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The Effect of Age on Dexamethasone Intravitreal Implant (Ozurdex®) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion.
Semin Ophthalmol. 2018; 33(2):179-184.SO

Abstract

PURPOSE

To investigate the effect of age on dexamethasone intravitreal implant (Ozurdex®) response in macular edema secondary to branch retinal vein occlusion (BRVO).

METHODS

Seventy-three eyes of 73 patients with macular edema secondary to BRVO were recruited in the study. The patients in the study were divided into the following four groups according to their ages: group 1 (<60 years), group 2 (60-69 years), group 3 (70-79 years), and group 4 (≥80 years). Single-dose Ozurdex injection was applied to all patients. The effectiveness of Ozurdex treatment on macular edema is evaluated via optical coherence tomography (OCT) according to the age groups.

RESULTS

Two months after Ozurdex injection, mean reduction of central retinal thickness in groups 1, 2, 3, and 4 were -466.4 ± 149.6, -379.7 ± 238.7, -280.1 ± 233.0, and -180.5 ± 81.4 µm, respectively. This reduction of central retinal thickness decreased with aging (p = 0.001). Also, ages of patients were negatively correlated with the mean reduction of central retinal thickness for the whole study group (r = -0.439, p < 0.001).

CONCLUSION

Our study revealed that the effectiveness of Ozurdex treatment decreases with aging.

Authors+Show Affiliations

a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.a Kayseri Education and Research Hospital , Department of Ophthalmology , Kayseri , Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27599562

Citation

Altunel, Orhan, et al. "The Effect of Age On Dexamethasone Intravitreal Implant (Ozurdex®) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion." Seminars in Ophthalmology, vol. 33, no. 2, 2018, pp. 179-184.
Altunel O, Göktaş A, Duru N, et al. The Effect of Age on Dexamethasone Intravitreal Implant (Ozurdex®) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion. Semin Ophthalmol. 2018;33(2):179-184.
Altunel, O., Göktaş, A., Duru, N., Özköse, A., Arifoğlu, H. B., & Ataş, M. (2018). The Effect of Age on Dexamethasone Intravitreal Implant (Ozurdex®) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion. Seminars in Ophthalmology, 33(2), 179-184. https://doi.org/10.1080/08820538.2016.1188128
Altunel O, et al. The Effect of Age On Dexamethasone Intravitreal Implant (Ozurdex®) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion. Semin Ophthalmol. 2018;33(2):179-184. PubMed PMID: 27599562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Age on Dexamethasone Intravitreal Implant (Ozurdex®) Response in Macular Edema Secondary to Branch Retinal Vein Occlusion. AU - Altunel,Orhan, AU - Göktaş,Altan, AU - Duru,Necati, AU - Özköse,Ayşe, AU - Arifoğlu,Hasan Basri, AU - Ataş,Mustafa, Y1 - 2016/09/06/ PY - 2016/9/8/pubmed PY - 2018/4/24/medline PY - 2016/9/8/entrez KW - Age KW - Dexamethasone intravitreal implant KW - Ozurdex KW - branch retinal vein occlusion KW - optical coherence tomography SP - 179 EP - 184 JF - Seminars in ophthalmology JO - Semin Ophthalmol VL - 33 IS - 2 N2 - PURPOSE: To investigate the effect of age on dexamethasone intravitreal implant (Ozurdex®) response in macular edema secondary to branch retinal vein occlusion (BRVO). METHODS: Seventy-three eyes of 73 patients with macular edema secondary to BRVO were recruited in the study. The patients in the study were divided into the following four groups according to their ages: group 1 (<60 years), group 2 (60-69 years), group 3 (70-79 years), and group 4 (≥80 years). Single-dose Ozurdex injection was applied to all patients. The effectiveness of Ozurdex treatment on macular edema is evaluated via optical coherence tomography (OCT) according to the age groups. RESULTS: Two months after Ozurdex injection, mean reduction of central retinal thickness in groups 1, 2, 3, and 4 were -466.4 ± 149.6, -379.7 ± 238.7, -280.1 ± 233.0, and -180.5 ± 81.4 µm, respectively. This reduction of central retinal thickness decreased with aging (p = 0.001). Also, ages of patients were negatively correlated with the mean reduction of central retinal thickness for the whole study group (r = -0.439, p < 0.001). CONCLUSION: Our study revealed that the effectiveness of Ozurdex treatment decreases with aging. SN - 1744-5205 UR - https://www.unboundmedicine.com/medline/citation/27599562/The_Effect_of_Age_on_Dexamethasone_Intravitreal_Implant__Ozurdex®__Response_in_Macular_Edema_Secondary_to_Branch_Retinal_Vein_Occlusion_ L2 - https://www.tandfonline.com/doi/full/10.1080/08820538.2016.1188128 DB - PRIME DP - Unbound Medicine ER -