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Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population.

Abstract

BACKGROUND AND AIM

Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD.

METHODS

Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory.

RESULTS

In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn's disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency.

CONCLUSIONS

Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity.

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  • Authors+Show Affiliations

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    a Department of Research , Østfold Hospital Trust , Grålum , Norway. b Department of Medicine , Bærum Hospital, Vestre Viken Hospital Trust , Drammen , Norway. c Institute of Clinical Medicine , University of Oslo , Norway.

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    c Institute of Clinical Medicine , University of Oslo , Norway. d Department of Gastroenterology , Oslo University Hospital , Oslo , Norway.

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    c Institute of Clinical Medicine , University of Oslo , Norway. e Department of Gastroenterology , Akershus University Hospital , Lørenskog , Norway.

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    f The Hormone Laboratory, Department of Medical Biochemistry , Oslo University Hospital , Oslo , Norway.

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    c Institute of Clinical Medicine , University of Oslo , Norway. g Department of Biostatistics , Oslo and Akershus University College , Oslo , Norway.

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    h Department of Gastroenterology , Stavanger University Hospital , Stavanger , Norway.

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    i Department of Medicine , Ålesund Hospital Trust , Ålesund , Norway.

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    j Department of Research and Development , Telemark Hospital Trust , Skien , Norway.

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    c Institute of Clinical Medicine , University of Oslo , Norway. k Department of Medicine , Innlandet Hospital Trust , Gjøvik , Norway.

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    l Department of Medicine , Innlandet Hospital Trust , Hamar , Norway.

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    c Institute of Clinical Medicine , University of Oslo , Norway. m Department of Gastroenterology , Østfold Hospital Trust , Grålum , Norway.

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    c Institute of Clinical Medicine , University of Oslo , Norway. d Department of Gastroenterology , Oslo University Hospital , Oslo , Norway.

    m Department of Gastroenterology , Østfold Hospital Trust , Grålum , Norway. n Department of Health Sciences , Østfold University College , Fredrikstad , Norway.

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Colitis, Ulcerative
    Crohn Disease
    Disease Progression
    Female
    Humans
    Logistic Models
    Male
    Middle Aged
    Multivariate Analysis
    Norway
    Outpatients
    Risk Factors
    Severity of Illness Index
    Vitamin D
    Vitamin D Deficiency
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Observational Study

    Language

    eng

    PubMed ID

    27603182

    Citation

    Frigstad, Svein Oskar, et al. "Vitamin D Deficiency in Inflammatory Bowel Disease: Prevalence and Predictors in a Norwegian Outpatient Population." Scandinavian Journal of Gastroenterology, vol. 52, no. 1, 2017, pp. 100-106.
    Frigstad SO, Høivik M, Jahnsen J, et al. Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population. Scand J Gastroenterol. 2017;52(1):100-106.
    Frigstad, S. O., Høivik, M., Jahnsen, J., Dahl, S. R., Cvancarova, M., Grimstad, T., ... Jelsness-Jørgensen, L. P. (2017). Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population. Scandinavian Journal of Gastroenterology, 52(1), pp. 100-106. doi:10.1080/00365521.2016.1233577.
    Frigstad SO, et al. Vitamin D Deficiency in Inflammatory Bowel Disease: Prevalence and Predictors in a Norwegian Outpatient Population. Scand J Gastroenterol. 2017;52(1):100-106. PubMed PMID: 27603182.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population. AU - Frigstad,Svein Oskar, AU - Høivik,Marte, AU - Jahnsen,Jørgen, AU - Dahl,Sandra Rinne, AU - Cvancarova,Milada, AU - Grimstad,Tore, AU - Berset,Ingrid Prytz, AU - Huppertz-Hauss,Gert, AU - Hovde,Øistein, AU - Torp,Roald, AU - Bernklev,Tomm, AU - Moum,Bjørn, AU - Jelsness-Jørgensen,Lars-Petter, Y1 - 2016/09/23/ PY - 2016/9/8/pubmed PY - 2017/9/12/medline PY - 2016/9/8/entrez KW - Inflammatory bowel disease KW - epidemiology KW - vitamin D deficiency SP - 100 EP - 106 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 52 IS - 1 N2 - BACKGROUND AND AIM: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD. METHODS: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory. RESULTS: In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn's disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency. CONCLUSIONS: Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/27603182/Vitamin_D_deficiency_in_inflammatory_bowel_disease:_prevalence_and_predictors_in_a_Norwegian_outpatient_population_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365521.2016.1233577 DB - PRIME DP - Unbound Medicine ER -