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Diffuse "encephalitic" cerebral toxoplasmosis in AIDS. Report of four cases.

Abstract

Four patients with AIDS presented with a rapidly fatal global neurological illness. CT did not show any focal lesion and gross post mortem examination of the brain was normal in three of the four cases. Microscopic examination revealed numerous widespread microglial nodules in the brain parenchyma, most containing central toxoplama cysts or free tachyzoites. Such diffuse, non-necrotic, "encephalitic" forms of cerebral toxoplasmosis appear unique to AIDS and, to our knowledge, have not been documented previously. They represent a treatable, often misdiagnosed cause of diffuse neurological involvement in AIDS patients.

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  • Authors+Show Affiliations

    ,

    Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, Créteil, France.

    , , , , , ,

    Source

    Journal of neurology 236:5 1989 Jul pg 273-7

    MeSH

    Acquired Immunodeficiency Syndrome
    Adult
    Aged
    Autopsy
    Brain
    Encephalitis
    Humans
    Male
    Middle Aged
    Opportunistic Infections
    Toxoplasmosis

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    2760644

    Citation

    Gray, F, et al. "Diffuse "encephalitic" Cerebral Toxoplasmosis in AIDS. Report of Four Cases." Journal of Neurology, vol. 236, no. 5, 1989, pp. 273-7.
    Gray F, Gherardi R, Wingate E, et al. Diffuse "encephalitic" cerebral toxoplasmosis in AIDS. Report of four cases. J Neurol. 1989;236(5):273-7.
    Gray, F., Gherardi, R., Wingate, E., Wingate, J., Fénelon, G., Gaston, A., ... Poirier, J. (1989). Diffuse "encephalitic" cerebral toxoplasmosis in AIDS. Report of four cases. Journal of Neurology, 236(5), pp. 273-7.
    Gray F, et al. Diffuse "encephalitic" Cerebral Toxoplasmosis in AIDS. Report of Four Cases. J Neurol. 1989;236(5):273-7. PubMed PMID: 2760644.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diffuse "encephalitic" cerebral toxoplasmosis in AIDS. Report of four cases. AU - Gray,F, AU - Gherardi,R, AU - Wingate,E, AU - Wingate,J, AU - Fénelon,G, AU - Gaston,A, AU - Sobel,A, AU - Poirier,J, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 273 EP - 7 JF - Journal of neurology JO - J. Neurol. VL - 236 IS - 5 N2 - Four patients with AIDS presented with a rapidly fatal global neurological illness. CT did not show any focal lesion and gross post mortem examination of the brain was normal in three of the four cases. Microscopic examination revealed numerous widespread microglial nodules in the brain parenchyma, most containing central toxoplama cysts or free tachyzoites. Such diffuse, non-necrotic, "encephalitic" forms of cerebral toxoplasmosis appear unique to AIDS and, to our knowledge, have not been documented previously. They represent a treatable, often misdiagnosed cause of diffuse neurological involvement in AIDS patients. SN - 0340-5354 UR - https://www.unboundmedicine.com/medline/citation/2760644/Diffuse_ L2 - http://www.diseaseinfosearch.org/result/279 DB - PRIME DP - Unbound Medicine ER -