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Micronutrient intake, from diet and supplements, and association with status markers in pre- and post-RYGB patients.

Abstract

BACKGROUND & AIMS

Roux-en-Y gastric bypass (RYGB) is associated with an increased risk for micronutrient deficiencies. This study aimed to assess total (dietary and supplement) intake and association with iron (including hepcidin), vitamin B12, vitamin C and zinc status markers before and after Roux-en-Y gastric bypass (RYGB).

METHODS

This prospective study included patients with a planned RYGB in University Hospitals Leuven, Belgium; who were followed until 12 months post-RYGB. Patients completed an estimated dietary record of two non-consecutive days before and 1, 3, 6 and 12 months post-RYGB and supplement/drug use was registered. Associations between total micronutrient intake and status markers were analyzed.

RESULTS

Fifty-four patients (21 males; mean age: 48.0 [95%CI 46.6; 49.3] years; mean preoperative BMI: 40.4 [95%CI 39.4; 41.4] kg/m2) were included. One month post-RYGB, usual dietary intake of the studied micronutrients was significantly decreased compared to pre-RYGB, but gradually increased until 12 months post-RYGB, remaining below baseline values. By including micronutrient supplement intake, 12 months post-RYGB values were higher than baseline, except for zinc. Hemoglobin, ferritin, vitamin B12 and C-reactive protein serum concentrations were significantly decreased and transferrin saturation and mean corpuscular volume were significantly increased 12 months post-RYGB. Serum hepcidin concentration was significantly decreased 6 months post-RYGB.

CONCLUSIONS

Medical nutritional therapy is essential following RYGB as dietary intake of iron, vitamin B12, vitamin C, copper and zinc was markedly decreased postoperatively and some patients still had an inadequate total intake one year post-RYGB.

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  • Authors+Show Affiliations

    ,

    KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium; KU Leuven, Clinical and Experimental Endocrinology and University Hospitals Leuven/KU Leuven, Department of Endocrinology, Campus Gasthuisberg, Leuven, Belgium. Electronic address: ina.gesquiere@kuleuven.be.

    ,

    KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.

    ,

    KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.

    ,

    KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.

    ,

    KU Leuven, Clinical and Experimental Endocrinology and University Hospitals Leuven/KU Leuven, Department of Endocrinology, Campus Gasthuisberg, Leuven, Belgium; University Hospitals Leuven/KU Leuven, Department of Abdominal Surgery, Campus Gasthuisberg, Leuven, Belgium.

    ,

    KU Leuven, Clinical and Experimental Endocrinology and University Hospitals Leuven/KU Leuven, Department of Endocrinology, Campus Gasthuisberg, Leuven, Belgium.

    KU Leuven, Clinical and Experimental Endocrinology and University Hospitals Leuven/KU Leuven, Department of Endocrinology, Campus Gasthuisberg, Leuven, Belgium.

    Source

    MeSH

    Belgium
    Biomarkers
    Combined Modality Therapy
    Deficiency Diseases
    Diet Records
    Diet, Reducing
    Dietary Supplements
    Female
    Follow-Up Studies
    Gastric Bypass
    Hospitals, University
    Humans
    Male
    Micronutrients
    Middle Aged
    Nutritional Status
    Obesity, Morbid
    Patient Dropouts
    Postoperative Complications
    Prevalence
    Prospective Studies
    Risk

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    27591033

    Citation

    Gesquiere, Ina, et al. "Micronutrient Intake, From Diet and Supplements, and Association With Status Markers in Pre- and post-RYGB Patients." Clinical Nutrition (Edinburgh, Scotland), vol. 36, no. 4, 2017, pp. 1175-1181.
    Gesquiere I, Foulon V, Augustijns P, et al. Micronutrient intake, from diet and supplements, and association with status markers in pre- and post-RYGB patients. Clin Nutr. 2017;36(4):1175-1181.
    Gesquiere, I., Foulon, V., Augustijns, P., Gils, A., Lannoo, M., Van der Schueren, B., & Matthys, C. (2017). Micronutrient intake, from diet and supplements, and association with status markers in pre- and post-RYGB patients. Clinical Nutrition (Edinburgh, Scotland), 36(4), pp. 1175-1181. doi:10.1016/j.clnu.2016.08.009.
    Gesquiere I, et al. Micronutrient Intake, From Diet and Supplements, and Association With Status Markers in Pre- and post-RYGB Patients. Clin Nutr. 2017;36(4):1175-1181. PubMed PMID: 27591033.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Micronutrient intake, from diet and supplements, and association with status markers in pre- and post-RYGB patients. AU - Gesquiere,Ina, AU - Foulon,Veerle, AU - Augustijns,Patrick, AU - Gils,Ann, AU - Lannoo,Matthias, AU - Van der Schueren,Bart, AU - Matthys,Christophe, Y1 - 2016/08/23/ PY - 2016/03/03/received PY - 2016/08/12/revised PY - 2016/08/16/accepted PY - 2016/9/4/pubmed PY - 2018/3/27/medline PY - 2016/9/4/entrez KW - Bariatric surgery KW - Dietary intake KW - Iron KW - Micronutrient status KW - Roux-en-Y gastric bypass KW - Supplement use SP - 1175 EP - 1181 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 36 IS - 4 N2 - BACKGROUND & AIMS: Roux-en-Y gastric bypass (RYGB) is associated with an increased risk for micronutrient deficiencies. This study aimed to assess total (dietary and supplement) intake and association with iron (including hepcidin), vitamin B12, vitamin C and zinc status markers before and after Roux-en-Y gastric bypass (RYGB). METHODS: This prospective study included patients with a planned RYGB in University Hospitals Leuven, Belgium; who were followed until 12 months post-RYGB. Patients completed an estimated dietary record of two non-consecutive days before and 1, 3, 6 and 12 months post-RYGB and supplement/drug use was registered. Associations between total micronutrient intake and status markers were analyzed. RESULTS: Fifty-four patients (21 males; mean age: 48.0 [95%CI 46.6; 49.3] years; mean preoperative BMI: 40.4 [95%CI 39.4; 41.4] kg/m2) were included. One month post-RYGB, usual dietary intake of the studied micronutrients was significantly decreased compared to pre-RYGB, but gradually increased until 12 months post-RYGB, remaining below baseline values. By including micronutrient supplement intake, 12 months post-RYGB values were higher than baseline, except for zinc. Hemoglobin, ferritin, vitamin B12 and C-reactive protein serum concentrations were significantly decreased and transferrin saturation and mean corpuscular volume were significantly increased 12 months post-RYGB. Serum hepcidin concentration was significantly decreased 6 months post-RYGB. CONCLUSIONS: Medical nutritional therapy is essential following RYGB as dietary intake of iron, vitamin B12, vitamin C, copper and zinc was markedly decreased postoperatively and some patients still had an inadequate total intake one year post-RYGB. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/27591033/Micronutrient_intake_from_diet_and_supplements_and_association_with_status_markers_in_pre__and_post_RYGB_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(16)30206-0 DB - PRIME DP - Unbound Medicine ER -