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Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer's disease.
Neuroradiology. 2016 Nov; 58(11):1143-1151.N

Abstract

INTRODUCTION

This study aimed to examine the relationship between gender, apolipoprotein E (APOE) genotype, and mesial temporal atrophy in mild cognitive impairment (MCI) with and without progression to Alzheimer's disease (AD).

METHODS

We evaluated 236 MCI patients with (n = 121) and without (n = 115) AD progression. Longitudinal MRI-based hippocampal volumes (HV) and entorhinal cortex (ERC) thickness were obtained. The Clinical Dementia Rating Sum of Boxes (CDR-SB) score was used to assess disease severity.

RESULTS

We found a significant effect of APOE, gender, and clinical course (stable MCI versus MCI-AD progression) on HV. There was a significant effect of clinical course and APOE, but not gender, on ERC. Baseline HV and APOE4 status predicted MCI-AD progression in women. Baseline ERC and APOE4 status predicted MCI-AD progression in men. There were significant differences in CDR-SB scores between patients with and without MCI-AD progression, but not between males and females, or APOE4 carriers and non-carriers.

CONCLUSIONS

HV, but not ERC, is strongly influenced by gender in MCI. The effects of gender and APOE4 on neuroimaging biomarkers have potentially important implications in the prediction of MCI-AD progression and should be taken into account in clinical trials.

Authors+Show Affiliations

Spampinato MV
Department of Radiology and Radiological Science, Medical University of South Carolina, 96 Jonathan Lucas Street, MSC 323, Charleston, SC, 29401, USA. spampin@musc.edu.
Langdon BR
Department of Internal Medicine, Medical University of South Carolina, Charleston, SC, USA.
Patrick KE
Department of Radiology and Radiological Science, Medical University of South Carolina, 96 Jonathan Lucas Street, MSC 323, Charleston, SC, 29401, USA.
Parker RO
Department of Anesthesiology, Vanderbilt University, Nashville, TN, USA.
Collins H
Department of Radiology and Radiological Science, Medical University of South Carolina, 96 Jonathan Lucas Street, MSC 323, Charleston, SC, 29401, USA.
Pravata' E
Department of Radiology and Radiological Science, Medical University of South Carolina, 96 Jonathan Lucas Street, MSC 323, Charleston, SC, 29401, USA. Department of Neuroradiology, Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Lugano, Switzerland.
Alzheimer’s Disease Neuroimaging Initiative
No affiliation info available

MeSH

AgedAlzheimer DiseaseApolipoproteins EAtrophyCausalityCognitive DysfunctionComorbidityDisease ProgressionEntorhinal CortexFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHumansIncidenceLongitudinal StudiesMalePolymorphism, Single NucleotideRisk FactorsSex DistributionUnited States

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27590747

Citation

Spampinato, M V., et al. "Gender, Apolipoprotein E Genotype, and Mesial Temporal Atrophy: 2-year Follow-up in Patients With Stable Mild Cognitive Impairment and With Progression From Mild Cognitive Impairment to Alzheimer's Disease." Neuroradiology, vol. 58, no. 11, 2016, pp. 1143-1151.
Spampinato MV, Langdon BR, Patrick KE, et al. Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer's disease. Neuroradiology. 2016;58(11):1143-1151.
Spampinato, M. V., Langdon, B. R., Patrick, K. E., Parker, R. O., Collins, H., & Pravata', E. (2016). Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer's disease. Neuroradiology, 58(11), 1143-1151.
Spampinato MV, et al. Gender, Apolipoprotein E Genotype, and Mesial Temporal Atrophy: 2-year Follow-up in Patients With Stable Mild Cognitive Impairment and With Progression From Mild Cognitive Impairment to Alzheimer's Disease. Neuroradiology. 2016;58(11):1143-1151. PubMed PMID: 27590747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer's disease. AU - Spampinato,M V, AU - Langdon,B R, AU - Patrick,K E, AU - Parker,R O, AU - Collins,H, AU - Pravata',E, AU - ,, Y1 - 2016/09/02/ PY - 2016/05/24/received PY - 2016/08/10/accepted PY - 2016/9/4/pubmed PY - 2018/2/6/medline PY - 2016/9/4/entrez KW - Apolipoprotein E4 KW - Entorhinal cortex KW - Hippocampus KW - MRI KW - Mild cognitive impairment KW - Sex differences SP - 1143 EP - 1151 JF - Neuroradiology JO - Neuroradiology VL - 58 IS - 11 N2 - INTRODUCTION: This study aimed to examine the relationship between gender, apolipoprotein E (APOE) genotype, and mesial temporal atrophy in mild cognitive impairment (MCI) with and without progression to Alzheimer's disease (AD). METHODS: We evaluated 236 MCI patients with (n = 121) and without (n = 115) AD progression. Longitudinal MRI-based hippocampal volumes (HV) and entorhinal cortex (ERC) thickness were obtained. The Clinical Dementia Rating Sum of Boxes (CDR-SB) score was used to assess disease severity. RESULTS: We found a significant effect of APOE, gender, and clinical course (stable MCI versus MCI-AD progression) on HV. There was a significant effect of clinical course and APOE, but not gender, on ERC. Baseline HV and APOE4 status predicted MCI-AD progression in women. Baseline ERC and APOE4 status predicted MCI-AD progression in men. There were significant differences in CDR-SB scores between patients with and without MCI-AD progression, but not between males and females, or APOE4 carriers and non-carriers. CONCLUSIONS: HV, but not ERC, is strongly influenced by gender in MCI. The effects of gender and APOE4 on neuroimaging biomarkers have potentially important implications in the prediction of MCI-AD progression and should be taken into account in clinical trials. SN - 1432-1920 UR - https://www.unboundmedicine.com/medline/citation/27590747/Gender_apolipoprotein_E_genotype_and_mesial_temporal_atrophy:_2_year_follow_up_in_patients_with_stable_mild_cognitive_impairment_and_with_progression_from_mild_cognitive_impairment_to_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -