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Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid.
Pharm Biol. 2016 Oct; 54(10):2282-7.PB

Abstract

Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxidant activities of ISA. Materials and methods Analgesic and anti-inflammatory activities of ISA were evaluated using writhing, hot plate, xylene-induced ear oedema, carrageenan-induced paw oedema and cotton pellets-induced granuloma test, meanwhile the prostaglandin E2 (PGE2) and malondialdehyde (MDA) levels were assessed in the oedema paw tissue. ISA (60, 120 and 240 mg/kg in mice model and 50, 120 and 200 mg/kg in rat model) was administered orally, 30 min before induction of inflammation/pain. Additionally, ISA was administered for 12 d in rats from the day of cotton pellet implantation. The active oxygen species scavenging potencies of ISA (10(-3)-10(-5) M) were evaluated by the electron spin resonance spin-trapping technique. Results ISA caused a reduction of inflammation induced by xylene (18.1-31.4%), carrageenan (7.8-51.0%) and cotton pellets (11.4-24.0%). Furthermore, ISA decreased the production of PGE2 and MDA in the rat paw tissue by 1.0-15.6% and 6.3-27.6%, respectively. ISA also reduced pain induced by acetic acid (15.6-48.9%) and hot plate (10.5-28.5%). Finally, ISA exhibited moderate antioxidant activity by scavenging the superoxide radical and hydroxyl radical with IC50 values of 0.214 and 0.450 μg/mL, respectively. Discussion and conclusion Our findings confirmed the anti-inflammatory, analgesic and antioxidant activities of ISA.

Authors+Show Affiliations

a School of Pharmacy , Xi'an Jiaotong University , Xi'an , China ; b Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.b Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.a School of Pharmacy , Xi'an Jiaotong University , Xi'an , China ;b Department of Pharmacy , The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.a School of Pharmacy , Xi'an Jiaotong University , Xi'an , China ;

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27609150

Citation

Sun, Jin-Yao, et al. "Anti-inflammatory, Analgesic and Antioxidant Activities of 3,4-oxo-isopropylidene-shikimic Acid." Pharmaceutical Biology, vol. 54, no. 10, 2016, pp. 2282-7.
Sun JY, You CY, Dong K, et al. Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. Pharm Biol. 2016;54(10):2282-7.
Sun, J. Y., You, C. Y., Dong, K., You, H. S., & Xing, J. F. (2016). Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. Pharmaceutical Biology, 54(10), 2282-7. https://doi.org/10.3109/13880209.2016.1153663
Sun JY, et al. Anti-inflammatory, Analgesic and Antioxidant Activities of 3,4-oxo-isopropylidene-shikimic Acid. Pharm Biol. 2016;54(10):2282-7. PubMed PMID: 27609150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid. AU - Sun,Jin-Yao, AU - You,Cui-Yu, AU - Dong,Kai, AU - You,Hai-Sheng, AU - Xing,Jian-Feng, Y1 - 2016/03/24/ PY - 2016/9/10/entrez PY - 2016/9/10/pubmed PY - 2017/2/9/medline KW - Carrageenan KW - Illicium verum Hook.f. KW - malondialdehyde KW - prostaglandin E2 KW - xylene SP - 2282 EP - 7 JF - Pharmaceutical biology JO - Pharm Biol VL - 54 IS - 10 N2 - Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxidant activities of ISA. Materials and methods Analgesic and anti-inflammatory activities of ISA were evaluated using writhing, hot plate, xylene-induced ear oedema, carrageenan-induced paw oedema and cotton pellets-induced granuloma test, meanwhile the prostaglandin E2 (PGE2) and malondialdehyde (MDA) levels were assessed in the oedema paw tissue. ISA (60, 120 and 240 mg/kg in mice model and 50, 120 and 200 mg/kg in rat model) was administered orally, 30 min before induction of inflammation/pain. Additionally, ISA was administered for 12 d in rats from the day of cotton pellet implantation. The active oxygen species scavenging potencies of ISA (10(-3)-10(-5) M) were evaluated by the electron spin resonance spin-trapping technique. Results ISA caused a reduction of inflammation induced by xylene (18.1-31.4%), carrageenan (7.8-51.0%) and cotton pellets (11.4-24.0%). Furthermore, ISA decreased the production of PGE2 and MDA in the rat paw tissue by 1.0-15.6% and 6.3-27.6%, respectively. ISA also reduced pain induced by acetic acid (15.6-48.9%) and hot plate (10.5-28.5%). Finally, ISA exhibited moderate antioxidant activity by scavenging the superoxide radical and hydroxyl radical with IC50 values of 0.214 and 0.450 μg/mL, respectively. Discussion and conclusion Our findings confirmed the anti-inflammatory, analgesic and antioxidant activities of ISA. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/27609150/Anti_inflammatory_analgesic_and_antioxidant_activities_of_34_oxo_isopropylidene_shikimic_acid_ DB - PRIME DP - Unbound Medicine ER -