, Universidad de Las Palmas de Gran Canaria, Ctra. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain.Grupo de Investigación en Acuicultura (GIA), Instituto Universitario Ecoaqua, Universidad de Las Palmas de Gran Canaria, Ctra. Taliarte s/n, 35214, Telde, Las Palmas, Canary Islands, Spain.Faculty of Natural Sciences, Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, UK.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27590240

Citation

Betancor, Mónica B., et al. "Replacement of Marine Fish Oil With De Novo Omega-3 Oils From Transgenic Camelina Sativa in Feeds for Gilthead Sea Bream (Sparus Aurata L.)." Lipids, vol. 51, no. 10, 2016, pp. 1171-1191.
Betancor MB, Sprague M, Montero D, et al. Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.). Lipids. 2016;51(10):1171-1191.
Betancor, M. B., Sprague, M., Montero, D., Usher, S., Sayanova, O., Campbell, P. J., Napier, J. A., Caballero, M. J., Izquierdo, M., & Tocher, D. R. (2016). Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.). Lipids, 51(10), 1171-1191. https://doi.org/10.1007/s11745-016-4191-4
Betancor MB, et al. Replacement of Marine Fish Oil With De Novo Omega-3 Oils From Transgenic Camelina Sativa in Feeds for Gilthead Sea Bream (Sparus Aurata L.). Lipids. 2016;51(10):1171-1191. PubMed PMID: 27590240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.). AU - Betancor,Mónica B, AU - Sprague,M, AU - Montero,D, AU - Usher,S, AU - Sayanova,O, AU - Campbell,P J, AU - Napier,J A, AU - Caballero,M J, AU - Izquierdo,M, AU - Tocher,D R, Y1 - 2016/09/02/ PY - 2016/07/22/received PY - 2016/08/19/accepted PY - 2016/9/4/entrez PY - 2016/9/4/pubmed PY - 2017/6/14/medline KW - Camelina KW - Genetically modified KW - Sea bream KW - Sustainable feeds SP - 1171 EP - 1191 JF - Lipids JO - Lipids VL - 51 IS - 10 N2 - Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) are essential components of the diet of all vertebrates. The major dietary source of n-3 LC-PUFA for humans has been fish and seafood but, paradoxically, farmed fish are also reliant on marine fisheries for fish meal and fish oil (FO), traditionally major ingredients of aquafeeds. Currently, the only sustainable alternatives to FO are vegetable oils, which are rich in C18 PUFA, but devoid of the eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) abundant in FO. Two new n-3 LC-PUFA sources obtained from genetically modified (GM) Camelina sativa containing either EPA alone (ECO) or EPA and DHA (DCO) were compared to FO and wild-type camelina oil (WCO) in juvenile sea bream. Neither ECO nor DCO had any detrimental effects on fish performance, although final weight of ECO-fed fish (117 g) was slightly lower than that of FO- and DCO-fed fish (130 and 127 g, respectively). Inclusion of the GM-derived oils enhanced the n-3 LC-PUFA content in fish tissues compared to WCO, although limited biosynthesis was observed indicating accumulation of dietary fatty acids. The expression of genes involved in several lipid metabolic processes, as well as fish health and immune response, in both liver and anterior intestine were altered in fish fed the GM-derived oils. This showed a similar pattern to that observed in WCO-fed fish reflecting the hybrid fatty acid profile of the new oils. Overall the data indicated that the GM-derived oils could be suitable alternatives to dietary FO in sea bream. SN - 1558-9307 UR - https://www.unboundmedicine.com/medline/citation/27590240/Replacement_of_Marine_Fish_Oil_with_de_novo_Omega_3_Oils_from_Transgenic_Camelina_sativa_in_Feeds_for_Gilthead_Sea_Bream__Sparus_aurata_L___ L2 - https://link.springer.com/article/10.1007/s11745-016-4191-4 DB - PRIME DP - Unbound Medicine ER -