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Efficacy and safety of oral triclofos as sedative for children undergoing sleep electroencephalogram: An observational study.
J Pediatr Neurosci 2016 Apr-Jun; 11(2):105-8JP

Abstract

OBJECTIVES

Triclofos may be a better sedative in view of better palatability and less gastric irritation as compared to chloral hydrate. This study aimed to assess the efficacy of triclofos (a commonly used sedative in India) as a sedative for sleep electroencephalogram (EEG) study in children.

METHODS

This prospective observational study was carried out in a tertiary care pediatric center. Consecutive children aged 6 months to 5 years referred for sleep EEG evaluation were recruited. Their clinical details were noted in a proforma after an informed consent. After a trial for natural sleep, oral triclofos was administered. Sleep parameters and adverse effects were noted.

RESULTS

One-hundred and sixty children were then enrolled. EEG was successfully recorded in 149 (93.1%) children. Median latency of sleep onset was 30 min and median duration of sleep was 90 min. The adverse effects in the following 24 h were mild and included dizziness, irritability, and vomiting.

CONCLUSIONS

Oral triclofos was found to be an effective sedative for EEG in children with minimal adverse effects.

Authors+Show Affiliations

Department of Neonatal, Pediatric and Adolescent Medicine, Division of Pediatric Neurology, BLK Super Speciality Hospital, New Delhi, India.Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.Department of Pediatrics, Division of Pediatric Neurology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27606015

Citation

Jain, Puneet, et al. "Efficacy and Safety of Oral Triclofos as Sedative for Children Undergoing Sleep Electroencephalogram: an Observational Study." Journal of Pediatric Neurosciences, vol. 11, no. 2, 2016, pp. 105-8.
Jain P, Sharma S, Sharma A, et al. Efficacy and safety of oral triclofos as sedative for children undergoing sleep electroencephalogram: An observational study. J Pediatr Neurosci. 2016;11(2):105-8.
Jain, P., Sharma, S., Sharma, A., Goel, S., Jose, A., & Aneja, S. (2016). Efficacy and safety of oral triclofos as sedative for children undergoing sleep electroencephalogram: An observational study. Journal of Pediatric Neurosciences, 11(2), pp. 105-8. doi:10.4103/1817-1745.187622.
Jain P, et al. Efficacy and Safety of Oral Triclofos as Sedative for Children Undergoing Sleep Electroencephalogram: an Observational Study. J Pediatr Neurosci. 2016;11(2):105-8. PubMed PMID: 27606015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of oral triclofos as sedative for children undergoing sleep electroencephalogram: An observational study. AU - Jain,Puneet, AU - Sharma,Suvasini, AU - Sharma,Ankita, AU - Goel,Shaiphali, AU - Jose,Anjali, AU - Aneja,Satinder, PY - 2016/9/9/entrez PY - 2016/9/9/pubmed PY - 2016/9/9/medline KW - Electroencephalogram KW - epilepsy KW - sedation KW - triclofos SP - 105 EP - 8 JF - Journal of pediatric neurosciences JO - J Pediatr Neurosci VL - 11 IS - 2 N2 - OBJECTIVES: Triclofos may be a better sedative in view of better palatability and less gastric irritation as compared to chloral hydrate. This study aimed to assess the efficacy of triclofos (a commonly used sedative in India) as a sedative for sleep electroencephalogram (EEG) study in children. METHODS: This prospective observational study was carried out in a tertiary care pediatric center. Consecutive children aged 6 months to 5 years referred for sleep EEG evaluation were recruited. Their clinical details were noted in a proforma after an informed consent. After a trial for natural sleep, oral triclofos was administered. Sleep parameters and adverse effects were noted. RESULTS: One-hundred and sixty children were then enrolled. EEG was successfully recorded in 149 (93.1%) children. Median latency of sleep onset was 30 min and median duration of sleep was 90 min. The adverse effects in the following 24 h were mild and included dizziness, irritability, and vomiting. CONCLUSIONS: Oral triclofos was found to be an effective sedative for EEG in children with minimal adverse effects. SN - 1817-1745 UR - https://www.unboundmedicine.com/medline/citation/27606015/Efficacy_and_safety_of_oral_triclofos_as_sedative_for_children_undergoing_sleep_electroencephalogram:_An_observational_study_ L2 - http://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2016;volume=11;issue=2;spage=105;epage=108;aulast=Jain DB - PRIME DP - Unbound Medicine ER -