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Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis.
J Oral Pathol Med. 2017 Apr; 46(4):307-312.JO

Abstract

BACKGROUND

Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV).

METHODS

Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG-) patients, and 100 healthy control subjects.

RESULTS

The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG- patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG- patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG- patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively.

CONCLUSION

We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG- patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.

Authors+Show Affiliations

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27599778

Citation

Chang, Julia Yu-Fong, et al. "Antigastric Parietal Cell and Antithyroid Autoantibodies in Patients With Desquamative Gingivitis." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 46, no. 4, 2017, pp. 307-312.
Chang JY, Chiang CP, Wang YP, et al. Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. J Oral Pathol Med. 2017;46(4):307-312.
Chang, J. Y., Chiang, C. P., Wang, Y. P., Wu, Y. C., Chen, H. M., & Sun, A. (2017). Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 46(4), 307-312. https://doi.org/10.1111/jop.12490
Chang JY, et al. Antigastric Parietal Cell and Antithyroid Autoantibodies in Patients With Desquamative Gingivitis. J Oral Pathol Med. 2017;46(4):307-312. PubMed PMID: 27599778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. AU - Chang,Julia Yu-Fong, AU - Chiang,Chun-Pin, AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Chen,Hsin-Ming, AU - Sun,Andy, Y1 - 2016/09/07/ PY - 2016/08/01/accepted PY - 2016/9/8/pubmed PY - 2018/3/14/medline PY - 2016/9/8/entrez KW - antigastric parietal cell antibody KW - antithyroglobulin antibody KW - antithyroid microsomal antibody KW - desquamative gingivitis KW - erosive oral lichen planus SP - 307 EP - 312 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 46 IS - 4 N2 - BACKGROUND: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). METHODS: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG-) patients, and 100 healthy control subjects. RESULTS: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG- patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG- patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG- patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. CONCLUSION: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG- patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/27599778/Antigastric_parietal_cell_and_antithyroid_autoantibodies_in_patients_with_desquamative_gingivitis_ L2 - https://doi.org/10.1111/jop.12490 DB - PRIME DP - Unbound Medicine ER -