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Camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats.
J Dairy Res. 2016 Aug; 83(3):412-9.JD

Abstract

This study was designed to assess anti-diabetic potential of goat, camel, cow and buffalo milk in streptozotocin (STZ) induced type 1 diabetic albino wistar rats. A total of 48 rats were taken for the study where one group was kept as non-diabetic control group (8 rats) while others (40 rats) were made diabetic by STZ (50 mg/kg of body weight) injection. Among diabetic rats, a control group (8 rats) was kept and referred as diabetic control whereas other four groups (8 rats each) of diabetic rats were fed on 50 ml of goat or camel or cow or buffalo milk for 4 weeks. All the rats (non-diabetic and diabetic) were maintained on standard diet for four weeks. STZ administration resulted in enhancement of glucose, total cholesterol, triglyceride, low density lipoprotein, HbA1c and reduction in high density lipoprotein in plasma and lowering of antioxidative enzymes (catalase, glutathione peroxidase and superoxide dismutase) activities in pancreas, kidney, liver and RBCs, coupled with enhanced levels of TBARS and protein carbonyls in pancreas, kidney, liver and plasma. OGTT carried out at the end of 4 week milk feeding indicated that all milks helped in early maintenance of glucose level. All milks reduced atherogenic index. In camel milk fed diabetic group, insulin concentration enhanced to level noted for non-diabetic control while goat, cow and buffalo milk failed to restore insulin level. HbA1c level was also restored only in camel milk fed diabetic group. The level of antioxidative enzymes (catalase, GPx and SOD) in pancreas enhanced in all milk fed groups. Camel milk and to a reasonable extent goat milk reduced formation of TBARS and PCs in tissues and blood. It can be concluded that camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats. Further, only camel milk completely ameliorated oxidative damage in pancreas and normalised insulin level.

Authors+Show Affiliations

Animal Biochemistry Division,National Dairy Research Institute,Karnal 132001,India.Animal Biochemistry Division,National Dairy Research Institute,Karnal 132001,India.Animal Biochemistry Division,National Dairy Research Institute,Karnal 132001,India.Dairy Chemistry Division,National Dairy Research Institute,Karnal 132001,India.National Research Centre on Camel,Bikaner 334001,India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27600979

Citation

Meena, Sunita, et al. "Camel Milk Ameliorates Hyperglycaemia and Oxidative Damage in Type-1 Diabetic Experimental Rats." The Journal of Dairy Research, vol. 83, no. 3, 2016, pp. 412-9.
Meena S, Rajput YS, Pandey AK, et al. Camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats. J Dairy Res. 2016;83(3):412-9.
Meena, S., Rajput, Y. S., Pandey, A. K., Sharma, R., & Singh, R. (2016). Camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats. The Journal of Dairy Research, 83(3), 412-9. https://doi.org/10.1017/S002202991600042X
Meena S, et al. Camel Milk Ameliorates Hyperglycaemia and Oxidative Damage in Type-1 Diabetic Experimental Rats. J Dairy Res. 2016;83(3):412-9. PubMed PMID: 27600979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats. AU - Meena,Sunita, AU - Rajput,Yudhishthir S, AU - Pandey,Amit K, AU - Sharma,Rajan, AU - Singh,Raghvendar, PY - 2016/9/8/entrez PY - 2016/9/8/pubmed PY - 2017/2/14/medline KW - AI atherogenic index KW - AUC area under curve KW - Camel milk KW - Cu-TEA Cu-triethanolamine KW - FFAs free fatty acids KW - GPx glutathione peroxidase KW - HDL-C high density lipoprotein cholesterol KW - HbA1c glycosylated haemoglobin KW - LDL-C low density lipoprotein cholesterol KW - OGTT oral glucose tolerance test KW - PCs protein carbonyls KW - RBC red blood cell KW - ROS reactive oxygen species KW - SD standard diet KW - SOD superoxide dismutase KW - STZ streptozotocin KW - TBARS thiobarbituric acid reactive substances KW - TC total cholesterol KW - TGs triglycerides KW - VLDL-C very low density lipoprotein cholesterol KW - antioxidant KW - diabetes KW - goat milk SP - 412 EP - 9 JF - The Journal of dairy research JO - J. Dairy Res. VL - 83 IS - 3 N2 - This study was designed to assess anti-diabetic potential of goat, camel, cow and buffalo milk in streptozotocin (STZ) induced type 1 diabetic albino wistar rats. A total of 48 rats were taken for the study where one group was kept as non-diabetic control group (8 rats) while others (40 rats) were made diabetic by STZ (50 mg/kg of body weight) injection. Among diabetic rats, a control group (8 rats) was kept and referred as diabetic control whereas other four groups (8 rats each) of diabetic rats were fed on 50 ml of goat or camel or cow or buffalo milk for 4 weeks. All the rats (non-diabetic and diabetic) were maintained on standard diet for four weeks. STZ administration resulted in enhancement of glucose, total cholesterol, triglyceride, low density lipoprotein, HbA1c and reduction in high density lipoprotein in plasma and lowering of antioxidative enzymes (catalase, glutathione peroxidase and superoxide dismutase) activities in pancreas, kidney, liver and RBCs, coupled with enhanced levels of TBARS and protein carbonyls in pancreas, kidney, liver and plasma. OGTT carried out at the end of 4 week milk feeding indicated that all milks helped in early maintenance of glucose level. All milks reduced atherogenic index. In camel milk fed diabetic group, insulin concentration enhanced to level noted for non-diabetic control while goat, cow and buffalo milk failed to restore insulin level. HbA1c level was also restored only in camel milk fed diabetic group. The level of antioxidative enzymes (catalase, GPx and SOD) in pancreas enhanced in all milk fed groups. Camel milk and to a reasonable extent goat milk reduced formation of TBARS and PCs in tissues and blood. It can be concluded that camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats. Further, only camel milk completely ameliorated oxidative damage in pancreas and normalised insulin level. SN - 1469-7629 UR - https://www.unboundmedicine.com/medline/citation/27600979/Camel_milk_ameliorates_hyperglycaemia_and_oxidative_damage_in_type_1_diabetic_experimental_rats_ L2 - https://www.cambridge.org/core/product/identifier/S002202991600042X/type/journal_article DB - PRIME DP - Unbound Medicine ER -