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Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure.
Clin Med Insights Cardiol. 2016; 10:139-47.CM

Abstract

The arterial baroreflex system can be divided into the neural arc, from pressure input to efferent sympathetic nerve activity (SNA), and the peripheral arc, from SNA to arterial pressure (AP). Plotting the neural and peripheral arcs on a pressure-SNA plane yields a baroreflex equilibrium diagram. We examined the effects of vagotomy on the open-loop static characteristics of the carotid sinus baroreflex in normal control rats (NC, n = 10) and rats with heart failure after myocardial infarction (MI, n = 10). In the NC group, vagotomy shifted the neural arc toward higher SNA and decreased the slope of the peripheral arc. Consequently, the operating-point SNA increased without a significant change in the operating-point AP on the baroreflex equilibrium diagram. These vagotomy-induced effects were not observed in the MI group, suggesting a loss of vagal modulation of the carotid sinus baroreflex function in heart failure.

Authors+Show Affiliations

Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27594790

Citation

Kawada, Toru, et al. "Acute Effects of Vagotomy On Baroreflex Equilibrium Diagram in Rats With Chronic Heart Failure." Clinical Medicine Insights. Cardiology, vol. 10, 2016, pp. 139-47.
Kawada T, Li M, Zheng C, et al. Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure. Clinical Medicine Insights. Cardiology. 2016;10:139-47.
Kawada, T., Li, M., Zheng, C., & Sugimachi, M. (2016). Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure. Clinical Medicine Insights. Cardiology, 10, 139-47. https://doi.org/10.4137/CMC.S38443
Kawada T, et al. Acute Effects of Vagotomy On Baroreflex Equilibrium Diagram in Rats With Chronic Heart Failure. Clinical Medicine Insights. Cardiology. 2016;10:139-47. PubMed PMID: 27594790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure. AU - Kawada,Toru, AU - Li,Meihua, AU - Zheng,Can, AU - Sugimachi,Masaru, Y1 - 2016/08/28/ PY - 2016/05/13/received PY - 2016/08/01/revised PY - 2016/08/05/accepted PY - 2016/9/6/entrez PY - 2016/9/7/pubmed PY - 2016/9/7/medline KW - arterial pressure KW - carotid sinus baroreflex KW - equilibrium diagram KW - myocardial infarction KW - open-loop analysis KW - sympathetic nerve activity SP - 139 EP - 47 JF - Clinical Medicine Insights. Cardiology VL - 10 N2 - The arterial baroreflex system can be divided into the neural arc, from pressure input to efferent sympathetic nerve activity (SNA), and the peripheral arc, from SNA to arterial pressure (AP). Plotting the neural and peripheral arcs on a pressure-SNA plane yields a baroreflex equilibrium diagram. We examined the effects of vagotomy on the open-loop static characteristics of the carotid sinus baroreflex in normal control rats (NC, n = 10) and rats with heart failure after myocardial infarction (MI, n = 10). In the NC group, vagotomy shifted the neural arc toward higher SNA and decreased the slope of the peripheral arc. Consequently, the operating-point SNA increased without a significant change in the operating-point AP on the baroreflex equilibrium diagram. These vagotomy-induced effects were not observed in the MI group, suggesting a loss of vagal modulation of the carotid sinus baroreflex function in heart failure. SN - 1179-5468 UR - https://www.unboundmedicine.com/medline/citation/27594790/Acute_Effects_of_Vagotomy_on_Baroreflex_Equilibrium_Diagram_in_Rats_with_Chronic_Heart_Failure_ L2 - https://journals.sagepub.com/doi/10.4137/CMC.S38443?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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